Search Results - "Vkovski, Philip"

APOBEC3-mediated restriction of RNA virus replication by Milewska, Aleksandra, Kindler, Eveline, Vkovski, Philip, Zeglen, Slawomir, Ochman, Marek, Thiel, Volker, Rajfur, Zenon, Pyrc, Krzysztof

“…APOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other…”
Get full text

Coronavirus biology and replication: implications for SARS-CoV-2 by V’kovski, Philip, Kratzel, Annika, Steiner, Silvio, Stalder, Hanspeter, Thiel, Volker

“…The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive impact has marked the third zoonotic introduction of a highly pathogenic…”
Get full text

Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols by Kratzel, Annika, Todt, Daniel, V'kovski, Philip, Steiner, Silvio, Gultom, Mitra, Thao, Tran Thi Nhu, Ebert, Nadine, Holwerda, Melle, Steinmann, Jörg, Niemeyer, Daniela, Dijkman, Ronald, Kampf, Günter, Drosten, Christian, Steinmann, Eike, Thiel, Volker, Pfaender, Stephanie

“…Infection control instructions call for use of alcohol-based hand rub solutions to inactivate severe acute respiratory syndrome coronavirus 2. We determined…”
Get full text

Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle by Cong, Yingying, Ulasli, Mustafa, Schepers, Hein, Mauthe, Mario, V'kovski, Philip, Kriegenburg, Franziska, Thiel, Volker, de Haan, Cornelis A M, Reggiori, Fulvio

“…Coronavirus (CoV) nucleocapsid (N) proteins are key for incorporating genomic RNA into progeny viral particles. In infected cells, N proteins are present at…”
Get full text

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets by Kratzel, Annika, Kelly, Jenna N, V'kovski, Philip, Portmann, Jasmine, Brüggemann, Yannick, Todt, Daniel, Ebert, Nadine, Shrestha, Neeta, Plattet, Philippe, Staab-Weijnitz, Claudia A, von Brunn, Albrecht, Steinmann, Eike, Dijkman, Ronald, Zimmer, Gert, Pfaender, Stephanie, Thiel, Volker

“…Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged-Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East…”
Get full text

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium by V'kovski, Philip, Gultom, Mitra, Kelly, Jenna N, Steiner, Silvio, Russeil, Julie, Mangeat, Bastien, Cora, Elisa, Pezoldt, Joern, Holwerda, Melle, Kratzel, Annika, Laloli, Laura, Wider, Manon, Portmann, Jasmine, Tran, Thao, Ebert, Nadine, Stalder, Hanspeter, Hartmann, Rune, Gardeux, Vincent, Alpern, Daniel, Deplancke, Bart, Thiel, Volker, Dijkman, Ronald

“…Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden…”
Get full text

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform by Thi Nhu Thao, Tran, Labroussaa, Fabien, Ebert, Nadine, V’kovski, Philip, Stalder, Hanspeter, Portmann, Jasmine, Kelly, Jenna, Steiner, Silvio, Holwerda, Melle, Kratzel, Annika, Gultom, Mitra, Schmied, Kimberly, Laloli, Laura, Hüsser, Linda, Wider, Manon, Pfaender, Stephanie, Hirt, Dagny, Cippà, Valentina, Crespo-Pomar, Silvia, Schröder, Simon, Muth, Doreen, Niemeyer, Daniela, Corman, Victor M., Müller, Marcel A., Drosten, Christian, Dijkman, Ronald, Jores, Joerg, Thiel, Volker

“…Reverse genetics has been an indispensable tool to gain insights into viral pathogenesis and vaccine development. The genomes of large RNA viruses, such as…”
Get full text

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling by V'kovski, Philip, Gerber, Markus, Kelly, Jenna, Pfaender, Stephanie, Ebert, Nadine, Braga Lagache, Sophie, Simillion, Cedric, Portmann, Jasmine, Stalder, Hanspeter, Gaschen, Véronique, Bruggmann, Rémy, Stoffel, Michael H, Heller, Manfred, Dijkman, Ronald, Thiel, Volker

“…Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins…”
Get full text

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication by Kindler, Eveline, Gil-Cruz, Cristina, Spanier, Julia, Li, Yize, Wilhelm, Jochen, Rabouw, Huib H, Züst, Roland, Hwang, Mihyun, V'kovski, Philip, Stalder, Hanspeter, Marti, Sabrina, Habjan, Matthias, Cervantes-Barragan, Luisa, Elliot, Ruth, Karl, Nadja, Gaughan, Christina, van Kuppeveld, Frank J M, Silverman, Robert H, Keller, Markus, Ludewig, Burkhard, Bergmann, Cornelia C, Ziebuhr, John, Weiss, Susan R, Kalinke, Ulrich, Thiel, Volker

“…Coronaviruses are of veterinary and medical importance and include highly pathogenic zoonotic viruses, such as SARS-CoV and MERS-CoV. They are known to…”
Get full text

Hidden Behind Autophagy: The Unconventional Roles of ATG Proteins by Bestebroer, Jovanka, V'kovski, Philip, Mauthe, Mario, Reggiori, Fulvio

“…The transport pathway of autophagy is characterized by double‐membrane vesicles called autophagosomes, which are formed through the concerted action of the…”
Get full text

Proximity Labeling for the Identification of Coronavirus-Host Protein Interactions by V'kovski, Philip, Steiner, Silvio, Thiel, Volker

