Search Results - "Vogel, Constantin"

Conservation analysis of class-specific positions in cytochrome P450 monooxygenases: Functional and structural relevance by Gricman, Łukasz, Vogel, Constantin, Pleiss, Jürgen

“…ABSTRACT Cytochrome P450 monooxygenases (CYPs) constitute a ubiquitous, highly divergent protein family. Nevertheless, all CYPs share a common fold and…”
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A standard numbering scheme for thiamine diphosphate-dependent decarboxylases by Vogel, Constantin, Widmann, Michael, Pohl, Martina, Pleiss, Jürgen

“…Standard numbering schemes for families of homologous proteins allow for the unambiguous identification of functionally and structurally relevant residues, to…”
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The modular structure of ThDP-dependent enzymes by Vogel, Constantin, Pleiss, Jürgen

“…ABSTRACT Thiamine diphosphate (ThDP)‐dependent enzymes form a diverse protein family which was classified into nine superfamilies. The cofactor ThDP is bound…”
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Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining by Gricman, Łukasz, Vogel, Constantin, Pleiss, Jürgen

“…ABSTRACT Cytochrome P450 monooxygenases (CYPs) are a large, highly diverse protein family with a common fold. The sequences, structures, and functions of CYPs…”
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Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases by Zeil, Catharina, Widmann, Michael, Fademrecht, Silvia, Vogel, Constantin, Pleiss, Jürgen

“…The Lactamase Engineering Database (www.LacED.uni-stuttgart.de) was developed to facilitate the classification and analysis of TEM β-lactamases. The current…”
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Engineering stereoselectivity of ThDP‐dependent enzymes by Hailes, Helen C., Rother, Dörte, Müller, Michael, Westphal, Robert, Ward, John M., Pleiss, Jürgen, Vogel, Constantin, Pohl, Martina

“…Thiamine diphosphate‐dependent enzymes are broadly distributed in all organisms, and they catalyse a broad range of C–C bond forming and breaking reactions…”
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A Tailor-Made Chimeric Thiamine Diphosphate Dependent Enzyme for the Direct Asymmetric Synthesis of (S)-Benzoins by Westphal, Robert, Vogel, Constantin, Schmitz, Carlo, Pleiss, Jürgen, Müller, Michael, Pohl, Martina, Rother, Dörte

“…Thiamine diphosphate dependent enzymes are well known for catalyzing the asymmetric synthesis of chiral α‐hydroxy ketones from simple prochiral substrates. The…”
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BioCatNet: A Database System for the Integration of Enzyme Sequences and Biocatalytic Experiments by Buchholz, Patrick C. F., Vogel, Constantin, Reusch, Waldemar, Pohl, Martina, Rother, Dörte, Spieß, Antje C., Pleiss, Jürgen

“…The development of novel enzymes for biocatalytic processes requires knowledge on substrate profile and selectivity; this can be derived from databases and…”
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MenD from Bacillus subtilis: A Potent Catalyst for the Enantiocomplementary Asymmetric Synthesis of Functionalized α-Hydroxy Ketones by Westphal, Robert, Jansen, Sascha, Vogel, Constantin, Pleiss, Jürgen, Müller, Michael, Rother, Dörte, Pohl, Martina

“…The thiamine diphosphate‐dependent enzyme 2‐succinyl‐5‐enolpyruvyl‐6‐hydroxy‐3‐cyclohexene‐1‐carboxylate synthase (MenD) catalyzes a Stetter‐like 1,4‐addition…”
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Corrigendum: A Tailor-Made Chimeric Thiamine Diphosphate Dependent Enzyme for the Direct Asymmetric Synthesis of (S)-Benzoins by Westphal, Robert, Vogel, Constantin, Schmitz, Carlo, Pleiss, Jürgen, Müller, Michael, Pohl, Martina, Rother, Dörte

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MenD from Bacillus subtilis: A Potent Catalyst for the Enantiocomplementary Asymmetric Synthesis of Functionalized [alpha]-Hydroxy Ketones by Westphal, Robert, Jansen, Sascha, Vogel, Constantin, Pleiss, Jurgen, Muller, Michael, Rother, Dörte, Pohl, Martina

“…The thiamine diphosphate-dependent enzyme 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (MenD) catalyzes a Stetter-like 1,4-addition…”
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Tailoring the S-Selectivity of 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate Synthase (MenD) from Escherichia coli by Westphal, Robert, Hahn, Doris, Mackfeld, Ursula, Waltzer, Simon, Beigi, Maryam, Widmann, Michael, Vogel, Constantin, Pleiss, Jürgen, Müller, Michael, Rother, Dörte, Pohl, Martina

“…The thiamine diphosphate (ThDP)‐dependent enzyme 2‐succinyl‐5‐enolpyruvyl‐6‐hydroxy‐3‐cyclohexene‐1‐carboxylate synthase from Escherichia coli (EcMenD, E.C…”
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Cover Picture: Tailoring the S-Selectivity of 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate Synthase (MenD) from Escherichia coli (ChemCatChem 12/2013) by Westphal, Robert, Hahn, Doris, Mackfeld, Ursula, Waltzer, Simon, Beigi, Maryam, Widmann, Michael, Vogel, Constantin, Pleiss, Jürgen, Müller, Michael, Rother, Dörte, Pohl, Martina

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Berichtigung: Ein maßgeschneidertes chimäres Thiamindiphosphat‐abhängiges Enzym zur direkten asymmetrischen Synthese von (S)‐Benzoinen by Westphal, Robert, Vogel, Constantin, Schmitz, Carlo, Pleiss, Jürgen, Müller, Michael, Pohl, Martina, Rother, Dörte

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Ein maßgeschneidertes chimäres Thiamindiphosphat‐abhängiges Enzym zur direkten asymmetrischen Synthese von (S)‐Benzoinen by Westphal, Robert, Vogel, Constantin, Schmitz, Carlo, Pleiss, Jürgen, Müller, Michael, Pohl, Martina, Rother, Dörte

“…Thiamindiphosphat‐abhängige Enzyme sind bekannt für die Katalyse der asymmetrischen Synthese von chiralen α‐Hydroxyketonen ausgehend von einfachen prochiralen…”
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Berichtigung: Ein maßgeschneidertes chimäres Thiamindiphosphat-abhängiges Enzym zur direkten asymmetrischen Synthese von (S)-Benzoinen by Westphal, Robert, Vogel, Constantin, Schmitz, Carlo, Pleiss, Jürgen, Müller, Michael, Pohl, Martina, Rother, Dörte

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Ein maßgeschneidertes chimäres Thiamindiphosphat-abhängiges Enzym zur direkten asymmetrischen Synthese von (S)-Benzoinen by Westphal, Robert, Vogel, Constantin, Schmitz, Carlo, Pleiss, Jürgen, Müller, Michael, Pohl, Martina, Rother, Dörte

“…Abstract Thiamindiphosphat‐abhängige Enzyme sind bekannt für die Katalyse der asymmetrischen Synthese von chiralen α‐Hydroxyketonen ausgehend von einfachen…”
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