The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results

Chronic spontaneous urticaria (CSU) is a distressing disease. We report real-world data from the global Chronic Urticaria Registry (CURE) about associations between various CSU states and sleep impairment, plus important health-related quality-of-life (HRQoL) outcomes and compared different methods...

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Published in:	The journal of allergy and clinical immunology in practice (Cambridge, MA) Vol. 11; no. 2; pp. 610 - 620.e5
Main Authors:	Kolkhir, Pavel, Laires, Pedro A., Salameh, Pascale, Asero, Riccardo, Bizjak, Mojca, Košnik, Mitja, Dissemond, Joachim, van Doorn, Martijn, Hawro, Tomasz, Kasperska-Zajac, Alicja, Zajac, Magdalena, Kocatürk, Emek, Peter, Jonny, Parisi, Claudio A.S., Ritchie, Carla A., Kulthanan, Kanokvalai, Tuchinda, Papapit, Fomina, Daria, Kovalkova, Elena, Khoshkhui, Maryam, Kouzegaran, Samaneh, Papapostolou, Niki, Du-Thanh, Aurélie, Kamegashira, Akiko, Meshkova, Raisa, Vitchuk, Alexander, Bauer, Andrea, Grattan, Clive, Staubach, Petra, Bouillet, Laurence, Giménez-Arnau, Ana M., Maurer, Marcus, Weller, Karsten
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-2023 Elsevier / American Academy of Allergy, Asthma & Immunology / American Academy of Allergy, Asthma and Immunology
Subjects:	Angioedema - chemically induced Anti-Allergic Agents - therapeutic use Chronic Disease Chronic spontaneous urticaria Chronic Urticaria - drug therapy Complete control/complete response to treatment CURE registry Human health and pathology Humans Life Sciences Male Omalizumab - therapeutic use Patient-reported outcomes Quality of life Urticaria - chemically induced Urticaria - drug therapy CC DLQI PhyGA CSU Complete control/complete response to treatment CURE registry UCT Chronic spontaneous urticaria IQR PRO sgAH Quality of life CR FU CU CU-Q2oL UAS7 HRQoL CURE GA Patient-reported outcomes ORa
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Summary:	Chronic spontaneous urticaria (CSU) is a distressing disease. We report real-world data from the global Chronic Urticaria Registry (CURE) about associations between various CSU states and sleep impairment, plus important health-related quality-of-life (HRQoL) outcomes and compared different methods to assess CSU states. CURE data were collected at baseline and 6-monthly follow-ups (FU). Assessments included CSU states using the Urticaria Control Test (UCT), weekly Urticaria Activity Score (UAS7), and Physician Global Assessment (PhyGA) of treatment response. Complete response to treatment (CR, UAS7 = 0), complete control of disease (CC, UCT = 16), and PhyGA = CR were assessed, plus the Dermatology Life Quality Index and the Chronic Urticaria Quality-of-Life Questionnaire (CU-Q2oL) sleep domain. Overall, 2078 patients were included. At baseline, 9.8%, 17.9%, and 42.3% of patients had UCT = 16, UAS7 = 0, or PhyGA = CR, respectively, which increased at FU1 and FU2. Patients with higher UCT scores had better sleep and HRQoL. The presence of angioedema without wheals, episodic disease, omalizumab treatment, and male sex were associated with CC (P < .05). Among 469 patients who achieved CC or CR, 16.4% (n = 77) showed CC or CR with all 3 instruments. Agreement between UCT = 16 and UAS7 = 0 measurements was moderate (κ = 0.581), but poor between UCT = 16 and PhyGA = CR (κ = 0.208). Few patients had CR/CC of their CSU at baseline entry. Disease control strongly related to good sleep and better HRQoL; therefore, it is important to aim for CR in CSU treatment. Patient-reported UCT and UAS7 assessments demonstrated a more accurate measurement of CSU state versus physician assessments.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2213-2198 2213-2201
DOI:	10.1016/j.jaip.2022.11.016