Search Results - "Vogelstein, B."

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer by Lee, B., Lipton, L., Cohen, J., Tie, J., Javed, A.A., Li, L., Goldstein, D., Burge, M., Cooray, P., Nagrial, A., Tebbutt, N.C., Thomson, B., Nikfarjam, M., Harris, M., Haydon, A., Lawrence, B., Tai, D.W.M., Simons, K., Lennon, A.M., Wolfgang, C.L., Tomasetti, C., Papadopoulos, N., Kinzler, K.W., Vogelstein, B., Gibbs, P.

“…In early-stage pancreatic cancer, there are currently no biomarkers to guide selection of therapeutic options. This prospective biomarker trial evaluated the…”
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Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer by Tie, J., Kinde, I., Wang, Y., Wong, H.L., Roebert, J., Christie, M., Tacey, M., Wong, R., Singh, M., Karapetis, C.S., Desai, J., Tran, B., Strausberg, R.L., Diaz, L.A., Papadopoulos, N., Kinzler, K.W., Vogelstein, B., Gibbs, P.

“…Early indicators of treatment response in metastatic colorectal cancer (mCRC) could conceivably be used to optimize treatment. We explored early changes in…”
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Cancer genes and the pathways they control by Vogelstein, Bert, Kinzler, Kenneth W

“…The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes…”
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Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation by Park, S., Chu, L.C., Fishman, E.K., Yuille, A.L., Vogelstein, B., Kinzler, K.W., Horton, K.M., Hruban, R.H., Zinreich, E.S., Fadaei Fouladi, D., Shayesteh, S., Graves, J., Kawamoto, S.

“…The purpose of this study was to report procedures developed to annotate abdominal computed tomography (CT) images from subjects without pancreatic disease…”
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Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis by Weisberg, E.M., Chu, L.C., Park, S., Yuille, A.L., Kinzler, K.W., Vogelstein, B., Fishman, E.K.

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Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features by Park, S., Chu, L.C., Hruban, R.H., Vogelstein, B., Kinzler, K.W., Yuille, A.L., Fouladi, D.F., Shayesteh, S., Ghandili, S., Wolfgang, C.L., Burkhart, R., He, J., Fishman, E.K., Kawamoto, S.

“…•CT radiomics differentiates AIP from PDAC with 89.7% sensitivity and 100% specificity.•Thin slice CT radiomics better differentiates AIP from PDAC than thick…”
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Genetic instability in colorectal cancers by Lengauer, C, Kinzler, K. W, Vogelstein, B

“…It has long been considered that genetic instability is an integral component of human neoplasia. In a small fraction of tumours, mismatch repair deficiency…”
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Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics by Lagerstedt Robinson, Kristina, Liu, Tao, Vandrovcova, Jana, Halvarsson, Britta, Clendenning, Mark, Frebourg, Thierry, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Peltomäki, Päivi, Kolodner, Richard D., Nilbert, Mef, Lindblom, Annika

“…Background Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is…”
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Role of BAX in the Apoptotic Response to Anticancer Agents by Zhang, Lin, Yu, Jian, Park, Ben Ho, Kinzler, Kenneth W., Vogelstein, Bert

“…To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were…”
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Requirement for p53 and p21 to sustain G2 arrest after DNA damage by BUNZ, F, DUTRIAUX, A, LENGAUER, C, WALDMAN, T, ZHOU, S, BROWN, J. P, SEDIVY, J. M, KINZLER, K. W, VOGELSTEIN, B

“…After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell cycle. It is shown here that this arrest could be sustained only…”
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A Phosphatase Associated with Metastasis of Colorectal Cancer by Saha, Saurabh, Bardelli, Alberto, Buckhaults, Phillip, Velculescu, Victor E., Rago, Carlo, St. Croix, Brad, Romans, Katharine E., Choti, Michael A., Lengauer, Christoph, Kinzler, Kenneth W., Vogelstein, Bert

“…To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary…”
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Detection of tumor-derived DNA with combination Pap smear and plasma testing in women with primary ovarian cancer: A potential screening test on the horizon? by Nickles Fader, A, Wang, Y, Papadapoulos, N, Stone, R.L, Wang, T.L, Tanner, E.J, Shih, I.M, Vogelstein, B

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Genes Expressed in Human Tumor Endothelium by St. Croix, Brad, Rago, Carlo, Velculescu, Victor, Traverso, Giovanni, Romans, Katharine E., Montgomery, Elizabeth, Lal, Anita, Riggins, Gregory J., Lengauer, Christoph, Vogelstein, Bert, Kinzler, Kenneth W.

“…To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and…”
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Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis by SHIH, Ie-Ming, WEI ZHOU, GOODMAN, Steven N, LENGAUER, Christoph, KINZLER, Kenneth W, VOGELSTEIN, Bert

“…Chromosomal instability is believed to be a common feature of most human tumors, but the stage at which such instability originates has not been defined. At…”
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Identification of c-MYC as a Target of the APC Pathway by He, Tong-Chuan, Sparks, Andrew B., Rago, Carlo, Hermeking, Heiko, Zawel, Leigh, da Costa, Luis T., Morin, Patrice J., Vogelstein, Bert, Kinzler, Kenneth W.

“…The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant…”
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Serial Analysis of Gene Expression by Velculescu, Victor E., Zhang, Lin, Vogelstein, Bert, Kinzler, Kenneth W.

“…The characteristics of an organism are determined by the genes expressed within it. A method was developed, called serial analysis of gene expression (SAGE),…”
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Erratum to “Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation” [Diagn. Interv. Imaging. 101 (2020) 35–44] by Park, S., Chu, L.C., Fishman, E.K., Yuille, A.L., Vogelstein, B., Kinzler, K.W., Horton, K.M., Hruban, R.H., Zinreich, E.S., Fouladi, D.F., Shayesteh, S., Graves, J., Kawamoto, S.

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2777 Lavage of the uterine cavity for early and differential diagnosis of serous ovarian cancer by Maritschnegg, E, Wang, Y, Pecha, N.M, Horvat, R, Van Nieuwenhuysen, E, Vergote, I, Kinde, I, Papadopoulos, N, Diaz, L.A, Kinzler, K.W, Vogelstein, B, Zeillinger, R, Speiser, P

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Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets by Dong, Seung Myung, Traverso, Giovanni, Johnson, Constance, Geng, Li, Favis, Reyna, Boynton, Kevin, Hibi, Kenji, Goodman, Steven N., D'Allessio, Matthew, Paty, Philip, Hamilton, Stanley R., Sidransky, David, Barany, Francis, Levin, Bernard, Shuber, Anthony, Kinzler, Kenneth W., Vogelstein, Bert, Jen, Jin

“…Background: Colorectal cancer cells are shed into the stool, providing a potential means for the early detection of the disease using noninvasive approaches…”
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Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects by Gabelli, Sandra B., Echeverria, Ignacia, Alexander, Megan, Duong-Ly, Krisna C., Chaves-Moreira, Daniele, Brower, Evan T., Vogelstein, B., Amzel, L. Mario

“…PI3Kα, a heterodimeric lipid kinase, catalyzes the conversion of phosphoinositide-4,5-bisphosphate (PIP 2 ) to phosphoinositide-3,4,5-trisphosphate (PIP 3 ), a…”
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