Search Results - "Vivian, Randall W."

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function by Hebner, Christy M, Han, Bin, Brendza, Katherine M, Nash, Michelle, Sulfab, Maisoun, Tian, Yang, Hung, Magdeleine, Fung, Wanchi, Vivian, Randall W, Trenkle, James, Taylor, James, Bjornson, Kyla, Bondy, Steven, Liu, Xiaohong, Link, John, Neyts, Johan, Sakowicz, Roman, Zhong, Weidong, Tang, Hengli, Schmitz, Uli

“…Tegobuvir (TGV) is a novel non-nucleoside inhibitor (NNI) of HCV RNA replication with demonstrated antiviral activity in patients with genotype 1 chronic HCV…”
Get full text

Copper Hydride- Catalyzed Tandem 1,4-Reduction/Alkylation Reactions by Lipshutz, Bruce H., Chrisman, Will, Noson, Kevin, Papa, Patrick, Sclafani, Joseph A., Vivian, Randall W., Keith, John M.

“…Exposure of an enone to a catalytic quantity of [CuH(PPh 3)] 6 in the presence of one of several silyl hydrides (PhMe 2SiH, PMHS, HMe 2SiOSiMe 2H) leads to…”
Get full text

Reductions of aryl perfluorosulfonates with dimethylamine · borane (Me 2NH·BH 3) catalyzed by Pd(0): an operationally simple, inexpensive, and general protocol by Lipshutz, Bruce H., Buzard, D.J., Vivian, Randall W.

“…Treatment of aryl nonaflates or triflates in CH 3CN in the presence of one equivalent of Me 2NH·BH 3 and K 2CO 3 leads via Pd(0) catalysis to high yields of…”
Get full text

Cu(I)- catalyzed substitution reactions of activated vinyl triflates with functionalized organozinc reagents by Lipshutz, Bruce H., Vivian, Randall W.

“…Treatment of a mixed, functionalized dialkylzinc species with catalytic amounts of CuCN·2LiCl produces a reagent which readily displaces an activated vinyl…”
Get full text