Search Results - "Vlodavsky, I."

Heparanase enhances myeloma progression via CXCL10 downregulation by Barash, U, Zohar, Y, Wildbaum, G, Beider, K, Nagler, A, Karin, N, Ilan, N, Vlodavsky, I

“…In order to explore the mechanism(s) underlying the pro-tumorigenic capacity of heparanase, we established an inducible Tet-on system. Heparanase expression…”
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Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models by Cassinelli, G., Lanzi, C., Tortoreto, M., Cominetti, D., Petrangolini, G., Favini, E., Zaffaroni, N., Pisano, C., Penco, S., Vlodavsky, I., Zunino, F.

“…The activity of heparanase is responsible for heparan sulfate cleavage, thus resulting in the release of heparan sulfate-bound growth factors. Since heparanase…”
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Tumor suppressor p53 regulates heparanase gene expression by Baraz, L, Haupt, Y, Elkin, M, Peretz, T, Vlodavsky, I

“…Mammalian heparanase degrades heparan sulfate, the most prominent polysaccharide of the extracellular matrix. Causal involvement of heparanase in tumor…”
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Increased expression of heparanase in overt diabetic nephropathy by van den Hoven, M.J., Rops, A.L., Bakker, M.A., Aten, J., Rutjes, N., Roestenberg, P., Goldschmeding, R., Zcharia, E., Vlodavsky, I., van der Vlag, J., Berden, J.H.

“…In overt diabetic nephropathy (DNP), an increase in the permeability of the glomerular basement membrane (GBM) has been associated with a loss of negatively…”
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Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes by Gibor, G., Ilan, N., Journo, S., Sharabi, A., Dreyer, J., Gertel, S., Singh, P., Menachem, A., Snir, N., Elkayam, O., Vlodavsky, I., Arad, U.

“…The chondrocytes' pericellular matrix acts as a mechanosensor by sequestering growth factors that are bound to heparan sulfate (HS) proteoglycans. Heparanase…”
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Heparanase induces tissue factor expression in vascular endothelial and cancer cells by NADIR, Y., BRENNER, B., ZETSER, A., ILAN, N., SHAFAT, I., ZCHARIA, E., GOLDSHMIDT, O., VLODAVSKY, I.

“…Background: Over‐expression of tissue factor (TF) and activation of the coagulation system are common in cancer patients. Heparanase is an…”
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Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients by Nadir, Y, Sarig, G, Axelman, E, Meir, A, Wollner, M, Shafat, I, Hoffman, R, Brenner, B, Vlodavsky, I, Haim, N

“…Abstract Background Heparanase is implicated in angiogenesis and tumor progression. We had earlier demonstrated that heparanase may also affect the hemostatic…”
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The role of heparanase in the metabolic responses of human articular chondrocytes by Gibor, G, Ilan, N, Journo, S, Elkayam, O, Vlodavsky, I, Arad, U

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Heparanase in glomerular diseases by van den Hoven, M.J., Rops, A.L., Vlodavsky, I., Levidiotis, V., Berden, J.H., van der Vlag, J.

“…Heparanase is an endo-β(1–4)-D-glucuronidase that degrades heparan sulfate (HS) polysaccharide side chains. The role of heparanase in metastasis, angiogenesis,…”
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Transgenic over-expression of mammalian heparanase delays prion disease onset and progression by Kovalchuk Ben-Zaken, O., Nissan, I., Tzaban, S., Taraboulos, A., Zcharia, E., Matzger, S., Shafat, I., Vlodavsky, I., Tal, Y.

“…Cellular heparan sulfate (HS) has a dual role in scrapie pathogenesis; it is required for PrPSc (scrapie prion protein) formation and facilitates infection of…”
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Heparanase as mediator of angiogenesis: mode of action by Elkin, Michael, Ilan, Neta, Ishai-Michaeli, Rivka, Friedmann, Yael, Papo, Orit, Pecker, Iris, Vlodavsky, Israel

“…ABSTRACT Extracellular matrix (ECM) and basement membranes (BMs) present a physical barrier that requires enzymatic degradation during endothelial cell (EC)…”
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Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies by OSTROVSKY, O, KOROSTISHEVSKY, M, LEVITE, I, LEIBA, M, GALSKI, H, VLODAVSKY, I, NAGLER, A

“…Heparanase, endo-beta-D-glucuronidase, degrades heparan sulfate glycosaminoglycans - the principal polysaccharide of the basement membrane and extracellular…”
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Halofuginone inhibits NF-κB and p38 MAPK in activated T cells by Leiba, M., Cahalon, L., Shimoni, A., Lider, O., Zanin‐Zhorov, A., Hecht, I., Sela, U., Vlodavsky, I., Nagler, A.

“…Halofuginone, a low molecular weight plant alkaloid, inhibits collagen α1 (I) gene expression in several animal models and in patients with fibrotic disease,…”
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Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors by Hunter, K E, Palermo, C, Kester, J C, Simpson, K, Li, J-P, Tang, L H, Klimstra, D S, Vlodavsky, I, Joyce, J A

“…Heparan sulfate proteoglycans are an important and abundant component of the extracellular matrix, which undergo substantial remodeling throughout…”
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Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria by van den Hoven, M.J., Wijnhoven, T.J., Li, J.-P., Zcharia, E., Dijkman, H.B., Wismans, R.G., Rops, A.L., Lensen, J.F., van den Heuvel, L.P., van Kuppevelt, T.H., Vlodavsky, I., Berden, J.H.M., van der Vlag, J.

“…Heparan sulfate in the glomerular basement membrane has been considered crucial for charge-selective filtration. In many proteinuric diseases, increased…”
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O50. Oral cancer prognostic markers by Leiser, Y, Abu-El Naaj, I, Vlodavsky, I, Peled, M

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Heparanase expression in periapical granulomas and radicular cysts by Elad, S., Sherman, Y., Palmon, A., Vlodavsky, I., Or, R.

“…Heparanase is an endo-β- d -glucuronidase enzyme which degrades heparan sulfate glycosaminoglycan side chains of proteoglycans in the extracellular matrix and…”
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Matrix Metalloproteinase 2 Releases Active Soluble Ectodomain of Fibroblast Growth Factor Receptor 1 by Levi, Ehud, Fridman, Rafael, Miao, Hua-Quan, Ma, Yong-Sheng, Yayon, Avner, Vlodavsky, Israel

“…Recent studies have demonstrated the existence of a soluble fibroblast growth factor (FGF) receptor type 1 (FGFR1) extracellular domain in the circulation and…”
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Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival by Bar-Sela, G, Kaplan-Cohen, V, Ilan, N, Vlodavsky, I, Ben-Izhak, O

“…Aim : To determine the expression and prognostic significance of heparanase in nasopharyngeal carcinoma (NPC). Methods : Immunohistochemistry was performed on…”
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923 HEPARANASE ACCELERATES PROLIFERATION OF BOTH HEPATOCYTES AND SINUSOIDAL ENDOTHELIAL CELLS AFTER PARTIAL HEPATECTOMY DESPITE IL-6 AND TNF-A DOWN REGULATION by Carmel, J, Arish, A, Ilan, N, Shoshany, G, Vlodavsky, I, Baruch, Y

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