Search Results - "Viveca Giongo"
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Antiviral Potential of Naphthoquinones Derivatives Encapsulated within Liposomes
Published in Molecules (Basel, Switzerland) (25-10-2021)“…HSV infections, both type 1 and type 2, are among the most widespread viral diseases affecting people of all ages. Their symptoms could be mild, with cold…”
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Chloroquinolone Carboxamide Derivatives as New Anti-HSV-1 Promising Drugs
Published in Current topics in medicinal chemistry (01-01-2023)“…Since the emergence of HSV resistant strains, new antiviral agents have emerged and still are urgently needed, especially those with alternative targets. In…”
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Aminomethylnaphthoquinones and HSV-1: in vitro and in silico evaluations of potential antivirals
Published in Antiviral therapy (01-01-2016)“…Herpes simplex viruses (HSV) are leading causes of human infections which result in severe manifestations, especially in neonates, immunocompromised and/or…”
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Docking of anti-HIV-1 oxoquinoline-acylhydrazone derivatives as potential HSV-1 DNA polymerase inhibitors
Published in Journal of molecular structure (25-09-2014)“…In this work, we use molecular modeling simulations, such as molecular docking, in order to rationalize structural modifications which should increase the…”
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SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series
Published in Bioorganic & medicinal chemistry (2008)“…Herpes Simplex Virus (HSV) infections are among the most common human diseases. In this work, we assess the structural features and electronic properties of a…”
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Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1
Published in Bioorganic & medicinal chemistry letters (01-08-2012)“…In this work we report the synthesis and in vitro anti-HIV-1 evaluation of a new class of oxoquinoline acyclonucleoside phosphonate analogues ethyl…”
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Anti-herpetic activities of chemical components from the Brazilian red alga Plocamium brasiliense
Published in Natural product communications (01-08-2010)“…The CH2Cl2 crude extract and a fraction enriched with halogenated monoterpenes of the Brazilian red alga Plocamium brasiliense were evaluated for cytotoxicity…”
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Effects of hydrostatic pressure on the Leptospira interrogans: high immunogenicity of the pressure-inactivated serovar hardjo
Published in Vaccine (08-01-2001)“…The Hardjoprajitno strain of Leptospira interrogans serovar hardjo was subjected to different hydrostatic pressures. Complete inactivation occurred when the…”
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Subchronic toxicity and anti-HSV-1 activity in experimental animal of dolabelladienetriol from the seaweed, Dictyota pfaffii
Published in Regulatory toxicology and pharmacology (01-06-2017)“…This study examined in rats the subchronic toxicity and anti- HSV-1activity after oral administration of dolabelladienetriol (D1), a diterpene isolated from…”
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Anti-HIV-1 activity of compounds derived from marine alga Canistrocarpus cervicornis
Published in Journal of applied phycology (01-08-2016)“…This paper describes the inhibition of human immunodeficiency virus-type 1 (HIV-1) virus replication in tumor cell lines by marine dolastanes (1–3) and…”
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Caulerpin as a potential antiviral drug against herpes simplex virus type 1
Published in Revista brasileira de farmacognosia (01-08-2012)“…About 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir,…”
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Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives
Published in Bioorganic & medicinal chemistry (01-08-2009)“…In the present article, we describe the synthesis, anti-HIV1 profile and molecular modeling evaluation of 11 oxoquinoline derivatives. In the present article,…”
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Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
Published in Revista brasileira de farmacognosia (01-08-2012)“…Bovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the…”
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Molecular Modeling of a Phenyl-Amidine Class of NMDA Receptor Antagonists and the Rational Design of New Triazolyl-Amidine Derivatives
Published in Chemical biology & drug design (01-02-2013)“…Recently, many efforts have been made to develop N‐methyl‐d‐aspartic acid receptor antagonists for treating different pathological conditions such as…”
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Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
Published in Revista brasileira de farmacognosia (01-04-2011)“…Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low…”
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SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3 H-benzo[ b]pyrazolo[3,4- h]-1,6-naphthyridine series
Published in Bioorganic & medicinal chemistry (2008)“…Herein we applied rigid analogue and isosteric replacement approaches to design and synthesize nine new 3 H-benzo[ b]pyrazolo[3,4- h]-1,6-naphthyridine…”
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Pressure-induced formation of inactive triple-shelled rotavirus particles is associated with changes in the spike protein VP4
Published in Journal of molecular biology (13-04-2001)“…Rotaviruses are non-enveloped, triple-shelled particles that cause enteritis in animals and humans. The interactions among the different viral proteins located…”
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Potential antiviral activity of Plexaurella regia on the replication of herpes simplex virus type 1
Published in DST (01-04-2022)“…Introduction: Latency and resistance of acyclovir-resistant strains of Herpes simplex virus type 1 (HSV-1) have been associated with serious sequelae in…”
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