Search Results - "Vizioli, Maria"
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Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex
Published in Nature communications (10-07-2015)“…Histone chaperones bind specific histones to mediate their storage, eviction or deposition from/or into chromatin. The HIRA histone chaperone complex, composed…”
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2
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Published in Nature (London) (19-10-2017)“…Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated…”
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3
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Published in Genes & development (01-03-2020)“…Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable…”
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4
Cytoplasmic chromatin fragments-from mechanisms to therapeutic potential
Published in eLife (29-01-2021)“…Senescent cells, damaged cells that permanently exit the cell cycle, play important roles in development, tissue homeostasis, and tumorigenesis. Although many…”
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Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism
Published in Journal of experimental & clinical cancer research (21-05-2019)“…Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and…”
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6
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
Published in Genes & development (15-12-2014)“…Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of…”
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7
Role of STAT3 in in vitro transformation triggered by TRK oncogenes
Published in PloS one (03-03-2010)“…TRK oncoproteins are chimeric versions of the NTRK1/NGF receptor and display constitutive tyrosine kinase activity leading to transformation of NIH3T3 cells…”
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8
S100A11 Overexpression Contributes to the Malignant Phenotype of Papillary Thyroid Carcinoma
Published in The journal of clinical endocrinology and metabolism (01-10-2013)“…Context: Papillary thyroid carcinoma (PTC) is the most frequent thyroid tumor and is responsible for the overall increase in thyroid cancer incidence. S100A11…”
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9
Evidence of oncogene-induced senescence in thyroid carcinogenesis
Published in Endocrine-related cancer (01-12-2011)“…Oncogene-induced senescence (OIS) is a growth arrest triggered by the enforced expression of cancer-promoting genes and acts as a barrier against malignant…”
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Apoptotic stress causes mtDNA release during senescence and drives the SASP
Published in Nature (London) (19-10-2023)“…Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP) 1 …”
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11
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
Published in The EMBO journal (03-05-2021)“…Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐inflammatory phenotype, thought to contribute to aging and…”
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Correction: Oncogenic RAS -induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved
Published in Oncotarget (14-10-2022)Get full text
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13
Senescence Can Be BETter without the SASP?
Published in Cancer discovery (01-06-2016)“…Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and…”
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14
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP
Published in Nature (London) (18-01-2024)Get full text
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15
Sociodemographic, clinical and organisational factors associated with delayed hospital discharges: a cross-sectional study
Published in BMC health services research (15-03-2014)“…Evidence from studies conducted in Western countries indicates that a significant proportion of hospital beds are occupied by patients who experience a delayed…”
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16
Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved
Published in Oncotarget (30-09-2014)“…Oncogene-induced senescence (OIS) is a robust and sustained antiproliferative response to oncogenic stress and constitutes an efficient barrier to tumour…”
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17
The Italian National Rare Diseases Registry: a model of comparison and integration with Hospital Discharge Data
Published in Journal of public health (Oxford, England) (01-03-2019)“…Italy has been the first country at European level to implement a population-based public health registry dedicated to rare diseases. This study describes the…”
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18
The Italian National Rare Diseases Registry
Published in Blood transfusion = Trasfusione del sangue (01-04-2014)“…Rare disease registries are a priority at European level and specific actions are being implemented by the European Commission to support their development.In…”
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19
Increasing appropriateness of hospital admissions in the Emilia-Romagna region of Italy
Published in Journal of health services research & policy (01-10-2008)“…The Emilia-Romagna region of Italy has reduced the number of available hospital beds and introduced financial incentives to curb hospital use. The goal of this…”
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20
Role of Oncogene-Induced Senescence in Thyroid Carcinogenesis
Published 01-01-2012“…Oncogene-induced senescence (OIS) is an irreversible G1 cell cycle arrest triggered by aberrant expression of oncogenes. The arrest observed during senescence…”
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