“…Biotin-based proximity labeling circumvents major pitfalls of classical biochemical approaches to identify protein-protein interactions. It consists of…”
Get more information

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation by Tabata, Keisuke, Prasad, Vibhu, Paul, David, Lee, Ji-Young, Pham, Minh-Tu, Twu, Woan-Ing, Neufeldt, Christopher J., Cortese, Mirko, Cerikan, Berati, Stahl, Yannick, Joecks, Sebastian, Tran, Cong Si, Lüchtenborg, Christian, V’kovski, Philip, Hörmann, Katrin, Müller, André C., Zitzmann, Carolin, Haselmann, Uta, Beneke, Jürgen, Kaderali, Lars, Erfle, Holger, Thiel, Volker, Lohmann, Volker, Superti-Furga, Giulio, Brügger, Britta, Bartenschlager, Ralf

“…Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are…”
Get full text

No Evidence for Human Monocyte-Derived Macrophage Infection and Antibody-Mediated Enhancement of SARS-CoV-2 Infection by García-Nicolás, Obdulio, V'kovski, Philip, Zettl, Ferdinand, Zimmer, Gert, Thiel, Volker, Summerfield, Artur

“…Vaccines are essential to control the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and to protect the vulnerable population. However,…”
Get full text

LY6E impairs coronavirus fusion and confers immune control of viral disease by Pfaender, Stephanie, Mar, Katrina B., Michailidis, Eleftherios, Kratzel, Annika, Boys, Ian N., V’kovski, Philip, Fan, Wenchun, Kelly, Jenna N., Hirt, Dagny, Ebert, Nadine, Stalder, Hanspeter, Kleine-Weber, Hannah, Hoffmann, Markus, Hoffmann, Hans-Heinrich, Saeed, Mohsan, Dijkman, Ronald, Steinmann, Eike, Wight-Carter, Mary, McDougal, Matthew B., Hanners, Natasha W., Pöhlmann, Stefan, Gallagher, Tom, Todt, Daniel, Zimmer, Gert, Rice, Charles M., Schoggins, John W., Thiel, Volker

“…Zoonotic coronaviruses (CoVs) are substantial threats to global health, as exemplified by the emergence of two severe acute respiratory syndrome CoVs (SARS-CoV…”
Get full text

Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2 by Gultom, Mitra, Licheri, Matthias, Laloli, Laura, Wider, Manon, Strassle, Marina, Vkovski, Philip, Steiner, Silvio, Kratzel, Annika, Thao, Tran Thi Nhu, Probst, Lukas, Stalder, Hanspeter, Portmann, Jasmine, Holwerda, Melle, Ebert, Nadine, Stokar-Regenscheit, Nadine, Gurtner, Corinne, Zanolari, Patrik, Posthaus, Horst, Schuller, Simone, Vicente-Santos, Amanda, Moreira-Soto, Andres, Corrales-Aguilar, Eugenia, Ruggli, Nicolas, Tekes, Gergely, von Messling, Veronika, Sawatsky, Bevan, Thiel, Volker, Dijkman, Ronald

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, and the number of worldwide cases continues to rise. The zoonotic origins of…”
Get full text

Rapid Quantification of SARS-CoV-2-Neutralizing Antibodies Using Propagation-Defective Vesicular Stomatitis Virus Pseudotypes by Zettl, Ferdinand, Meister, Toni Luise, Vollmer, Tanja, Fischer, Bastian, Steinmann, Jörg, Krawczyk, Adalbert, V’kovski, Philip, Todt, Daniel, Steinmann, Eike, Pfaender, Stephanie, Zimmer, Gert

“…Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2, a new member of the genus Betacoronavirus, is a pandemic virus, which has caused numerous…”
Get full text

Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis by Kelly, Jenna N., Laloli, Laura, V’kovski, Philip, Holwerda, Melle, Portmann, Jasmine, Thiel, Volker, Dijkman, Ronald

“…The respiratory epithelium constitutes the first line of defense against invading respiratory pathogens, such as the 2009 pandemic strain of influenza A virus…”
Get full text

Generation and Characterization of an Influenza D Reporter Virus by Probst, Lukas, Laloli, Laura, Licheri, Manon Flore, Licheri, Matthias, Gultom, Mitra, Holwerda, Melle, V'kovski, Philip, Dijkman, Ronald

“…Influenza D virus (IDV) can infect various livestock animals, such as cattle, swine, and small ruminants, and was shown to have zoonotic potential. Therefore,…”
Get full text

Time-resolved characterization of the innate immune response in the respiratory epithelium of human, porcine, and bovine during influenza virus infection by Laloli, Laura, Licheri, Manon Flore, Probst, Lukas, Licheri, Matthias, Gultom, Mitra, Holwerda, Melle, V’kovski, Philip, Dijkman, Ronald

“…Viral cross-species transmission is recognized to be a major threat to both human and animal health, however detailed information on determinants underlying…”
Get full text

Identification of an Antiviral Compound from the Pandemic Response Box that Efficiently Inhibits SARS-CoV-2 Infection In Vitro by Holwerda, Melle, V'kovski, Philip, Wider, Manon, Thiel, Volker, Dijkman, Ronald

“…With over 50 million currently confirmed cases worldwide, including more than 1.3 million deaths, the severe acute respiratory syndrome coronavirus 2…”
Get full text