Search Results - "Vitaliti, Alessandra"

Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis by Vitaliti, Alessandra, De Luca, Anastasia, Rossi, Luisa

“…In recent years, copper function has been expanded beyond its consolidated role as a cofactor of enzyme catalysis. Recent papers have demonstrated a new…”
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Flow Cytometry Method Validation Protocols by Selliah, Nithianandan, Eck, Steven, Green, Cherie, Oldaker, Teri, Stewart, Jennifer, Vitaliti, Alessandra, Litwin, Virginia

“…Analytical method validation provides a means to ensure that data are credible and reproducible. This unit will provide a brief introduction to analytical…”
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SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult by Menduti, Giovanna, Vitaliti, Alessandra, Capo, Concetta Rosa, Lettieri-Barbato, Daniele, Aquilano, Katia, Malaspina, Patrizia, Rossi, Luisa

“…Succinate semialdehyde dehydrogenase (SSADH) is a mitochondrial enzyme, encoded by , mainly involved in γ-aminobutyric acid (GABA) catabolism and energy supply…”
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AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism by Vitaliti, Alessandra, Roccatani, Ilenia, Iorio, Egidio, Perta, Nunzio, Gismondi, Angelo, Chirico, Mattea, Pisanu, Maria Elena, Di Marino, Daniele, Canini, Antonella, De Luca, Anastasia, Rossi, Luisa

“…Background The main mechanism underlying cancer dissemination is the epithelial to mesenchymal transition (EMT). This process is orchestrated by cytokines like…”
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Long-Acting Octreotide and Prolonged-Release Lanreotide Formulations Have Different Pharmacokinetic Profiles by Astruc, Beatrice, Marbach, Peter, Bouterfa, Hakim, Denot, Caroline, Safari, Mitra, Vitaliti, Alessandra, Sheppard, Michael

“…Single‐dose pharmacokinetic (PK) profiles and multiple‐dose PK modeling were compared for long‐acting octreotide (20 or 60 mg) and prolonged‐release lanreotide…”
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Macrophages and autophagy: partners in crime by Vitaliti, Alessandra, Reggio, Alessio, Palma, Alessandro

“…Macrophages and autophagy are intricately linked, both playing vital roles in maintaining homeostasis and responding to disease. Macrophages, known for their…”
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Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials by Letzkus, Martin, Luesink, Evert, Starck-Schwertz, Sandrine, Bigaud, Marc, Mirza, Fareed, Hartmann, Nicole, Gerstmayer, Bernhard, Janssen, Uwe, Scherer, Andreas, Schumacher, Martin M, Verles, Aurelie, Vitaliti, Alessandra, Nirmala, Nanguneri, Johnson, Keith J, Staedtler, Frank

“…Background Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug…”
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Integration of single-cell datasets depicts profiles of macrophages and fibro/adipogenic progenitors in dystrophic muscle by Vitaliti, Alessandra, Reggio, Alessio, Colletti, Marta, Galardi, Angela, Palma, Alessandro

“…Single-cell technologies have recently expanded the possibilities for researchers to gain, at an unprecedented resolution level, knowledge about tissue…”
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High‐sensitivity flow cytometric assays: Considerations for design control and analytical validation for identification of Rare events by Sommer, Ulrike, Eck, Steven, Marszalek, Laura, Stewart, Jennifer J., Bradford, Jolene, McCloskey, Thomas W., Green, Cherie, Vitaliti, Alessandra, Oldaker, Teri, Litwin, Virginia

“…The current consensus recommendation papers dealing with the unique requirements for the analytical validation of assays performed by flow cytometry address…”
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P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion by Gotardo, Erica M.F., Torres, Lidiane S., Gushiken, Lucas F.S., Brito, Pamela L., Leonardo, Flavia C., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Vitaliti, Alessandra, Förster, Irmgard, Costa, Fernando Ferreira, Conran, Nicola

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Flow cytometric method transfer: Recommendations for best practice by Cabanski, Maciej, Oldaker, Teri, Stewart, Jennifer J., Selliah, Nithianandan, Eck, Steve, Green, Cherie, Litwin, Virginia, Vitaliti, Alessandra

“…As with many aspects of the validation and monitoring of flow cytometric methods, the method transfer processes and acceptance criteria described for other…”
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Flow Cytometry Method Validation Protocols by Selliah, Nithianandan, Nash, Veronica, Eck, Steven, Green, Cherie, Oldaker, Teri, Stewart, Jennifer, Vitaliti, Alessandra, Litwin, Virginia

“…Analytical method validation provides a means to ensure that data are credible and reproducible. This article will provide a brief introduction to analytical…”
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Possible alternative strategies to implement basophil activation testing in multicentric studies by Bourgoin, Pénélope, Dupont, Thomas, Agabriel, Chantal, Carsin, Ania, Verles, Aurélie, Cabanski, Maciej, Vitaliti, Alessandra, Busnel, Jean‐Marc

