Search Results - "Vivekanandan, Varunika"
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REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors
Published in Genes & development (01-06-2020)“…Human cancers with activating mutations are typically highly aggressive and treatment-refractory, yet mutation itself is insufficient for tumorigenesis, due in…”
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Journal Article -
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Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
Published in Science advances (01-01-2020)“…Women harboring heterozygous germline mutations of have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly…”
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Journal Article -
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MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Published in Translational cancer research (01-12-2016)“…The tumor suppressor p53 plays a central role in safeguarding cellular homeostasis. Upon various types of stress signals such as DNA damage or oncogenic…”
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Journal Article