Search Results - "Vladimer, Gregory I."

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses by Köberlin, Marielle S., Snijder, Berend, Heinz, Leonhard X., Baumann, Christoph L., Fauster, Astrid, Vladimer, Gregory I., Gavin, Anne-Claude, Superti-Furga, Giulio

“…Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory…”
Get full text

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms by Klampfl, Thorsten, Gisslinger, Heinz, Harutyunyan, Ashot S, Nivarthi, Harini, Rumi, Elisa, Milosevic, Jelena D, Them, Nicole C.C, Berg, Tiina, Gisslinger, Bettina, Pietra, Daniela, Chen, Doris, Vladimer, Gregory I, Bagienski, Klaudia, Milanesi, Chiara, Casetti, Ilaria Carola, Sant'Antonio, Emanuela, Ferretti, Virginia, Elena, Chiara, Schischlik, Fiorella, Cleary, Ciara, Six, Melanie, Schalling, Martin, Schönegger, Andreas, Bock, Christoph, Malcovati, Luca, Pascutto, Cristiana, Superti-Furga, Giulio, Cazzola, Mario, Kralovics, Robert

“…The authors identified calreticulin mutations in the majority of patients with essential thrombocythemia and myelofibrosis who did not have JAK2 mutations. The…”
Get full text

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants by Marty-Roix, Robyn, Vladimer, Gregory I., Pouliot, Kimberly, Weng, Dan, Buglione-Corbett, Rachel, West, Kim, MacMicking, John D., Chee, Jonathan D., Wang, Shixia, Lu, Shan, Lien, Egil

“…Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules…”
Get full text

LZTR1 is a regulator of RAS ubiquitination and signaling by Bigenzahn, Johannes W, Collu, Giovanna M, Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I, Heinz, Leonhard X, Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A, Müller, André C, Winter, Georg E, Kralovics, Robert, Brummelkamp, Thijn R, Mlodzik, Marek, Superti-Furga, Giulio

“…In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding…”
Get full text

The NLRP12 Inflammasome Recognizes Yersinia pestis by Vladimer, Gregory I., Weng, Dan, Paquette, Sara W. Montminy, Vanaja, Sivapriya Kailasan, Rathinam, Vijay A.K., Aune, Marie Hjelmseth, Conlon, Joseph E., Burbage, Joseph J., Proulx, Megan K., Liu, Qin, Reed, George, Mecsas, Joan C., Iwakura, Yoichiro, Bertin, John, Goguen, Jon D., Fitzgerald, Katherine A., Lien, Egil

“…Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory cytokines IL-18 and IL-1β, which are generated through…”
Get full text

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death by Weng, Dan, Marty-Roix, Robyn, Ganesan, Sandhya, Proulx, Megan K., Vladimer, Gregory I., Kaiser, William J., Mocarski, Edward S., Pouliot, Kimberly, Chan, Francis Ka-Ming, Kelliher, Michelle A., Harris, Phillip A., Bertin, John, Gough, Peter J., Shayakhmetov, Dmitry M., Goguen, Jon D., Fitzgerald, Katherine A., Silverman, Neal, Lien, Egil

“…A number of pathogens cause host cell death upon infection, and Yersinia pestis , infamous for its role in large pandemics such as the “Black Death” in…”
Get full text

Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions by Valent, Peter, Orazi, Attilio, Savona, Michael R, Patnaik, Mrinal M, Onida, Francesco, van de Loosdrecht, Arjan A, Haase, Detlef, Haferlach, Torsten, Elena, Chiara, Pleyer, Lisa, Kern, Wolfgang, Pemovska, Tea, Vladimer, Gregory I, Schanz, Julie, Keller, Alexandra, Lübbert, Michael, Lion, Thomas, Sotlar, Karl, Reiter, Andreas, De Witte, Theo, Pfeilstöcker, Michael, Geissler, Klaus, Padron, Eric, Deininger, Michael, Orfao, Alberto, Horny, Hans-Peter, Greenberg, Peter L, Arber, Daniel A, Malcovati, Luca, Bennett, John M

“…Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by dysplasia, abnormal production and accumulation of monocytic cells and an…”
Get full text