“…The Basophil Activation Test (BAT) enables flow cytometry characterization of basophil reactivity against specific allergenic molecules. The focus now revolves…”
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Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer's disease by Farlow, Martin R, Andreasen, Niels, Riviere, Marie-Emmanuelle, Vostiar, Igor, Vitaliti, Alessandra, Sovago, Judit, Caputo, Angelika, Winblad, Bengt, Graf, Ana

“…CAD106 is designed to stimulate amyloid-β (Aβ)-specific antibody responses while avoiding T-cell autoimmune responses. The CAD106 first-in-human study…”
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SO049 / #856 - VERSATILE SUPERHEATED PHASE-CHANGE ULTRASOUND CONTRAST AGENTS FOR HADRON THERAPY DOSIMETRY AND BNCT BOOSTING by Toumia, Yosra, Domenici, Fabio, Pullia, Marco, Facoetti, Angelica, Ferrarini, Michele, Savazzi, Simone, Vitaliti, Alessandra, Tortorella, Elisabetta, Carr, Michael, Fulvio, Angela Di, Paradossi, Gaio

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VERSATILE SUPERHEATED PHASE-CHANGE ULTRASOUND CONTRAST AGENTS FOR HADRON THERAPY DOSIMETRY AND BNCT BOOSTING by Toumia, Yosra, Domenici, Fabio, Pullia, Marco, Facoetti, Angelica, Ferrarini, Michele, Savazzi, Simone, Vitaliti, Alessandra, Tortorella, Elisabetta, Carr, Michael, Fulvio, Angela Di, Paradossi, Gaio

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Biomarker context-of-use: how organizational design can impact the implementation of the appropriate biomarker assay strategy by Cowan, Kyra J, Golob, Michaela, Goodman, Joanne, Laurén, Anna, Andersen, Lene, Decker, Philip De, Dejager, Lien, Fjording, Marianne Scheel, Groenen, Peter, Jasnowski, Renaud, Justies, Nicole, Kimberg, Matti, Kunz, Ulrich, Lawrence, James, Richter, Mario, Sordé, Laetitia, Trigt, Radboud van, Vermet, Laurent, Vitaliti, Alessandra, Wright, Michael, Timmerman, Philip

“…Since 2011, the European Bioanalysis Forum has been discussing the topic of context-of-use for biomarker assays, in support of a cross-industry implementation…”
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2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 - LBA, biomarkers and immunogenicity) by Richards, Susan, Amaravadi, Lakshmi, Pillutla, Renuka, Birnboeck, Herbert, Torri, Albert, Cowan, Kyra J, Papadimitriou, Apollon, Garofolo, Fabio, Satterwhite, Christina, Piccoli, Steven, Wu, Bonnie, Krinos-Fiorotti, Corinna, Allinson, John, Berisha, Flora, Cocea, Laurent, Croft, Stephanie, Fraser, Stephanie, Galliccia, Fabrizio, Gorovits, Boris, Gupta, Swati, Gupta, Vinita, Haidar, Sam, Hottenstein, Charles, Ishii-Watabe, Akiko, Jani, Darshana, Kadavil, John, Kamerud, John, Kramer, Daniel, Litwin, Virginia, Lima Santos, Gustavo Mendes, Nelson, Robert, Ni, Yan, Pedras-Vasconcelos, João, Qiu, Yongchang, Rhyne, Paul, Safavi, Afshin, Saito, Yoshiro, Savoie, Natasha, Scheibner, Kara, Schick, Eginhard, Siguenza, Patricia Y, Smeraglia, John, Staack, Roland F, Subramanyam, Meena, Sumner, Giane, Thway, Theingi, Uhlinger, David, Ullmann, Martin, Vitaliti, Alessandra, Welink, Jan, Whiting, Chan C, Xue, Li, Zeng, Rong

“…The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from…”
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Implementation of highly sophisticated flow cytometry assays in multicenter clinical studies: considerations and guidance by Sommer, Ulrike, Morales, Johanna, Groenewegen, Andrea, Müller, Annemarie, Naab, Julia, Woerly, Gaetane, Kamphausen, Esther, Marsot, Helene, Bennett, Patrick, Kakkanaiah, Vellalore, Vitaliti, Alessandra

“…Flow cytometry is increasingly becoming an important technology for biomarkers used in drug discovery and development. Within clinical development flow…”
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Sotrastaurin and Tacrolimus Coadministration: Effects on Pharmacokinetics and Biomarker Responses by Kovarik, John M., Stitah, Sylvie, Slade, Alan, Vitaliti, Alessandra, Straube, Frank, Grenet, Olivier, Winter, Serge, Sfikas, Nikolaos, Seiberling, Michael

“…Sotrastaurin is an immunosuppressant that inhibits protein kinase C. In the prevention of acute rejection in organ transplantation, sotrastaurin might be…”
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