Search Results - "Viswanatharaju Ruddraraju, Kasi"

SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer by Chen, Hao, Libring, Sarah, Ruddraraju, Kasi Viswanatharaju, Miao, Jinmin, Solorio, Luis, Zhang, Zhong-Yin, Wendt, Michael K.

“…Metastatic breast cancer (MBC) is an extremely recalcitrant disease capable of bypassing current targeted therapies via engagement of several growth promoting…”
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Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides by Viswanatharaju Ruddraraju, Kasi, Parsons, Zachary D, Lewis, Calvin D, Gates, Kent S

“…Allyl sulfides are bioactive phytochemicals found in garlic, onion, and other members of the genus Allium. Here we showed that diallyl disulfide and diallyl…”
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Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis by Ruddraraju, Kasi Viswanatharaju, Aggarwal, Devesh, Zhang, Zhong-Yin

“…Tuberculosis (TB) is an airborne infectious disease caused by (Mtb). According to the World Health Organization, an estimated 10 million people developed TB in…”
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Crystal structure of a nucleoside model for the interstrand cross-link formed by the reaction of 2′-deoxyguanosine and an abasic site in duplex DNA by Catalano, Michael J., Ruddraraju, Kasi Viswanatharaju, Barnes, Charles L., Gates, Kent S.

“…The title compound, 9-[(2 R ,4 S ,5 R )-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-{[(2 R ,4 S ,5 R…”
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Crystal structure of 5-{4′-[(2-{2-[2-(2-ammonioethoxy)ethoxy]ethoxy}ethyl)carbamoyl]-4-methoxy-[1,1′-biphenyl]-3-yl}-3-oxo-1,2,5-thiadiazolidin-2-ide 1,1-dioxide: a potential inhibitor of the enzyme protein tyrosine phosphatase 1B (PTP1B) by Ruddraraju, Kasi Viswanatharaju, Hillebrand, Roman, Barnes, Charles L., Gates, Kent S.

“…The title compound, C 24 H 32 N 4 O 8 S, (I), crystallizes as a zwitterion. The terminal amine N atom of the…”
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Crystal structure of methyl ( S )-2-{( R )-4-[( tert -butoxycarbonyl)amino]-3-oxo-1,2-thiazolidin-2-yl}-3-methylbutanoate: a chemical model for oxidized protein tyrosine phosphatase 1B (PTP1B) by Ruddraraju, Kasi Viswanatharaju, Hillebrand, Roman, Barnes, Charles L., Gates, Kent S.

“…The asymmetric unit of the title compound, C 14 H 24 N 2 O 5 S, contains two independent molecules ( A and B ). In each molecule, the isothiazolidin-3-one ring…”
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Covalent inhibition of protein tyrosine phosphatases by Ruddraraju, Kasi Viswanatharaju, Zhang, Zhong-Yin

“…Protein tyrosine phosphatases (PTPs) are a large family of 107 signaling enzymes that catalyze the hydrolytic removal of phosphate groups from tyrosine…”
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Highly Potent and Selective N‑Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Ruddraraju, Kasi Viswanatharaju, Aggarwal, Devesh, Niu, Congwei, Baker, Erica Anne, Zhang, Ruo-yu, Wu, Li, Zhang, Zhong-Yin

“…Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). Mtb protein tyrosine phosphatase B (mPTPB) is a virulence…”
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Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor–Electrophile Conjugate by Punthasee, Puminan, Laciak, Adrian R, Cummings, Andrea H, Ruddraraju, Kasi Viswanatharaju, Lewis, Sarah M, Hillebrand, Roman, Singh, Harkewal, Tanner, John J, Gates, Kent S

“…Protein tyrosine phosphatase 1B (PTP1B) is a validated drug target, but it has proven difficult to develop medicinally useful, reversible inhibitors of this…”
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Reactions of 1,3-Diketones with a Dipeptide Isothiazolidin-3-one: Toward Agents That Covalently Capture Oxidized Protein Tyrosine Phosphatase 1B by Ruddraraju, Kasi Viswanatharaju, Parsons, Zachary D, Llufrio, Elizabeth M, Frost, Natasha L, Gates, Kent S

“…Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for the treatment of type 2 diabetes; however, the enzyme has been classified by some…”
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Correction to “Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides” by Ruddraraju, Kasi Viswanatharaju, Parsons, Zachary D, Lewis, Calvin D, Gates, Kent S

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Sulfone-stabilized carbanions for the reversible covalent capture of a posttranslationally-generated cysteine oxoform found in protein tyrosine phosphatase 1B (PTP1B) by Parsons, Zachary D., Ruddraraju, Kasi Viswanatharaju, Santo, Nicholas, Gates, Kent S.

“…[Display omitted] Redox regulation of protein tyrosine phosphatase 1B (PTP1B) involves oxidative conversion of the active site cysteine thiolate into an…”
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Crystal structure of methyl (S)-2-{(R)-4-[(tert-but-oxy-carbon-yl)amino]-3-oxo-1,2-thia-zolidin-2-yl}-3-methyl-butano-ate: a chemical model for oxidized protein tyrosine phosphatase 1B (PTP1B) by Ruddraraju, Kasi Viswanatharaju, Hillebrand, Roman, Barnes, Charles L, Gates, Kent S

“…The asymmetric unit of the title compound, C14H24N2O5S, contains two independent mol-ecules (A and B). In each mol-ecule, the iso-thia-zolidin-3-one ring…”
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Crystal structure of a nucleoside model for the inter-strand cross-link formed by the reaction of 2'-de-oxy-guanosine and an abasic site in duplex DNA by Catalano, Michael J, Ruddraraju, Kasi Viswanatharaju, Barnes, Charles L, Gates, Kent S

“…The title compound,…”
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Crystal structure of 5-{4'-[(2-{2-[2-(2-ammonio-eth-oxy)eth-oxy]eth-oxy}eth-yl)carbamo-yl]-4-meth-oxy-[1,1'-biphen-yl]-3-yl}-3-oxo-1,2,5-thia-diazo-lidin-2-ide 1,1-dioxide: a potential inhibitor of the enzyme protein tyrosine phosphatase 1B (PTP1B) by Ruddraraju, Kasi Viswanatharaju, Hillebrand, Roman, Barnes, Charles L, Gates, Kent S

“…The title compound, C24H32N4O8S, (I), crystallizes as a zwitterion. The terminal amine N atom of the…”
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