Medial temporal lobe atrophy relates more strongly to sleep-wake rhythm fragmentation than to age or any other known risk

[Display omitted] •Sleep-wake rhythm fragmentation and medial temporal lobe atrophy increase with age.•Sleep-wake rhythm fragmentation and medial temporal lobe atrophy are related.•People with pronounced sleep-wake rhythm fragmentation show more atrophy.•Rhythm fragmentation accounts for individual...

Full description

Saved in:

Bibliographic Details
Published in:	Neurobiology of learning and memory Vol. 160; pp. 132 - 138
Main Authors:	Van Someren, Eus J.W., Oosterman, J.M., Van Harten, B., Vogels, R.L., Gouw, A.A., Weinstein, H.C., Poggesi, A., Scheltens, Ph, Scherder, E.J.A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-04-2019
Subjects:	Actigraphy Aged Aging Aging - pathology Aging - physiology Atrophy - diagnostic imaging Atrophy - pathology Chronobiology Disorders - pathology Chronobiology Disorders - physiopathology Circadian rhythm Female Humans Individuality Magnetic Resonance Imaging Male Medial temporal lobe atrophy Middle Aged Neurodegeneration Physical activity Rhythm fragmentation Sleep Sleep Deprivation - pathology Sleep Deprivation - physiopathology Temporal Lobe - diagnostic imaging Temporal Lobe - pathology AMP MTL Physical activity L5 IS Circadian rhythm GRIN2B IV M10 NR2B Sleep Medial temporal lobe atrophy Neurodegeneration Rhythm fragmentation NMDA Aging MTA SCN
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •Sleep-wake rhythm fragmentation and medial temporal lobe atrophy increase with age.•Sleep-wake rhythm fragmentation and medial temporal lobe atrophy are related.•People with pronounced sleep-wake rhythm fragmentation show more atrophy.•Rhythm fragmentation accounts for individual differences in atrophy more than age does.•Rhythm fragmentation may accelerate neurodegeneration. Atrophy of the medial temporal lobe of the brain is key to memory function and memory complaints in old age. While age and some morbidities are major risk factors for medial temporal lobe atrophy, individual differences remain, and mechanisms are insufficiently known. The largest combined neuroimaging and whole genome study to date indicates that medial temporal lobe volume is most associated with common polymorphisms in the GRIN2B gene that encodes for the 2B subunit (NR2B) of the NMDA receptor. Because sleep disruption induces a selective loss of NR2B from hippocampal synaptic membranes in rodents, and because of several other reports on medial temporal lobe sensitivity to sleep disruption, we hypothesized a contribution of the typical age-related increase in sleep-wake rhythm fragmentation to medial temporal lobe atrophy. Magnetic resonance imaging and actigraphy in 138 aged individuals showed that individual differences in sleep-wake rhythm fragmentation accounted for more (19%) of the variance in medial temporal lobe atrophy than age did (15%), or any of a list of health and brain structural indicators. The findings suggest a role of sleep-wake rhythm fragmentation in age-related medial temporal lobe atrophy, that might in part be prevented or reversible.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1074-7427 1095-9564
DOI:	10.1016/j.nlm.2018.05.017