A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in Rousettus aegyptiacus Fruit Bats at Multiple Locations in Uganda

A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in Rousettus aegyptiacus Fruit Bats at Multiple Locations in Uganda

In August 2012, a wildlife biologist became ill immediately following a 6-wk field trip to collect bats and rodents in South Sudan and Uganda. After returning to the US, the biologist was admitted to the hospital with multiple symptoms including fever, malaise, headache, generalized myalgia and arth...

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Bibliographic Details
Published in:Journal of wildlife diseases Vol. 51; no. 3; pp. 774 - 779
Main Authors: Amman, Brian R., Albariño, Cesar G., Bird, Brian H., Nyakarahuka, Luke, Sealy, Tara K., Balinandi, Stephen, Schuh, Amy J., Campbell, Shelly M., Ströher, Ute, Jones, Megan E. B., Vodzack, Megan E., Reeder, DeeAnn M., Kaboyo, Winyi, Nichol, Stuart T., Towner, Jonathan S.
Format: Journal Article
Language:English
Published: Business Office, 810 East 10th St., Lawrence, Kansas 66044-8897, USA Wildife Disease Association 01-07-2015
Subjects:
Animals
Animals, Wild - virology
Bats
Chiroptera - virology
Ebolavirus
Female
Humans
Male
Marburgvirus
Paramyxoviridae - physiology
Paramyxoviridae Infections - epidemiology
Paramyxoviridae Infections - veterinary
Paramyxovirus
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction - veterinary
Rousettus aegyptiacus
SHORT COMMUNICATIONS
Sosuga virus
spillover
Uganda - epidemiology
wildlife biologist
United States
Uganda
Sudan
wildlife biologist
Bats
spillover
Sosuga virus
Rousettus aegyptiacus
paramyxovirus
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Summary:In August 2012, a wildlife biologist became ill immediately following a 6-wk field trip to collect bats and rodents in South Sudan and Uganda. After returning to the US, the biologist was admitted to the hospital with multiple symptoms including fever, malaise, headache, generalized myalgia and arthralgia, stiffness in the neck, and sore throat. Soon after admission, the patient developed a maculopapular rash and oropharynx ulcerations. The patient remained hospitalized for 14 d. Several suspect pathogens, including viral hemorrhagic fever viruses such as Ebola viruses and Marburg viruses, were ruled out through standard diagnostic testing. However, deep sequencing and metagenomic analyses identified a novel paramyxovirus, later named Sosuga virus, in the patient's blood. To determine the potential source, bat tissues collected during the 3-wk period just prior to the onset of symptoms were tested for Sosuga virus, and several Egyptian rousette bats (Rousettus aegyptiacus) were found to be positive. Further analysis of archived Egyptian rousette tissues collected at other localities in Uganda found additional Sosuga virus–positive bats, suggesting this species could be a potential natural reservoir for this novel paramyxovirus.
Bibliography:http://dx.doi.org/10.7589%2F2015-02-044
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Current address: San Diego Zoo Institute for Conservation Research, 15600 San Pasqual Valley Road, Escondido, California 92027, USA
Current address: School of Public Health, Johns Hopkins University, 3400 N Charles Street, Baltimore, Maryland 21218, USA
ISSN:0090-3558
1943-3700
DOI:10.7589/2015-02-044