A Role for the Adaptor Proteins TRAM and TRIF in Toll-like Receptor 2 Signaling by Nilsen, Nadra J., Vladimer, Gregory I., Stenvik, Jørgen, Orning, M. Pontus A., Zeid-Kilani, Maria V., Bugge, Marit, Bergstroem, Bjarte, Conlon, Joseph, Husebye, Harald, Hise, Amy G., Fitzgerald, Katherine A., Espevik, Terje, Lien, Egil

“…Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and…”
Get full text

IFITs: Emerging Roles as Key Anti-Viral Proteins by Vladimer, Gregory I, Górna, Maria W, Superti-Furga, Giulio

“…Interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of proteins, which are strongly induced downstream of type I interferon…”
Get full text

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client by Bigenzahn, Johannes W., Fauster, Astrid, Rebsamen, Manuele, Kandasamy, Richard K., Scorzoni, Stefania, Vladimer, Gregory I., Müller, André C., Gstaiger, Matthias, Zuber, Johannes, Bennett, Keiryn L., Superti-Furga, Giulio

“…Tandem affinity purification–mass spectrometry (TAP-MS) is a popular strategy for the identification of protein–protein interactions, characterization of…”
Get full text

Inflammasomes and host defenses against bacterial infections by Vladimer, Gregory I, Marty-Roix, Robyn, Ghosh, Shubhendu, Weng, Dan, Lien, Egil

“…Highlights ► The inflammasomes are central for many anti-bacterial host defenses. ► In addition to caspase-1, caspase-11 and caspase-8 are emerging as…”
Get full text

The NLRP12 Inflammasome Recognizes Yersinia pestis by Vladimer, Gregory I., Weng, Dan, Paquette, Sara W. Montminy, Vanaja, Sivapriya Kailasan, Rathinam, Vijay A.K., Aune, Marie Hjelmseth, Conlon, Joseph E., Burbage, Joseph J., Proulx, Megan K., Liu, Qin, Reed, George, Mecsas, Joan C., Iwakura, Yoichiro, Bertin, John, Goguen, Jon D., Fitzgerald, Katherine A., Lien, Egil

Get full text

Patient-derived model systems and the development of next-generation anticancer therapeutics by Krall, Nikolaus, Superti-Furga, Giulio, Vladimer, Gregory I.

“…Anticancer drug discovery and development using conventional cell line and animal models has traditionally had a low overall success rate. Despite yielding…”
Get full text

Influence of cryopreservation on drug responses and gene expression of AML cells: Implications for the use of biobanked tissues by Meszaros, Noemi, Lind, Karin, Sehlke, Robert, Vilagos, Bojan, Krall, Nikolaus, Vladimer, Gregory I., Sill, Heinz

Get full text

Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders by Kornauth, Christoph, Pemovska, Tea, Vladimer, Gregory I, Bayer, Günther, Bergmann, Michael, Eder, Sandra, Eichner, Ruth, Erl, Martin, Esterbauer, Harald, Exner, Ruth, Felsleitner-Hauer, Verena, Forte, Maurizio, Gaiger, Alexander, Geissler, Klaus, Greinix, Hildegard T, Gstöttner, Wolfgang, Hacker, Marcus, Hartmann, Bernd Lorenz, Hauswirth, Alexander W, Heinemann, Tim, Heintel, Daniel, Hoda, Mir Alireza, Hopfinger, Georg, Jaeger, Ulrich, Kazianka, Lukas, Kenner, Lukas, Kiesewetter, Barbara, Krall, Nikolaus, Krajnik, Gerhard, Kubicek, Stefan, Le, Trang, Lubowitzki, Simone, Mayerhoefer, Marius E, Menschel, Elisabeth, Merkel, Olaf, Miura, Katsuhiro, Müllauer, Leonhard, Neumeister, Peter, Noesslinger, Thomas, Ocko, Katharina, Öhler, Leopold, Panny, Michael, Pichler, Alexander, Porpaczy, Edit, Prager, Gerald W, Raderer, Markus, Ristl, Robin, Ruckser, Reinhard, Salamon, Julius, Schiefer, Ana-Iris, Schmolke, Ann-Sofie, Schwarzinger, Ilse, Selzer, Edgar, Sillaber, Christian, Skrabs, Cathrin, Sperr, Wolfgang R, Srndic, Ismet, Thalhammer, Renate, Valent, Peter, van der Kouwe, Emiel, Vanura, Katrina, Vogt, Stefan, Waldstein, Cora, Wolf, Dominik, Zielinski, Christoph C, Zojer, Niklas, Simonitsch-Klupp, Ingrid, Superti-Furga, Giulio, Snijder, Berend, Staber, Philipp B

