Search Results - "Völker, Jens"

G‑Quadruplex Recognition by Tetraalkylammonium Ions: A New Paradigm for Discrimination between Parallel and Antiparallel G‑Quadruplexes by Li, Xuan, Dubins, David N., Völker, Jens, Chalikian, Tigran V.

“…G-quadruplexes are an important class of noncanonical secondary structures of DNA that exist in the cell and are involved in the regulation of principal…”
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Heat Capacity Changes (ΔC p ) for Interconversions between Differentially-Ordered DNA States within Physiological Temperature Domains: Implications for Biological Regulatory Switches by Völker, Jens, Plum, G. Eric, Breslauer, Kenneth J

“…Knowledge of differences in heat capacity changes (ΔC p ) between biopolymer states provides essential information about the temperature dependence of the…”
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How sequence alterations enhance the stability and delay expansion of DNA triplet repeat domains by Völker, Jens, Breslauer, Kenneth J.

“…Abstract DNA sequence alterations within DNA repeat domains inexplicably enhance the stability and delay the expansion of interrupted repeat domains. Here we…”
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Dynamic DNA Energy Landscapes and Substrate Complexity in Triplet Repeat Expansion and DNA Repair by Völker, Jens, Plum, G Eric, Gindikin, Vera, Breslauer, Kenneth J

“…DNA repeat domains implicated in DNA expansion diseases exhibit complex conformational and energy landscapes that impact biological outcomes. These landscapes…”
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Optimizing a superconducting radio-frequency gun using deep reinforcement learning by Meier, David, Ramirez, Luis Vera, Völker, Jens, Viefhaus, Jens, Sick, Bernhard, Hartmann, Gregor

“…Superconducting photoelectron injectors are promising for generating highly brilliant pulsed electron beams with high repetition rates and low emittances…”
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Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion by Völker, Jens, Plum, G. Eric, Gindikin, Vera, Klump, Horst H., Breslauer, Kenneth J.

“…ABSTRACT Repetitive DNA sequences exhibit complex structural and energy landscapes, populated by metastable, noncanonical states, that favor expansion and…”
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DNA Repair and DNA Triplet Repeat Expansion: The Impact of Abasic Lesions on Triplet Repeat DNA Energetics by Völker, Jens, Plum, G. Eric, Klump, Horst H, Breslauer, Kenneth J

“…Enhanced levels of DNA triplet expansion are observed when base excision repair (BER) of oxidative DNA base damage (e.g., 8-oxo-dG) occurs at or near CAG…”
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Energy Landscapes of Dynamic Ensembles of Rolling Triplet Repeat Bulge Loops: Implications for DNA Expansion Associated with Disease States by Völker, Jens, Gindikin, Vera, Klump, Horst H., Plum, G. Eric, Breslauer, Kenneth J.

“…DNA repeat domains can form ensembles of canonical and noncanonical states, including stable and metastable DNA secondary structures. Such sequence-induced…”
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A More Unified Picture for the Thermodynamics of Nucleic Acid Duplex Melting: A Characterization by Calorimetric and Volumetric Techniques by Chalikian, Tigran V., Völker, Jens, Plum, G. Eric, Breslauer, Kenneth J.

“…We use a combination of calorimetric and volumetric techniques to detect and to characterize the thermodynamic changes that accompany helix-to-coil transitions…”
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Universal constant for heat production in protists by Johnson, Matthew D, Völker, Jens, Moeller, Holly V, Laws, Edward, Breslauer, Kenneth J, Falkowski, Paul G

“…Using a high sensitivity differential scanning calorimeter in isothermal mode, we directly measured heat production in eukaryotic protists from 5 phyla…”
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The energetics of i-DNA tetraplex structures formed intermolecularly by d(TC5) and intramolecularly by d[(C5T3)3C5] by Völker, Jens, Klump, Horst H., Breslauer, Kenneth J.

“…Cytosine‐rich DNA at low pH adopts an antiparallel tetraplex structure via the intercalation of two partially protonated, parallel stranded duplexes. This…”
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Energy Crosstalk between DNA Lesions: Implications for Allosteric Coupling of DNA Repair and Triplet Repeat Expansion Pathways by Völker, Jens, Plum, G. Eric, Klump, Horst H, Breslauer, Kenneth J

“…Energy coupling between distal DNA domains may have profound regulatory consequences for biological processes, allowing for allosteric control of nucleic acid…”
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DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases by Völker, Jens, Klump, Horst H, Breslauer, Kenneth J

“…Biopolymers exhibit rough energy landscapes, thereby allowing biological processes to access a broad range of kinetic and thermodynamic states. In contrast to…”
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DNA Metastability and Biological Regulation:  Conformational Dynamics of Metastable Ω-DNA Bulge Loops by Völker, Jens, Klump, Horst H, Breslauer, Kenneth J

“…Dynamic interchange between DNA conformations, including metastable states, can be of importance to biological function. In this study, we use a combination of…”
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Structure and Dynamics in DNA Looped Domains:  CAG Triplet Repeat Sequence Dynamics Probed by 2-Aminopurine Fluorescence by Lee, Benjamin J, Barch, Maryan, Castner, Edward W, Völker, Jens, Breslauer, Kenneth J

“…The triplet repeat sequence (CAG) n and related triplet repeats are associated with dynamic DNA mutations implicated in a number of debilitating human…”
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Uranium from German Nuclear Power Projects of the 1940s- A Nuclear Forensic Investigation by Mayer, Klaus, Wallenius, Maria, Lützenkirchen, Klaus, Horta, Joan, Nicholl, Adrian, Rasmussen, Gert, van Belle, Pieter, Varga, Zsolt, Buda, Razvan, Erdmann, Nicole, Kratz, Jens-Volker, Trautmann, Norbert, Fifield, L. Keith, Tims, Stephen G., Fröhlich, Michaela B., Steier, Peter

“…Here we present a nuclear forensic study of uranium from German nuclear projects which used different geometries of metallic uranium fuel.3b,d, 4 Through…”
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Communication between Noncontacting Macromolecules by Völker, Jens, Klump, Horst H., Breslauer, Kenneth J.

“…We present a quantitative experimental demonstration of solventmediated communication between noncontacting biopolymers. We show that changes in the activity…”
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APE1 Incision Activity at Abasic Sites in Tandem Repeat Sequences by Li, Mengxia, Völker, Jens, Breslauer, Kenneth J., Wilson, David M.

“…Repetitive DNA sequences, such as those present in microsatellites and minisatellites, telomeres, and trinucleotide repeats (linked to fragile X syndrome,…”
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Conformational diversity of single-stranded DNA from bacterial repetitive extragenic palindromes: Implications for the DNA recognition elements of transposases by Charnavets, Tatsiana, Nunvar, Jaroslav, Nečasová, Iva, Völker, Jens, Breslauer, Kenneth J., Schneider, Bohdan

“…ABSTRACT Repetitive extragenic palindrome (REP)—associated tyrosine transposase enzymes (RAYTs) bind REP DNA domains and catalyze their cleavage. Genomic…”
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Erratum: "Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion" Biopolymers 101(1), 1-12, (2014) by Völker, Jens, Plum, G. Eric, Gindikin, Vera, Klump, Horst H., Breslauer, Kenneth J.

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