Search Results - "Vivian, Jeffrey"

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque by Uslaner, Jason M., Eddins, Donnie, Puri, Vanita, Cannon, Christopher E., Sutcliffe, Jane, Chew, Chan Sing, Pearson, Michelle, Vivian, Jeffrey A., Chang, Ronald K., Ray, William J., Kuduk, Scott D., Wittmann, Marion

“…Rationale The current standards of care for Alzheimer’s disease, acetylcholinesterase inhibitors, have limited efficacy due to a host of mechanism-related side…”
Get full text

The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey by Eddins, Donnie, Hamill, Terence G., Puri, Vanita, Cannon, Christopher E., Vivian, Jeffrey A., Sanabria-Bohórquez, Sandra M., Cook, Jacquelynn J., Morrow, John A., Thomson, Fiona, Uslaner, Jason M.

“…Reduced NMDA receptor functioning is hypothesized to underlie the cognitive and negative symptoms associated with schizophrenia. However, because direct…”
Get full text

The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys by Cannon, Christopher E., Puri, Vanita, Vivian, Jeffrey A., Egbertson, Melissa S., Eddins, Donnie, Uslaner, Jason M.

“…The cognitive deficits associated with schizophrenia are recognized as a core component of the disorder, yet there remain no available therapeutics to treat…”
Get full text

Characterization of the discriminative stimulus effects of N-methyl-D-aspartate ligands under different ethanol training conditions in the cynomolgus monkey (Macaca fascicularis) by VIVIAN, Jeffrey A, WATERS, Courtney A, SZELIGA, Kendall T, JORDAN, Kristen, GRANT, Kathleen A

“…The current study was designed to extend our knowledge of the N-methyl- D-aspartate (NMDA) glutamate receptor system in mediating the discriminative stimulus…”
Get full text

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors by Ballard, Theresa M., Knoflach, Frédéric, Prinssen, Eric, Borroni, Edilio, Vivian, Jeffrey A., Basile, Jennifer, Gasser, Rodolfo, Moreau, Jean-Luc, Wettstein, Joseph G., Buettelmann, Bernd, Knust, Henner, Thomas, Andrew W., Trube, Gerhard, Hernandez, Maria-Clemencia

Get full text

Discriminative Stimulus Effects of Ethanol in Mice Lacking the γ-Aminobutyric Acid Type A Receptor δ Subunit by Shannon, Erin E., Shelton, Keith L., Vivian, Jeffrey A., Yount, Ingrid, Morgan, Ashley R., Homanics, Gregg E., Grant, Kathleen A.

“…Background: Genetically altered mice have been used to examine gene contributions to ethanol phenotypes. Recently, mice with a targeted deletion of the δ…”
Get full text

Klaus A. Miczek (1945–2024) by Weerts, Elise M., Haney, Margaret, Tidey, Jennifer W., Vivian, Jeffrey A.

Get full text

Thyromimetics improve disease endpoints and modulate potential target engagement biomarkers in rodent models of ALD and MS (P3-4.011) by Woerner, Michaelanne, Vivian, Jeffrey, Alavi, Aryan, Klova, Amy, Hellerstein, Marc, Gandhi, Rohan, Beals, Chan, Stearns, Brian, MacKenna, Deidre

“…Abstract only…”
Get full text

Interactions between social stress and morphine in the periaqueductal gray : effects on affective vocal and reflexive pain responses in rats by VIVIAN, J. A, MICZEK, K. A

“…Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive,…”
Get full text

Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: antagonist effects of SR 141716A by Vivian, J A, Kishioka, S, Butelman, E R, Broadbear, J, Lee, K O, Woods, J H

“…This study characterized the antinociceptive, respiratory and heart rate effects of the cannabinoid receptor agonists Delta-9-tetrahydrocannabinol…”
Get more information

Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat by Gu, Guibao, Scott, Trevor, Yan, Yingzhuo, Warren, Noelle, Zhang, Adia, Tabatabaei, Ali, Xu, Hao, Aertgeerts, Kathleen, Gomez, Laurent, Morse, Andrew, Li, Yu-Wen, Breitenbucher, J Guy, Massari, Eben, Vivian, Jeffrey, Danks, Anne

