Search Results - "Vlajkovic, Srdjan M"

Purinergic Signalling in the Cochlea by Vlajkovic, Srdjan M, Thorne, Peter R

“…The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from…”
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Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions by Tan, Winston J. T, Vlajkovic, Srdjan M

“…Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast,…”
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The Link between Gut Dysbiosis Caused by a High-Fat Diet and Hearing Loss by Kociszewska, Dagmara, Chan, Jeffrey, Thorne, Peter R, Vlajkovic, Srdjan M

“…This review aims to provide a conceptual and theoretical overview of the association between gut dysbiosis and hearing loss. Hearing loss is a global health…”
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Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics by Vlajkovic, Srdjan M., Thorne, Peter R.

“…The sense of hearing enables us to enjoy sounds and music and engage with other people [...]…”
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The Association of Inflammatory Gut Diseases with Neuroinflammatory and Auditory Disorders by Kociszewska, Dagmara, Vlajkovic, Srdjan M.

“…Disorders such as inflammatory bowel disease (IBD) and celiac disease (CeD) result in intestinal hyperpermeability or ‘leaky’ gut. The increased permeability…”
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A High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice by Chan, Jeffrey, Telang, Ravi, Kociszewska, Dagmara, Thorne, Peter R, Vlajkovic, Srdjan M

“…There is growing evidence for a relationship between gut dysbiosis and hearing loss. Inflammatory bowel disease, diet-induced obesity (DIO), and type 2…”
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Istradefylline Mitigates Age-Related Hearing Loss in C57BL/6J Mice by Shin, Min, Pandya, Madhavi, Espinosa, Kristan, Telang, Ravindra, Boix, Jordi, Thorne, Peter R., Vlajkovic, Srdjan M.

“…Age-related hearing loss (ARHL) is the most common sensory disorder among older people, and yet, the treatment options are limited to medical devices such as…”
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Regulator of G Protein Signalling 4 (RGS4) as a Novel Target for the Treatment of Sensorineural Hearing Loss by Fok, Christine, Bogosanovic, Milan, Pandya, Madhavi, Telang, Ravindra, Thorne, Peter R, Vlajkovic, Srdjan M

“…We and others have previously identified signalling pathways associated with the adenosine A receptor (A R) as important regulators of cellular responses to…”
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Editorial: Molecular mechanisms of sensorineural hearing loss and hearing protection by Vlajkovic, Srdjan M, Vélez-Ortega, A Catalina, Cederholm, Jennie M E

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ATP-gated ion channels mediate adaptation to elevated sound levels by Housley, Gary D., Morton-Jones, Rachel, Vlajkovic, Srdjan M., Telang, Ravindra S., Paramananthasivam, Vinthiya, Tadros, Sherif F., Wong, Ann Chi Yan, Froud, Kristina E., Cederholm, Jennie M. E., Sivakumaran, Yogeesan, Snguanwongchai, Peerawuth, Khakh, Baljit S., Cockayne, Debra A., Thorne, Peter R., Ryan, Allen F.

“…The sense of hearing is remarkable for its auditory dynamic range, which spans more than 10 ¹² in acoustic intensity. The mechanisms that enable the cochlea to…”
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Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival by Lin, Shelly C Y, Thorne, Peter R, Housley, Gary D, Vlajkovic, Srdjan M

“…Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides…”
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Inhibition of the Adenosine A2A Receptor Mitigates Excitotoxic Injury in Organotypic Tissue Cultures of the Rat Cochlea by Han, Belinda RX, Lin, Shelly CY, Espinosa, Kristan, Thorne, Peter R, Vlajkovic, Srdjan M

“…The primary loss of cochlear glutamatergic afferent nerve synapses due to noise or ageing (cochlear neuropathy) often presents as difficulties in speech…”
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Kölliker’s Organ and the Development of Spontaneous Activity in the Auditory System : Implications for Hearing Dysfunction by Dayaratne, M. W. Nishani, Vlajkovic, Srdjan M., Lipski, Janusz, Thorne, Peter R.

“…Prior to the “onset of hearing,” developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is…”
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Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss by Vlajkovic, Srdjan M., Guo, Cindy X., Telang, Ravindra, Wong, Ann Chi Yan, Paramananthasivam, Vinthiya, Boison, Detlev, Housley, Gary D., Thorne, Peter R.

“…This study was undertaken to determine the role of adenosine signalling in the development of age-related hearing loss (ARHL). We and others have shown…”
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Characterisation of cochlear inflammation in mice following acute and chronic noise exposure by Tan, Winston J. T., Thorne, Peter R., Vlajkovic, Srdjan M.

“…Oxidative stress has been established as the key mechanism of the cochlear damage underlying noise-induced hearing loss, however, emerging evidence suggests…”
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Role of adenosine kinase in cochlear development and response to noise by Vlajkovic, Srdjan M., Guo, Cindy X., Dharmawardana, Nuwan, Wong, Ann Chi Yan, Boison, Detlev, Housley, Gary D., Thorne, Peter R.

“…Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary…”
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The developmental journey of therapies targeting purine receptors: from basic science to clinical trials by Han, Seunga, Suzuki-Kerr, Haruna, Vlajkovic, Srdjan M., Thorne, Peter R.

“…Since the discovery of ATP as an extracellular signalling molecule in 1972, purinergic signalling, mediated by extracellular purines and pyrimidines has been…”
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Editorial: purinergic signalling—perspectives from Australia and New Zealand by Sluyter, Ronald, Cederholm, Jennie M. E., Vlajkovic, Srdjan M.

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Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model by Lloyd, Jordan T., Yee, Andrew G., Kalligappa, Prasanna K., Jabed, Anower, Cheung, Pang Y., Todd, Kathryn L., Karunasinghe, Rashika N., Vlajkovic, Srdjan M., Freestone, Peter S., Lipski, Janusz

“…•Our genetic model extends the range of animals for dopamine dysregulation studies.•Voltammetry was used to measure dopamine both in the striatum and…”
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Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss by Vlajkovic, Srdjan M., Ambepitiya, Kaushi, Barclay, Meagan, Boison, Detlev, Housley, Gary D., Thorne, Peter R.

“…Our previous studies have shown that the stimulation of A1 adenosine receptors in the inner ear can mitigate the loss of sensory hair cells and hearing loss…”
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