Search Results - "Vladimír LANDA"

Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats by Liška, František, Peterková, Renata, Peterka, Miroslav, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Křen, Vladimír, Starker, Colby G, Voytas, Daniel F, Izsvák, Zsuzsanna, Pravenec, Michal

“…[This corrects the article DOI: 10.1371/journal.pone.0164206.]…”
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Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons by Ivics, Zoltán, Garrels, Wiebke, Mátés, Lajos, Yau, Tien Yin, Bashir, Sanum, Zidek, Vaclav, Landa, Vladimír, Geurts, Aron, Pravenec, Michal, Rülicke, Thomas, Kues, Wilfried A, Izsvák, Zsuzsanna

“…The pig has emerged as an important large animal model in biomedical and pharmaceutical research. We describe a protocol for high-efficiency germline…”
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Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein by Malínská, Hana, Oliyarnyk, Olena, Škop, Vojtěch, Šilhavý, Jan, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Kazdová, Ludmila, Pravenec, Michal

“…Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for…”
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Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat by Liška, František, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Strnad, Hynek, Trnovská, Jaroslava, Škop, Vojtěch, Kazdová, Ludmila, Starker, Colby G, Voytas, Daniel F, Izsvák, Zsuzsanna, Mancini, Massimiliano, Šeda, Ondřej, Křen, Vladimír, Pravenec, Michal

“…The spontaneously hypertensive rat (SHR), one of the most widely used model of essential hypertension, is predisposed to left ventricular hypertrophy,…”
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Fumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats by Šilhavý, Jan, Zídek, Václav, Mlejnek, Petr, Landa, Vladimír, Šimáková, Miroslava, Strnad, Hynek, Oliyarnyk, Olena, Škop, Vojtěch, Kazdová, Ludmila, Kurtz, Theodore, Pravenec, Michal

“…Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit…”
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Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome by Pravenec, Michal, Kajiya, Takashi, Zídek, Václav, Landa, Vladimír, Mlejnek, Petr, Šimáková, Miroslava, Šilhavý, Jan, Malínská, Hana, Oliyarnyk, Olena, Kazdová, Ludmila, Fan, Jianglin, Wang, Jiaming, Kurtz, Theodore W

“…Major controversy exists as to whether increased C-reactive protein (CRP) contributes to individual components of the metabolic syndrome or is just a secondary…”
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Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls by Trnovská, Jaroslava, Šilhavý, Jan, Kuda, Ondřej, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Škop, Vojtěch, Oliyarnyk, Olena, Kazdová, Ludmila, Haluzík, Martin, Pravenec, Michal

“…Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a…”
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Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats by Liška, František, Peterková, Renata, Peterka, Miroslav, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Křen, Vladimír, Starker, Colby G, Voytas, Daniel F, Izsvák, Zsuzsanna, Pravenec, Michal

“…Recently, it has been found that spontaneous mutation Lx (polydactyly-luxate syndrome) in the rat is determined by deletion of a conserved intronic sequence of…”
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Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats by Pravenec, Michal, Kožich, Viktor, Krijt, Jakub, Sokolová, Jitka, Zídek, Václav, Landa, Vladimír, Šimáková, Miroslava, Mlejnek, Petr, Šilhavý, Jan, Oliyarnyk, Olena, Kazdová, Ludmila, Kurtz, Theodore W.

“…BACKGROUND The role of folate deficiency and associated hyperhomocysteinemia in the pathogenesis of metabolic syndrome is not fully established. In the current…”
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Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility by Mihola, Ondrej, Landa, Vladimir, Pratto, Florencia, Brick, Kevin, Kobets, Tatyana, Kusari, Fitore, Gasic, Srdjan, Smagulova, Fatima, Grey, Corinne, Flachs, Petr, Gergelits, Vaclav, Tresnak, Karel, Silhavy, Jan, Mlejnek, Petr, Camerini-Otero, R Daniel, Pravenec, Michal, Petukhova, Galina V, Trachtulec, Zdenek

“…Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of…”
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Transposon‐mediated transgenesis, transgenic rescue, and tissue‐specific gene expression in rodents and rabbits by Katter, Katharina, Geurts, Aron M., Hoffmann, Orsolya, Mátés, Lajos, Landa, Vladimir, Hiripi, László, Moreno, Carol, Lazar, Jozef, Bashir, Sanum, Zidek, Vaclav, Popova, Elena, Jerchow, Boris, Becker, Katja, Devaraj, Anantharam, Walter, Ingrid, Grzybowksi, Michael, Corbett, Molly, Filho, Artur Rangel, Hodges, Matthew R., Bader, Michael, Ivics, Zoltán, Jacob, Howard J., Pravenec, Michal, Bősze, Zsuzsanna, Rülicke, Thomas, Izsvák, Zsuzsanna

