Search Results - "Vlachy, Vojko"

Explicit-water theory for the salt-specific effects and Hofmeister series in protein solutions by Kalyuzhnyi, Yuriy V, Vlachy, Vojko

“…Effects of addition of salts on stability of aqueous protein solutions are studied theoretically and the results are compared with experimental data. In our…”
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Protein aggregation in salt solutions by Kastelic, Miha, Kalyuzhnyi, Yurij V., Hribar-Lee, Barbara, Dill, Ken A., Vlachy, Vojko

“…Protein aggregation is broadly important in diseases and in formulations of biological drugs. Here, we develop a theoretical model for reversible…”
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Protein Association in Solution: Statistical Mechanical Modeling by Vlachy, Vojko, Kalyuzhnyi, Yurij V, Hribar-Lee, Barbara, Dill, Ken A

“…Protein molecules associate in solution, often in clusters beyond pairwise, leading to liquid phase separations and high viscosities. It is often impractical…”
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Effects of the translational and rotational degrees of freedom on the hydration of simple solutes by Mohorič, Tomaž, Hribar-Lee, Barbara, Vlachy, Vojko

“…Molecular dynamics simulations with separate thermostats for rotational and translational motion were used to study the effect of these degrees of freedom on…”
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Ionic effects beyond Poisson-Boltzmann theory by Vlachy, V

“…Polyelectrolytes are electrolytes asymmetric both in charge and size. Their properties in solution are dominated by Coulombic forces, and without a detailed…”
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Effects of Translational and Rotational Degrees of Freedom on the Hydration of Ionic Solutes as Seen by the Popular Water Models by Mohorič, Tomaž, Bren, Urban, Vlachy, Vojko

“…We employed molecular dynamics simulations with separate thermostats for translational and rotational temperatures in order to study the effects of these…”
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Counter-ion binding and mobility in the presence of hydrophobic polyions – combining molecular dynamics simulations and NMR by Druchok, Maksym, Malikova, Natalie, Rollet, Anne-Laure, Vlachy, Vojko

“…Counter-ion binding and mobility in aqueous solutions of partially hydrophobic ionene oligoions is studied here by a combination of all-atomic molecular…”
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Thermodynamics of the Lysozyme−Salt Interaction from Calorimetric Titrations by Bončina, Matjaž, Lah, Jurij, Reščič, Jurij, Vlachy, Vojko

“…It is well-known that the addition of salts influences the properties of proteins in solution. The essential nature of this phenomenon is far from being fully…”
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Ion-specific and charge effects in counterion binding to poly(styrenesulfonate) anions by Požar, Josip, Bohinc, Klemen, Vlachy, Vojko, Kovačević, Davor

“…In order to obtain a deeper insight into effects occurring when an electrolyte solution is added to a solution of a strong polyelectrolyte, the…”
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Theory for the Liquid–Liquid Phase Separation in Aqueous Antibody Solutions by Kastelic, Miha, Vlachy, Vojko

“…This study presents the theory for liquid–liquid phase separation for systems of molecules modeling monoclonal antibodies. Individual molecule is depicted as…”
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Numerical analysis of the liquid-liquid phase separation in the antibody–human serum albumin mixtures in aqueous buffer solution by Kalyuzhnyi, Yurij V., Vlachy, Vojko

“…•Numerical analysis of the phase behavior of the antibody-human serum albumin mixtures is carried out.•Properties of the system are governed by the…”
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On the contact conditions for the density and charge profiles in the theory of electrical double layer: From planar to spherical and cylindrical geometry by Holovko, Myroslav, Vlachy, Vojko, di Caprio, Dung

“…•Two approaches describe density and charge profiles in the electric double layer.•The contact theorems for the density and charge profiles are formulated.•In…”
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Modelling bi-specific antibodies in aqueous solution by Hvozd, Taras, Kalyuzhnyi, Yurij V., Vlachy, Vojko

“…This study presents theoretical results for physico-chemical properties of system of molecules modeling bi-specific antibodies, such as, dual-variable-domain…”
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Osmotic Pressure, Small-Angle X-Ray, and Dynamic Light Scattering Studies of Human Serum Albumin in Aqueous Solutions by Reščič, Jurij, Vlachy, Vojko, Jamnik, Andrej, Glatter, Otto

“…Osmotic pressure measurements of human serum albumin (HSA) dissolved in water and in 0.01, 0.1, and 1.0 M phosphate buffer are reported as a function of the…”
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Ion Pairing in Molecular Simulations of Aqueous Alkali Halide Solutions by Fennell, Christopher J, Bizjak, Alan, Vlachy, Vojko, Dill, Ken A

“…Using classical molecular dynamics simulations, we study ion−ion interactions in water. We study the potentials of mean force (PMF) for the full set of alkali…”
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Polyelectrolyte hydration: Theory and experiment by Vlachy, Vojko

“…A short review of recent theoretical and experimental advances in studies of polyelectrolyte solutions is presented. The focus is on ion-specific effects as…”
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Controlling the viscosities of antibody solutions through control of their binding sites by Kastelic, Miha, Dill, Ken A., Kalyuzhnyi, Yura V., Vlachy, Vojko

“…For biotechnological drugs, it is desirable to formulate antibody solutions with low viscosities. We go beyond previous colloid theories in treating…”
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Calorimetric studies of interactions between low molecular weight salts and bovine serum albumin in water at pH values below and above the isoionic point by Janc, Tadeja, Vlachy, Vojko, Lukšič, Miha

“…Isothermal titration calorimetry was used to determine the temperature and salt concentration dependence of the enthalpy of mixing, ΔmixH, of bovine serum…”
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Modeling water, the hydrophobic effect, and ion solvation by Dill, Ken A, Truskett, Thomas M, Vlachy, Vojko, Hribar-Lee, Barbara

“…Water plays a central role in the structures and properties of biomolecules--proteins, nucleic acids, and membranes--and in their interactions with ligands and…”
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Calorimetric studies of interactions between low molecular weight salts and bovine serum albumin in water at p H values below and above the isoionic point by Janc, Tadeja, Vlachy, Vojko, Lukšič, Miha

“…Isothermal titration calorimetry was used to determine the temperature and salt concentration dependence of the enthalpy of mixing, Δ , of bovine serum albumin…”
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