Search Results - "Vivas‐Mejia, Pablo"

Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes by Díaz, Mónica Rivera, Vivas-Mejia, Pablo E

“…Nanomedicine is a growing research field dealing with the creation and manipulation of materials at a nanometer scale for the better treatment, diagnosis and…”
Get full text

Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells by Rabelo-Fernández, Robert J, Noriega Rivera, Ricardo A, Rivera, Yasmarie Santana, Tous-Beveraggi, José, Valiyeva, Fatima, Vivas-Mejia, Pablo E

“…RNA-Binding Protein with Multiple Splicing (RBPMS) is a member of family proteins that bind to nascent RNA transcripts and regulate their splicing,…”
Get full text

MicroRNA‐1307‐3p contributes to breast cancer progression through PRM2 by Estupiñan‐Jiménez, José Roberto, Villarreal‐García, Valeria, Gonzalez‐Villasana, Vianey, Vivas‐Mejia, Pablo E., Vazquez‐Guillen, Jose Manuel, Zapata‐Morin, Patricio Adrián, Flores‐Colón, Marienid, Altamirano‐Torres, Claudia, Viveros‐Valdez, Ezequiel, Ivan, Cristina, Rashed, Mohammed H., Bayraktar, Recep, Rodríguez‐Padilla, Cristina, Lopez‐Berestein, Gabriel, Resendez‐Perez, Diana

“…Background Despite advances in screening and therapy, breast cancer (BC) remains the predominant cancer in women globally. Dysregulation of microRNAs (miRNAs)…”
Get full text

Targeting MicroRNA-143 Leads to Inhibition of Glioblastoma Tumor Progression by Lozada-Delgado, Eunice L, Grafals-Ruiz, Nilmary, Miranda-Román, Miguel A, Santana-Rivera, Yasmarie, Valiyeva, Fatma, Rivera-Díaz, Mónica, Marcos-Martínez, María J, Vivas-Mejía, Pablo E

“…Glioblastoma (GBM) is the most common and aggressive of all brain tumors, with a median survival of only 14 months after initial diagnosis. Novel therapeutic…”
Get full text

Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles by TANAKA, Takemi, MANGALA, Lingegowda S, JIANHUA GU, FAKHOURY, Jean R, CHIAPPINI, Ciro, CHUNHUA LU, MATSUO, Koji, GODIN, Biana, STONE, Rebecca L, NICK, Alpa M, LOPEZ-BERESTEIN, Gabriel, SOOD, Anil K, VIVAS-MEJIA, Pablo E, FERRARI, Mauro, NIEVES-ALICEA, René, MANN, Aman P, MORA, Edna, HAN, Hee-Dong, SHAHZAD, Mian M. K, XUEWU LIU, BHAVANE, Rohan

“…RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has…”
Get full text

Downstream Effectors of ILK in Cisplatin-Resistant Ovarian Cancer by Reyes-González, Jeyshka M, Quiñones-Díaz, Blanca I, Santana, Yasmarie, Báez-Vega, Perla M, Soto, Daniel, Valiyeva, Fatima, Marcos-Martínez, María J, Fernández-de Thomas, Ricardo J, Vivas-Mejía, Pablo E

“…Despite good responses to first-line treatment with platinum-based combination chemotherapy, most ovarian cancer patients will relapse and eventually develop…”
Get full text

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis by Sood, Anil K, Armaiz-Pena, Guillermo N, Halder, Jyotsnabaran, Nick, Alpa M, Stone, Rebecca L, Hu, Wei, Carroll, Amy R, Spannuth, Whitney A, Deavers, Michael T, Allen, Julie K, Han, Liz Y, Kamat, Aparna A, Shahzad, Mian M K, McIntyre, Bradley W, Diaz-Montero, Claudia M, Jennings, Nicholas B, Lin, Yvonne G, Merritt, William M, DeGeest, Koen, Vivas-Mejia, Pablo E, Lopez-Berestein, Gabriel, Schaller, Michael D, Cole, Steven W, Lutgendorf, Susan K

“…Chronic stress is associated with hormonal changes that are known to affect multiple systems, including the immune and endocrine systems, but the effects of…”
Get full text

96 Unlocking the Potential of Simalikalactone D as an Anticancer Agent in Ethnically Diverse Breast Cancer Populations by Sanchez-Alvarez, Annelis O., Vivas-Mejia, Pablo E., Ospina, Claudia

“…OBJECTIVES/GOALS: This project focuses on investigating the potential of Simalikalactone D (SKD) as an anticancer agent, exploring the mechanisms underlying…”
Get full text

Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier by Sharma, Rohit K, Calderon, Carlos, Vivas-Mejia, Pablo E

“…Glioblastoma (GBM) is the most malignant form of all primary brain tumors, and it is responsible for around 200,000 deaths each year worldwide. The standard…”
Get full text

Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors by Gaur, Puja, Sceusi, Eric L, Samuel, Shaija, Xia, Ling, Fan, Fan, Zhou, Yunfei, Lu, Jia, Tozzi, Federico, Lopez–Berestein, Gabriel, Vivas–Mejia, Pablo, Rashid, Asif, Fleming, Jason B, Abdalla, Eddie K, Curley, Steven A, Vauthey, Jean–Nicolas, Sood, Anil K, Yao, James C, Ellis, Lee M