“…Inhibition of phosphodiesterase 2A (PDE2A) has been proposed as a potential approach to enhance cognitive functioning and memory through boosting intracellular…”
Get more information

Rapid identification of a novel phosphodiesterase 7B tracer for receptor occupancy studies using LC─MS/MS by Chen, Jie, Gu, Guibao, Chen, Mi, Scott, Trevor, Heger, Lindsay, Zook, Douglas, Chung, DeMichael, Keenan, Terence, Renick, Joel, Santora, Vincent J., Vivian, Jeffrey, Stauber, Kathe, Breitenbucher, James Guy, Tabatabaei, Ali

“…Phosphodiesterase 7B (PDE7B) inhibition has been considered as a therapeutic target for the treatment of several neurological disorders. Currently, there are…”
Get full text

Opicapone improves the effects of L‐DOPA on the MPTP‐induced Parkinson's‐like syndrome in cynomolgus monkeys by Bonifacio, Maria Joao, Medakkar, Sonali, Sousa, Filipa, Vivian, Jeffrey A, Soares‐da‐Silva, Patricio

“…Abstract only…”
Get full text

Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys by BUTELMAN, E. R, VIVIAN, J. A, JIM YU, KREEK, M.-J, WOODS, J. H

“…E-2078 ([N-methyl-Tyr1, N-methyl-Arg7, D-Leu8] dynorphin A(1-8) ethylamide) is a dynorphin A(1-8) analog with a reduced tendency to be biotransformed, when…”
Get full text

Opicapone improved the effect of L-DOPA on the MPTP-induced Parkinson's-like syndrome in cynomolgus monkeys by Bonifacio, Maria Joao, Sousa, Filipa, Medakkar, Sonali, Vivian, Jeffrey, Soares-da-Silva, Patrício

Get full text

Bioavailable pyrrolo-benzo-1,4-diazines as Nav1.7 sodium channel blockers for the treatment of pain by Yang, Shu-Wei, Ho, Ginny D., Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Sun, Xianfeng, Sakwa, Samuel A., Herr, R. Jason, Zhou, Xiaoping, Bridal, Terry, Urban, Mark, Vivian, Jeffrey, Rindgen, Diane, Sorota, Steve

“…A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate selectivity over Nav1.5…”
Get full text

Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain by Yang, Shu-Wei, Ho, Ginny D, Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Sun, Xianfeng, Sakwa, Samuel A, Herr, R Jason, Zhou, Xiaoping, Bridal, Terry, Urban, Mark, Vivian, Jeffrey, Rindgen, Diane, Sorota, Steve

“…A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized to improve the profile of the previous lead compound 1. The syntheses, structure-activity…”
Get full text

Diazepam withdrawal : effects of diazepam and gepirone on acoustic startle-induced 22 kHz ultrasonic vocalizations by VIVIAN, J. A, FARRELL, W. J, SAPPERSTEIN, S. B, MICZEK, K. A

“…It has proven difficult to demonstrate and study the "anxiogenic" quality of drug withdrawal states in animals. Ultrasonic vocalizations (USV) in response to…”
Get full text

Bioavailable pyrrolo-benzo-1,4-diazines as Na sub(v)1.7 sodium channel blockers for the treatment of pain by Yang, Shu-Wei, Ho, Ginny D, Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Sun, Xianfeng, Sakwa, Samuel A, Herr, RJason, Zhou, Xiaoping, Bridal, Terry, Urban, Mark, Vivian, Jeffrey, Rindgen, Diane, Sorota, Steve

“…A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized to improve the profile of the previous lead compound 1. The syntheses, structure-activity…”
Get full text

Cognition‐enhancing effects of nicotine, GTS‐21, donepezil and memantine on object retrieval in cynomolgus monkeys by Vivian, Jeffrey Alan, Basile, Jennifer Lee

“…The development and validation of tests of executive function are of paramount importance to preclinical efforts in cognition. Object retrieval assesses…”
Get full text