Concept of the noncoenzymatic thiamine effect

Concept of the noncoenzymatic thiamine effect

The experimental and clinical data on different aspects of vitamin and hormone relationships have been summarized in the form of a general concept of the noncoenzymatic thiamine effect, on the basis of a number of premises: (1) discovery of tissue factors limiting the manifestation of the specific a...

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Bibliographic Details
Published in:Medical hypotheses Vol. 49; no. 6; pp. 487 - 495
Main Authors: Vinogradov, V.V., Vodoyevich, V.P., Rozhko, A.V., Vinogradov, S.V.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01-12-1997
Elsevier
Subjects:
Animals
Apoenzymes - metabolism
Biological and medical sciences
Coenzymes
General and cellular metabolism. Vitamins
Hormones - physiology
Humans
Insulin - biosynthesis
Insulin - pharmacology
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Medical sciences
Models, Biological
Pharmacology. Drug treatments
Thiamine - pharmacology
Thiamine - physiology
Thiamine - therapeutic use
Vitamins - physiology
Human
Pancreatic hormone
Endocrine gland
Vitamin
Tissue factor
Homeostasis
Metabolism
Insulin
Biological activity
Protein hormone
Treatment
Hormonal regulation
Thiamine
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Summary:The experimental and clinical data on different aspects of vitamin and hormone relationships have been summarized in the form of a general concept of the noncoenzymatic thiamine effect, on the basis of a number of premises: (1) discovery of tissue factors limiting the manifestation of the specific activity of administered thiamine (the presence of a tissue buffer depot of easily accessible coenzymes, and lack of free apoenzymes); (2) evidence of a thiamine effect on the pancreatic insulin-synthesizing function; (3) stimulation of metabolic thiamine effects, including the effects of insulin administration on thiamine-dependent enzymes; (4) determination of the features of hormonal control of thiamine metabolism in the body; (5) confirmation of the predictive force of the concept by clinical trials of the new strategy of thiamine therapy.
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SourceType-Scholarly Journals-1
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ISSN:0306-9877
1532-2777
DOI:10.1016/S0306-9877(97)90066-9