Search Results - "Vit, Filippo"
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SF3B1 -mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation
Published in Haematologica (Roma) (01-12-2021)“…Chronic lymphocytic leukemia (CLL) is characterized by a low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations…”
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A B-cell receptor-related gene signature predicts response to ibrutinib treatment in mantle cell lymphoma cell lines
Published in Haematologica (Roma) (01-09-2019)Get full text
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P1208: TRANSCRIPTOMIC PROFILING OF B CELL STATES AND MICROENVIROMENTAL ECOSYSTEMS REFINES THE PROGNOSTIC CLASSIFICATION OF DIFFUSE LARGE B CELL LYMPHOMA
Published in HemaSphere (08-08-2023)Get full text
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S143: NATURAL CLONAL EVOLUTION OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH BIMODAL CD49D EXPRESSION REVEALS CD49D PLASTICITY
Published in HemaSphere (08-08-2023)Get full text
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P606: MEASUREMENT OF INTRACLONAL DIVERSIFICATION REFINES THE PROGNOSTIC IMPACT OF IGHV MUTATIONS IN CLL
Published in HemaSphere (08-08-2023)Get full text
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P594: THE CXCR4‐LOW/CD5‐HIGH PROLIFERATIVE FRACTION IS ENRICHED IN BTK MUTATIONS AND ANTICIPATES RELAPSE IN IBRUTINIB‐TREATED CLL
Published in HemaSphere (08-08-2023)Get full text
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Persistence of monoclonal B-cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus-associated lymphoproliferative disorders
Published in British journal of haematology (01-10-2023)“…We investigated 23 hepatitis C virus (HCV)-infected patients with overt lymphoproliferative diseases (15 cases) or monoclonal B lymphocytosis (8 cases) treated…”
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Clinical impact of TP53 disruption in chronic lymphocytic leukemia patients treated with ibrutinib: a campus CLL study
Published in Leukemia (01-04-2023)Get full text
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TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia
Published in Clinical cancer research (15-10-2021)“…In chronic lymphocytic leukemia (CLL), mutations are associated with reduced survival and resistance to standard chemoimmunotherapy (CIT). Nevertheless, the…”
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Early reappearance of intraclonal proliferative subpopulations in ibrutinib-resistant chronic lymphocytic leukemia
Published in Leukemia (01-08-2024)“…The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib represents an effective strategy for treatment of chronic lymphocytic leukemia (CLL), nevertheless about…”
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Reappearance of CXCR4 dim/CD5 bright Proliferative Fraction Associates with BTK Mutations and Anticipates Progression in Ibrutinib-Treated CLL
Published in Blood (02-11-2023)“…Reciprocal expression of CXCR4 and CD5 on the surface of chronic lymphocytic leukemia (CLL) cells can discriminate the proliferative fraction…”
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An Unsupervised Machine Learning Method Stratifies Chronic Lymphocytic Leukemia Patients into Novel Categories with Different Risk of Early Treatment
Published in Blood (02-11-2023)“…Scoring systems designed to improve the accuracy of prognostication in chronic lymphocytic leukemia (CLL) usually rely on discretized/dichotomic values of the…”
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An Unsupervised Machine Learning Method Stratifies Chronic Lymphocytic Leukemia Patients in Novel Categories with Different Risk of Early Treatment
Published in Blood (15-11-2022)Get full text
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Clonal Evolution of Chronic Lymphocytic Leukemia with Bimodal CD49d Expression Reveals CD49d Plasticity
Published in Blood (15-11-2022)Get full text
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The CXCR4dim/CD5bright Proliferative Fraction Reappears in Relapsed CLL Under Ibrutinib, Enriched in BTK Mutations
Published in Blood (15-11-2022)Get full text
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CD49d Expression Is Included in a Revised 4-Factor Model Predicting Outcome in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib: A Multi-Center Real-World Experience
Published in Blood (02-11-2023)“…Introduction. Expression of the CD49d integrin chain has prognostic impact on ibrutinib (IB)-treated CLL patients (Tissino et al, J Exp Med, 2018; Tissino et…”
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Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity
Published in Journal of leukocyte biology (01-04-2019)“…The receptor tyrosine kinase cKit and its ligand stem cell factor are essential for mast cells (MC) development and survival. Strains with mutations affecting…”
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CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer
Published in The Journal of pathology (01-02-2021)“…The CDKN1B gene, encoding for the CDK inhibitor p27kip1, is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine…”
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Follicular lymphoma subgroups with and without t(14;18) differ in their N-glycosylation pattern and IGHV usage
Published in Blood advances (14-12-2021)“…We previously reported that t(14;18)-negative follicular lymphomas (FL) show a clear reduction of newly acquired N-glycosylation sites (NANGS) in…”
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