“…Background & Aims Metastatic gastrointestinal neuroendocrine tumors (NETs) frequently are refractory to chemotherapy. Chemoresistance in various malignancies…”
Get full text

MicroRNA-92b targets tumor suppressor gene FBXW7 in glioblastoma by Grafals-Ruiz, Nilmary, Sánchez-Álvarez, Annelis O, Santana-Rivera, Yasmarie, Lozada-Delgado, Eunice L, Rabelo-Fernandez, Robert J, Rios-Vicil, Christian I, Valiyeva, Fatima, Vivas-Mejia, Pablo E

“…Glioblastoma (GBM) is a highly aggressive and lethal primary brain tumor. Despite limited treatment options, the overall survival of GBM patients has shown…”
Get full text

Effect of Cyclodextrins Formulated in Liposomes and Gold and Selenium Nanoparticles on siRNA Stability in Cell Culture Medium by Castillo Cruz, Betzaida, Chinapen Barletta, Sandra, Ortiz Muñoz, Bryan G, Benitez-Reyes, Adriana S, Amalbert Perez, Omar A, Cardona Amador, Alexander C, Vivas-Mejia, Pablo E, Barletta, Gabriel L

“…Encapsulation of siRNA fragments inside liposome vesicles has emerged as an effective method for delivering siRNAs in vitro and in vivo. However, the…”
Get full text

Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells by Rabelo-Fernández, Robert J, Santiago-Sánchez, Ginette S, Sharma, Rohit K, Roche-Lima, Abiel, Carrion, Kelvin Carrasquillo, Rivera, Ricardo A Noriega, Quiñones-Díaz, Blanca I, Rajasekaran, Swetha, Siddiqui, Jalal, Miles, Wayne, Rivera, Yasmarie Santana, Valiyeva, Fatima, Vivas-Mejia, Pablo E

“…Worldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For…”
Get full text

Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer by VIVAS-MEJIA, Pablo E, RODRIGUEZ-AGUAYO, Cristian, HAN, Hee-Dong, SHAHZAD, Mian M. K, VALIYEVA, Fatma, SHIBAYAMA, Mineko, CHAVEZ-REYES, Arturo, SOOD, Anil K, LOPEZ-BERESTEIN, Gabriel

“…To study the role of survivin and its splice variants in taxane-resistant ovarian cancer. We assessed the mRNA levels of survivin splice variants in ovarian…”
Get full text

Therapeutic Targeting of ATP7B in Ovarian Carcinoma by MANGALA, Lingegowda S, ZUZEL, Vesna, NICK, Alpa M, DANES, Christopher G, LEE, Jeong-Won, JENNINGS, Nicholas B, VIVAS-MEJIA, Pablo E, WOLF, Judith K, COLEMAN, Robert L, SIDDIK, Zahid H, LOPEZ-BERESTEIN, Gabriel, LUTSENKO, Svetlana, SCHMANDT, Rosemarie, SOON, Anil K, LESHANE, Erik S, HALDER, Jyotsna B, ARMAIZ-PENA, Guillermo N, SPANNUTH, Whitney A, TANAKA, Takemi, SHAHZAD, Mian M. K, LIN, Yvonne G

“…Purpose: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic…”
Get full text

A Fresh Look at the Potential of Cyclodextrins for Improving the Delivery of siRNA Encapsulated in Liposome Nanocarriers by Castillo Cruz, Betzaida, Flores Colón, Marienid, Rabelo Fernandez, Robert J, Vivas-Mejia, Pablo E, Barletta, Gabriel L

“…Liposomes are among the most effective vehicles to deliver siRNAs to cells, both in vitro and in vivo. However, despite numerous efforts to improve the…”
Get full text

MicroRNA-27a distinguishes glioblastoma multiforme from diffuse and anaplastic astrocytomas and has prognostic value by Rivera-Díaz, Mónica, Miranda-Román, Miguel A, Soto, Daniel, Quintero-Aguilo, Mario, Ortiz-Zuazaga, Humberto, Marcos-Martinez, María J, Vivas-Mejía, Pablo E

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs that bind to 3'-untranslated (UTR) regions of target messenger RNAs to regulate protein synthesis…”
Get full text

Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer by Santiago-Sánchez, Ginette S, Pita-Grisanti, Valentina, Quiñones-Díaz, Blanca, Gumpper, Kristyn, Cruz-Monserrate, Zobeida, Vivas-Mejía, Pablo E

“…Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including transporting hydrophobic ligands across cell membranes,…”
Get full text

Clinical and biological significance of tissue transglutaminase in ovarian carcinoma by Hwang, Jee Young, Mangala, Lingegowda S, Fok, Jansina Y, Lin, Yvonne G, Merritt, William M, Spannuth, Whitney A, Nick, Alpa M, Fiterman, Derek J, Vivas-Mejia, Pablo E, Deavers, Michael T, Coleman, Robert L, Lopez-Berestein, Gabriel, Mehta, Kapil, Sood, Anil K

“…Tissue type transglutaminase (TG2) is a unique multifunctional protein that plays a role in many steps in the cancer metastatic cascade. Here, we examined the…”
Get full text

Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway by Echevarría-Vargas, Ileabett M, Valiyeva, Fatma, Vivas-Mejía, Pablo E

“…Cisplatin has been the most accepted drug for the treatment of ovarian cancer for almost 40 years. Although the majority of patients with ovarian cancer…”
Get full text