“…Germline transgenesis is an important procedure for functional investigation of biological pathways, as well as for animal biotechnology. We have established a…”
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Plzf as a candidate gene predisposing the spontaneously hypertensive rat to hypertension, left ventricular hypertrophy, and interstitial fibrosis by Liška, František, Mancini, Massimiliano, Krupková, Michaela, Chylíková, Blanka, Křenová, Drahomíra, Šeda, Ondřej, Šilhavý, Jan, Mlejnek, Petr, Landa, Vladimír, Zídek, Václav, d' Amati, Giulia, Pravenec, Michal, Křen, Vladimír

“…The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is susceptible to left ventricular hypertrophy (LVH) and…”
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Systems genetic analysis of brown adipose tissue function by Pravenec, Michal, Saba, Laura M, Zídek, Václav, Landa, Vladimír, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Strnad, Hynek, Trnovská, Jaroslava, Škop, Vojtěch, Hüttl, Martina, Marková, Irena, Oliyarnyk, Olena, Malínská, Hana, Kazdová, Ludmila, Smith, Harry, Tabakoff, Boris

“…Brown adipose tissue (BAT) has been suggested to play an important role in lipid and glucose metabolism in rodents and possibly also in humans. In the current…”
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Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome by Pravenec, Michal, Kožich, Viktor, Krijt, Jakub, Sokolová, Jitka, Zídek, Václav, Landa, Vladimír, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Škop, Vojtěch, Trnovská, Jaroslava, Kazdová, Ludmila, Kajiya, Takashi, Wang, Jiaming, Kurtz, Theodore W

“…Metabolism of homocysteine and other sulfur amino acids is closely associated with metabolism of folates. In this study, we analyzed the possible role of…”
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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension by Kurtz, Theodore W, Pravenec, Michal, Churchill, Paul C, Churchill, Monique C, Viklicky, Ondrej, Kazdova, Ludmila, Aitman, Timothy J, Petretto, Enrico, Hubner, Norbert, Wallace, Caroline A, Zimdahl, Heike, Zidek, Vaclav, Landa, Vladimir, Dunbar, Joseph, Bidani, Anil, Griffin, Karen, Qi, Nathan, Maxova, Martina, Kren, Vladimir, Mlejnek, Petr, Wang, Jiaming

“…To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with…”
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Transgenic and Recombinant Resistin Impair Skeletal Muscle Glucose Metabolism in the Spontaneously Hypertensive Rat by Pravenec, Michal, Kazdová, Ludmila, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Jansa, Petr, Wang, Jiaming, Qi, Nianning, Kurtz, Theodore W.

“…Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance…”
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Generation and phenotypic analysis of a transgenic line of rabbits secreting active recombinant human erythropoietin in the milk by MIKUS, Tomas, POPLSTEIN, Martin, SEDLAKOVA, Jirina, LANDA, Vladimir, JENIKOVA, Gabriela, TREFIL, Pavel, LIDICKY, Jan, MALY, Petr

“…Production of recombinant human erythropoietin (rhEPO) for therapeutic purposes relies on its expression in selected clones of transfected mammalian cells…”
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Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue by Pravenec, Michal, Mlejnek, Petr, Zídek, Václav, Landa, Vladimír, Šimáková, Miroslava, Šilhavý, Jan, Strnad, Hynek, Eigner, Sebastian, Eigner Henke, Kateřina, Škop, Vojtěch, Malínská, Hana, Trnovská, Jaroslava, Kazdová, Ludmila, Drahota, Zdeněk, Mráček, Tomáš, Houštěk, Josef

“…Resistin has been originally identified as an adipokine that links obesity to insulin resistance in mice. In our previous studies in spontaneously hypertensive…”
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Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons by Ivics, Zoltán, Mátés, Lajos, Yau, Tien Yin, Landa, Vladimír, Zidek, Vaclav, Bashir, Sanum, Hoffmann, Orsolya I, Hiripi, László, Garrels, Wiebke, Kues, Wilfried A, Bösze, Zsuzsanna, Geurts, Aron, Pravenec, Michal, Rülicke, Thomas, Izsvák, Zsuzsanna

“…We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in two important biomedical models, the mouse and the rat,…”
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Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons by Ivics, Zoltán, Hiripi, László, Hoffmann, Orsolya I, Mátés, Lajos, Yau, Tien Yin, Bashir, Sanum, Zidek, Vaclav, Landa, Vladimír, Geurts, Aron, Pravenec, Michal, Rülicke, Thomas, Bösze, Zsuzsanna, Izsvák, Zsuzsanna

“…The laboratory rabbit ( Oryctolagus cuniculus ) is widely used as a model for a variety of inherited and acquired human diseases. In addition, the rabbit is…”
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