Search Results - "Vitelli, Salvatore"

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody by Glantschnig, Helmut, Scott, Kevin, Hampton, Richard, Wei, Nan, McCracken, Paul, Nantermet, Pascale, Zhao, Jing Z, Vitelli, Salvatore, Huang, Lingyi, Haytko, Peter, Lu, Ping, Fisher, John E, Sandhu, Punam, Cook, Jacquelynn, Williams, Donald, Strohl, William, Flores, Osvaldo, Kimmel, Donald, Wang, Fubao, An, Zhiqiang

“…Genetic studies have linked both osteoporotic and high bone mass phenotypes to low-density lipoprotein receptor-related proteins (LRP4, LRP5, and LRP6). LRPs…”
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Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains by Secore, Susan, Wang, Su, Doughtry, Julie, Xie, Jinfu, Miezeiewski, Matt, Rustandi, Richard R, Horton, Melanie, Xoconostle, Rachel, Wang, Bei, Lancaster, Catherine, Kristopeit, Adam, Wang, Sheng-Ching, Christanti, Sianny, Vitelli, Salvatore, Gentile, Marie-Pierre, Goerke, Aaron, Skinner, Julie, Strable, Erica, Thiriot, David S, Bodmer, Jean-Luc, Heinrichs, Jon H

“…Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the developed world. The main virulence factors of the bacterium are the…”
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IgG2m4, an engineered antibody isotype with reduced Fc function by An, Zhiqiang, Forrest, Gail, Moore, Renee, Cukan, Michael, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Zhao, Jing Zhang, Lu, Ping, Hua, Jin, Gibson, Christopher R., Harvey, Barrett R., Montgomery, Donna, Zaller, Dennis, Wang, Fubao, Strohl, William

“…The Fc region of an antibody mediates effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity…”
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Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge by CASIMIRO, Danilo R, COX, Kara, TOBERY, Timothy W, WILSON, Keith, FINNEFROCK, Adam, LINGYI HUANG, VITELLI, Salvatore, JING LIN, PATEL, Deepa, DAVIES, Mary-Ellen, HEIDECKER, Gwendolyn J, FREED, Daniel C, AIMIN TANG, DUBEY, Sheri, O'CONNOR, David H, WATKINS, David I, ZHANG, Zhi-Qiang, SHIVER, John W, SYKES, Kara J, MEIZHEN FENG, FUBAO WANG, BETT, Andrew, SCHLEIF, William A, XIAOPING LIANG, FLYNN, Jessica

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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S] by Ni, Yan G., Di Marco, Stefania, Condra, Jon H., Peterson, Laurence B., Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A., Rosa, Ray, Cummings, Richard T., Wood, Dana D., Liu, Xiaomei, Bottomley, Matthew J., Shen, Xun, Cubbon, Rose M., Wang, Sheng-ping, Johns, Douglas G., Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J., Sparrow, Carl P., Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

“…Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We…”
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Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41 by Montgomery, Donna L., Wang, Ying-Jie, Hrin, Renee, Luftig, Micah, Su, Bin, Miller, Michael D., Wang, Fubao, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Condra, Jon, Liu, Xiaomei, Hampton, Richard, Carfi, Andrea, Pessi, Antonello, Bianchi, Elisabetta, Joyce, Joseph, Lloyd, Chris, Geleziunas, Romas, Bramhill, David, King, Vicki M., Finnefrock, Adam C., Strohl, William, An, Zhiqiang

“…The human D5 monoclonal antibody binds to the highly conserved hydrophobic pocket on the N-terminal heptad repeat (NHR) trimer of HIV-1 gp41 and exhibits…”
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PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo by Ni, Yan G, Di Marco, Stefania, Condra, Jon H, Peterson, Laurence B, Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A, Rosa, Ray, Cummings, Richard T, Wood, Dana D, Liu, Xiaomei, Bottomley, Matthew J, Shen, Xun, Cubbon, Rose M, Wang, Sheng-ping, Johns, Douglas G, Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J, Sparrow, Carl P, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

“…Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We…”
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Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo by Glantschnig, Helmut, Hampton, Richard A., Lu, Ping, Zhao, Jing Z., Vitelli, Salvatore, Huang, Lingyi, Haytko, Peter, Cusick, Tara, Ireland, Cheryl, Jarantow, Stephen W., Ernst, Robin, Wei, Nan, Nantermet, Pascale, Scott, Kevin R., Fisher, John E., Talamo, Fabio, Orsatti, Laura, Reszka, Alfred A., Sandhu, Punam, Kimmel, Donald, Flores, Osvaldo, Strohl, William, An, Zhiqiang, Wang, Fubao

