Search Results - "Vitek, M.P"

Microvascular injury and blood–brain barrier leakage in Alzheimer's disease by Zipser, B.D, Johanson, C.E, Gonzalez, L, Berzin, T.M, Tavares, R, Hulette, C.M, Vitek, M.P, Hovanesian, V, Stopa, E.G

“…Abstract Thinning and discontinuities within the vascular basement membrane (VBM) are associated with leakage of the plasma protein prothrombin across the…”
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Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease by Wilcock, D.M, Vitek, M.P, Colton, C.A

“…Abstract The neurovascular unit (NVU) comprises cerebral blood vessels and surrounding astrocytes, neurons, perivascular microglia and pericytes. Astrocytes…”
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Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease by Dawson, H.N, Cantillana, V, Jansen, M, Wang, H, Vitek, M.P, Wilcock, D.M, Lynch, J.R, Laskowitz, D.T

“…Abstract A central issue in the pathogenesis of tauopathy is the question of how tau protein dysfunction leads to neurodegeneration. We have previously…”
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An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer’s disease pathology following closed head injury: Evidence of pharmacogenomic interaction by Wang, H, Durham, L, Dawson, H, Song, P, Warner, D.S, Sullivan, P.M, Vitek, M.P, Laskowitz, D.T

“…Abstract Apolipoprotein E (apoE) modifies glial activation and the CNS inflammatory response in an isoform-specific manner. Peptides derived from the…”
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Corrigendum to “an apolipoprotein e-based therapeutic improves outcome and reduces alzheimer’s disease pathology following closed head injury: Evidence of pharmacogenomic interaction” by Wang, H, Durham, L, Dawson, H, Song, P, Warner, D.S, Sullivan, P.M, Vitek, M.P, Laskowitz, D.T

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Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport by Colton, C.A., Czapiga, M., Snell-Callanan, J., Chernyshev, O.N., Vitek, M.P.

“…Previous studies have shown that apolipoprotein E (apoE) plays a role in immune function by modulating tissue redox balance. Using a mouse macrophage cell line…”
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Effect of FTY720 on the SET–PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity by Pippa, R, Dominguez, A, Christensen, D J, Moreno-Miralles, I, Blanco-Prieto, M J, Vitek, M P, Odero, M D

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APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics by Vitek, M P, Christensen, D J, Wilcock, D, Davis, J, Van Nostrand, W E, Li, F Q, Colton, C A

“…After age, the second largest risk factor for Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype, where APOE4 is associated with lower apoE protein…”
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Targeting SET/[I.sub.2]PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy by Switzer, C.H, Cheng, R.Y.S, Vitek, T.M, Christensen, D.J, Wink, D.A, Vitek, M.P

“…The SET oncoprotein participates in cancer progression by affecting multiple cellular processes, inhibiting the tumor suppressor protein phosphatase 2A (PP2A),…”
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Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity by Switzer, C H, Ridnour, L A, Cheng, R Y S, Sparatore, A, Del Soldato, P, Moody, T W, Vitek, M P, Roberts, D D, Wink, D A

“…The chemopreventative effects of dithiolethione compounds are attributed to their activation of antioxidant response elements (AREs) by reacting with the…”
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APOE genotype affects outcome in a murine model of sepsis : implications for a new treatment strategy by WANG, H, CHRISTENSEN, D. J, VITEK, M. P, SULLIVAN, P. M, LASKOWITZ, D. T

“…In this study, we assessed whether apolipoprotein E (APOE) polymorphism affects inflammatory responses and mortality in the caecal ligation and puncture model…”
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Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster by Latypova, E M, Timoshenko, S I, Kislik, G A, Vitek, M, Shvartsman, A L, Sarantseva, S V

“…The neuroprotective activity of apolipoprotein E (apoE) peptide mimetic Cog1410, containing amino acid sequence of the receptor-binding domain apoE, has been…”
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The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment by JACOBSEN, J. S, SPRUYT, M. A, BROWN, A. M, SAHASRABUDHE, S. R, BLUME, A. J, VITEK, M. P, MUENKEL, H. A, SONNENBERG-REINES, J

“…Amyloid precursor protein (APP) is cleaved predominantly within the beta amyloid peptide (BAP) domain to release a non-amyloidogenic amino-terminal PN2…”
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Expression of the Apolipoprotein E Gene Does Not Affect Motor Recovery After Sensorimotor Cortex Injury in the Mouse by Goldstein, L.B., Vitek, M.P., Dawson, H., Bullman, S.

“…Motor recovery after unilateral sensorimotor cortex ablation or sham-injury was measured in apolipoprotein E knockout and wild-type mice by testing their…”
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Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells by SAHASRABUDHE, S. R, SPRUYT, M. A, MUENKEL, H. A, BLUME, A. J, VITEK, M. P, JACOBSEN, J. S

“…Abnormal proteolytic processing of amyloid precursor protein (APP) is thought to be central to the formation and deposition of beta amyloid peptide in…”
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67 In-situ localization of S182 mRNA in sporadic Alzheimer's disease (AD) by Stopa, E.G., Vitek, M.P., Rubin, B.S., Schmechel, D., Kuo-Leblanc, V., Wei, Y., Song, P.C., King, J.C., Boteva, K., Mitsuda, N., Gilbert, J.R., Roses, A.D.

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Enzymatic generation of the amino terminus of the beta-amyloid peptide by SAHASRABUDHE, S. R, BROWN, A. M, HULMES, J. D, JACOBSEN, J. S, VITEK, M. P, BLUME, A. J, SONNENBERG, J. L

“…The major pathological change in Alzheimer's disease is the deposition of 39-42-amino acid beta-amyloid peptide (BAP) in the brain. Since BAP begins at the…”
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Transcript length heterogeneity at the small heat shock protein genes of Drosophila by Berger, E M, Vitek, M P, Morganelli, C M

“…Expression of the small heat shock protein (hsp) genes can be induced in cultured Drosophila cells by high temperature shock and by exposure to physiological…”
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Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone by Vitek, M P, Morganelli, C M, Berger, E M

“…When cultured Drosophila line S3 cells are incubated in the presence of the steroid hormone, ecdysterone, they flatten, elongate, and become motile. We show…”
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