“…Personalized medicine aims to match the right drug with the right patient by using specific features of the individual patient's tumor. However, current…”
Get more information

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity by Willmann, Katharina L., Klaver, Stefanie, Doğu, Figen, Santos-Valente, Elisangela, Garncarz, Wojciech, Bilic, Ivan, Mace, Emily, Salzer, Elisabeth, Domínguez Conde, Cecilia, Sic, Heiko, Májek, Peter, Banerjee, Pinaki P., Vladimer, Gregory I., Haskoloğlu, Şule, Gökalp Bolkent, Musa, Küpesiz, Alphan, Condino-Neto, Antonio, Colinge, Jacques, Superti-Furga, Giulio, Pickl, Winfried F., van Zelm, Menno C., Eibel, Hermann, Orange, Jordan S., Ikincioğulları, Aydan, Boztuğ, Kaan

“…Primary immunodeficiency disorders enable identification of genes with crucial roles in the human immune system. Here we study patients suffering from…”
Get full text

Global survey of the immunomodulatory potential of common drugs by Vladimer, Gregory I, Snijder, Berend, Krall, Nikolaus, Bigenzahn, Johannes W, Huber, Kilian V M, Lardeau, Charles-Hugues, Sanjiv, Kumar, Ringler, Anna, Berglund, Ulrika Warpman, Sabler, Monika, de la Fuente, Oscar Lopez, Knöbl, Paul, Kubicek, Stefan, Helleday, Thomas, Jäger, Ulrich, Superti-Furga, Giulio

“…A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the…”
Get full text

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL by Schmidl, Christian, Vladimer, Gregory I., Rendeiro, André F., Schnabl, Susanne, Krausgruber, Thomas, Taubert, Christina, Krall, Nikolaus, Pemovska, Tea, Araghi, Mohammad, Snijder, Berend, Hubmann, Rainer, Ringler, Anna, Runggatscher, Kathrin, Demirtas, Dita, de la Fuente, Oscar Lopez, Hilgarth, Martin, Skrabs, Cathrin, Porpaczy, Edit, Gruber, Michaela, Hoermann, Gregor, Kubicek, Stefan, Staber, Philipp B., Shehata, Medhat, Superti-Furga, Giulio, Jäger, Ulrich, Bock, Christoph

“…The Bruton tyrosine kinase (BTK) inhibitor ibrutinib has substantially improved therapeutic options for chronic lymphocytic leukemia (CLL). Although ibrutinib…”
Get full text

Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study by Snijder, Berend, Vladimer, Gregory I, Krall, Nikolaus, Miura, Katsuhiro, Schmolke, Ann-Sofie, Kornauth, Christoph, Lopez de la Fuente, Oscar, Choi, Hye-Soo, van der Kouwe, Emiel, Gültekin, Sinan, Kazianka, Lukas, Bigenzahn, Johannes W, Hoermann, Gregor, Prutsch, Nicole, Merkel, Olaf, Ringler, Anna, Sabler, Monika, Jeryczynski, Georg, Mayerhoefer, Marius E, Simonitsch-Klupp, Ingrid, Ocko, Katharina, Felberbauer, Franz, Müllauer, Leonhard, Prager, Gerald W, Korkmaz, Belgin, Kenner, Lukas, Sperr, Wolfgang R, Kralovics, Robert, Gisslinger, Heinz, Valent, Peter, Kubicek, Stefan, Jäger, Ulrich, Staber, Philipp B, Superti-Furga, Giulio

“…Patients with refractory or relapsed haematological malignancies have few treatment options and short survival times. Identification of effective therapies…”
Get full text

Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation by Schmidt-Lauber, Christian, Bossaller, Lukas, Abujudeh, Hani H, Vladimer, Gregory I, Christ, Anette, Fitzgerald, Katherine A, Latz, Eicke, Gravallese, Ellen M, Marshak-Rothstein, Ann, Kay, Jonathan

“…Nephrogenic systemic fibrosis (NSF) is a progressive fibrosing disorder that may develop in patients with chronic kidney disease after administration of…”
Get more information