“…Wnt/LRP5 signaling is a central regulatory component of bone formative and resorptive activities, and the pathway inhibitor DKK1 is a suppressor of bone…”
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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors by Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E, Arnold, Beth A, Toner, Timothy J, Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T, Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frederic, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R, Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N, Franlin, Laura L, Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J, Audoly, Laurent P, Aster, Jon C, Blacklow, Stephen C, Huber, Hans E

“…Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other…”
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Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents by Chiu, Chi-Sung, Peekhaus, Norbert, Weber, Hans, Adamski, Sharon, Murray, Edward M, Zhang, Hai Zhuan, Zhao, Jing Zhang, Ernst, Robin, Lineberger, Janet, Huang, Lingyi, Hampton, Richard, Arnold, Beth Anne, Vitelli, Salvatore, Hamuro, Lora, Wang, Wei-Rong, Wei, Nan, Dillon, Greg M, Miao, Jiangyong, Alves, Stephen E, Glantschnig, Helmut, Wang, Fubao, Wilkinson, Hilary A

“…Myostatin is a highly conserved member of the transforming growth factor-β ligand family known to regulate muscle growth via activation of activin receptors. A…”
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Vaccine-Induced Cellular Responses Control Simian Immunodeficiency Virus Replication after Heterologous Challenge by WILSON, Nancy A, KEELE, Brandon F, CITRON, Michael P, LINGYI HUANG, JING LIN, VITELLI, Salvatore, AHN, Chanook D, KAIZU, Masahiko, MANESS, Nicholas J, REYNOLDS, Matthew R, FRIEDRICH, Thomas C, LOFFREDO, John T, REED, Jason S, RAKASZ, Eva G, ERICKSON, Stephen, ALLISON, David B, PIATAK, Michael, LIFSON, Jeffrey D, SHIVER, John W, CASIMIRO, Danilo R, SHAW, George M, HAHN, Beatrice H, WATKINS, David I, PIASKOWSKI, Shari M, MACNAIR, Caitlin E, BETT, Andrew J, XIAOPING LIANG, FUBAO WANG, THORYK, Elizabeth, HEIDECKER, Gwendolyn J

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Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A01-Negative Rhesus Monkeys by Liang, Xiaoping, Casimiro, Danilo R, Schleif, William A, Wang, Fubao, Davies, Mary-Ellen, Zhang, Zhi-Qiang, Fu, Tong-Ming, Finnefrock, Adam C, Handt, Larry, Citron, Michael P, Heidecker, Gwendolyn, Tang, Aimin, Chen, Minchun, Wilson, Keith A, Gabryelski, Lori, McElhaugh, Michael, Carella, Anthony, Moyer, Cheryl, Huang, Lingyi, Vitelli, Salvatore, Patel, Deepa, Lin, Jing, Emini, Emilio A, Shiver, John W

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Distinct expression profiles of Notch-1 protein in human solid tumors : implications for development of targeted therapeutic monoclonal antibodies by Li, Yuan

“…Reports the results of immunohistochemistry performed on tissue microarrays to determine whether the Notch-1 receptor is overexpressed in tumour cells as…”
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Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A 01-Negative Rhesus Monkeys by Liang, Xiaoping, Casimiro, Danilo R., Schleif, William A., Wang, Fubao, Davies, Mary-Ellen, Zhang, Zhi-Qiang, Fu, Tong-Ming, Finnefrock, Adam C., Handt, Larry, Citron, Michael P., Heidecker, Gwendolyn, Tang, Aimin, Chen, Minchun, Wilson, Keith A., Gabryelski, Lori, McElhaugh, Michael, Carella, Anthony, Moyer, Cheryl, Huang, Lingyi, Vitelli, Salvatore, Patel, Deepa, Lin, Jing, Emini, Emilio A., Shiver, John W.

“…ABSTRACT Simian-human immunodeficiency virus (SHIV) challenge studies in rhesus macaques were conducted to evaluate the efficacy of adenovirus-based vaccines…”
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Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A super()01-Negative Rhesus Monkeys by Liang, Xiaoping, Casimiro, Danilo R, Schleif, William A, Wang, Fubao, Davies, Mary-Ellen, Zhang, Zhi-Qiang, Fu, Tong-Ming, Finnefrock, Adam C, Handt, Larry, Citron, Michael P, Heidecker, Gwendolyn, Tang, Aimin, Chen, Minchun, Wilson, Keith A, Gabryelski, Lori, McElhaugh, Michael, Carella, Anthony, Moyer, Cheryl, Huang, Lingyi, Vitelli, Salvatore, Patel, Deepa, Lin, Jing, Emini, Emilio A, Shiver, John W

“…Simian-human immunodeficiency virus (SHIV) challenge studies in rhesus macaques were conducted to evaluate the efficacy of adenovirus-based vaccines in the…”
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