Search Results - "Vistoli, Giulio"

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs by Artasensi, Angelica, Pedretti, Alessandro, Vistoli, Giulio, Fumagalli, Laura

“…Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization…”
Get full text

Reactions and enzymes in the metabolism of drugs and other xenobiotics by Testa, Bernard, Pedretti, Alessandro, Vistoli, Giulio

“…In this article, we offer an overview of the compared quantitative importance of biotransformation reactions in the metabolism of drugs and other xenobiotics,…”
Get full text

Obesity and Type 2 Diabetes: Adiposopathy as a Triggering Factor and Therapeutic Options by Artasensi, Angelica, Mazzolari, Angelica, Pedretti, Alessandro, Vistoli, Giulio, Fumagalli, Laura

“…Obesity and type 2 diabetes (T2DM) are major public health concerns associated with serious morbidity and increased mortality. Both obesity and T2DM are…”
Get full text

Enzymatic and non-enzymatic detoxification of 4-hydroxynonenal: Methodological aspects and biological consequences by Mol, Marco, Regazzoni, Luca, Altomare, Alessandra, Degani, Genny, Carini, Marina, Vistoli, Giulio, Aldini, Giancarlo

“…4-Hydroxynonenal (HNE), an electrophilic end-product deriving from lipid peroxidation, undergoes a heterogeneous set of biotransformations including enzymatic…”
Get full text

MetaClass, a Comprehensive Classification System for Predicting the Occurrence of Metabolic Reactions Based on the MetaQSAR Database by Mazzolari, Angelica, Scaccabarozzi, Alice, Vistoli, Giulio, Pedretti, Alessandro

“…(1) Background: Machine learning algorithms are finding fruitful applications in predicting the ADME profile of new molecules, with a particular focus on…”
Get full text

Exscalate4CoV: Innovative High Performing Computing (HPC) Strategies to Tackle Pandemic Crisis by Beccari, Andrea R., Vistoli, Giulio

“…This Special Issue was intended as a dissemination forum where the major results pursued by the EXSCALATE4CoV project (E4C, https://www [...]…”
Get full text

Exploring Secondary Amine Carnosine Derivatives: Design, Synthesis, and Properties by Artasensi, Angelica, Mazzotta, Sarah, Sanz, Ines, Lin, Licheng, Vistoli, Giulio, Fumagalli, Laura, Regazzoni, Luca

“…Carnosine is a naturally occurring dipeptide that has been advocated by some authors as an interesting scaffold for the development of potential therapeutic…”
Get full text

FAME 3: Predicting the Sites of Metabolism in Synthetic Compounds and Natural Products for Phase 1 and Phase 2 Metabolic Enzymes by Šícho, Martin, Stork, Conrad, Mazzolari, Angelica, de Bruyn Kops, Christina, Pedretti, Alessandro, Testa, Bernard, Vistoli, Giulio, Svozil, Daniel, Kirchmair, Johannes

“…In this work we present the third generation of FAst MEtabolizer (FAME 3), a collection of extra trees classifiers for the prediction of sites of metabolism…”
Get full text

MetaTREE, a Novel Database Focused on Metabolic Trees, Predicts an Important Detoxification Mechanism: The Glutathione Conjugation by Mazzolari, Angelica, Sommaruga, Luca, Pedretti, Alessandro, Vistoli, Giulio

“…(1) Background: Data accuracy plays a key role in determining the model performances and the field of metabolism prediction suffers from the lack of truly…”
Get full text

A carnosine analog mitigates metabolic disorders of obesity by reducing carbonyl stress by Anderson, Ethan J, Vistoli, Giulio, Katunga, Lalage A, Funai, Katsuhiko, Regazzoni, Luca, Monroe, T Blake, Gilardoni, Ettore, Cannizzaro, Luca, Colzani, Mara, De Maddis, Danilo, Rossoni, Giuseppe, Canevotti, Renato, Gagliardi, Stefania, Carini, Marina, Aldini, Giancarlo

“…Sugar- and lipid-derived aldehydes are reactive carbonyl species (RCS) frequently used as surrogate markers of oxidative stress in obesity. A pathogenic role…”
Get full text

Rescoring and Linearly Combining: A Highly Effective Consensus Strategy for Virtual Screening Campaigns by Pedretti, Alessandro, Mazzolari, Angelica, Gervasoni, Silvia, Vistoli, Giulio

“…The study proposes a novel consensus strategy based on linear combinations of different docking scores to be used in the evaluation of virtual screening…”
Get full text

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products by Aldini, Giancarlo, Vistoli, Giulio, Stefek, Milan, Chondrogianni, N, Grune, Tilman, Sereikaite, Jolanta, Sadowska-Bartosz, Izabela, Bartosz, Grzegorz

“…The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other…”
Get more information

3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors by Laurino, Annunziatina, Matucci, Rosanna, Vistoli, Giulio, Raimondi, Laura

“…3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled…”
Get full text

Hempseed ( Cannabis sativa ) Peptide H3 (IGFLIIWV) Exerts Cholesterol-Lowering Effects in Human Hepatic Cell Line by Li, Jianqiang, Bollati, Carlotta, Bartolomei, Martina, Mazzolari, Angelica, Arnoldi, Anna, Vistoli, Giulio, Lammi, Carmen

“…Hempseed ( ) protein is an important source of bioactive peptides. H3 (IGFLIIWV), a transepithelial transported intestinal peptide obtained from the hydrolysis…”
Get full text

Prediction of the Formation of Reactive Metabolites by A Novel Classifier Approach Based on Enrichment Factor Optimization (EFO) as Implemented in the VEGA Program by Mazzolari, Angelica, Vistoli, Giulio, Testa, Bernard, Pedretti, Alessandro

“…The study is aimed at developing linear classifiers to predict the capacity of a given substrate to yield reactive metabolites. While most of the hitherto…”
Get full text

Behavior of three hypocholesterolemic peptides from soy protein in an intestinal model based on differentiated Caco-2 cell by Aiello, Gilda, Ferruzza, Simonetta, Ranaldi, Giulia, Sambuy, Yula, Arnoldi, Anna, Vistoli, Giulio, Lammi, Carmen

“…[Display omitted] •IAVPGEVA, IAVPTGVA, and LPYP, 3 soy peptides, are absorbed by Caco-2 cells.•A specific LC-MRM method was developed for their…”
Get full text

Target Prediction by Multiple Virtual Screenings: Analyzing the SARS-CoV-2 Phenotypic Screening by the Docking Simulations Submitted to the MEDIATE Initiative by Gervasoni, Silvia, Manelfi, Candida, Adobati, Sara, Talarico, Carmine, Biswas, Akash Deep, Pedretti, Alessandro, Vistoli, Giulio, Beccari, Andrea R

“…Phenotypic screenings are usually combined with deconvolution techniques to characterize the mechanism of action for the retrieved hits. These studies can be…”
Get full text

MetaSpot: A General Approach for Recognizing the Reactive Atoms Undergoing Metabolic Reactions Based on the MetaQSAR Database by Mazzolari, Angelica, Perazzoni, Pietro, Sabato, Emanuela, Lunghini, Filippo, Beccari, Andrea R, Vistoli, Giulio, Pedretti, Alessandro

“…The prediction of drug metabolism is attracting great interest for the possibility of discarding molecules with unfavorable ADME/Tox profile at the early stage…”
Get full text

WarpEngine, a Flexible Platform for Distributed Computing Implemented in the VEGA Program and Specially Targeted for Virtual Screening Studies by Pedretti, Alessandro, Mazzolari, Angelica, Vistoli, Giulio

“…The manuscript describes WarpEngine, a novel platform implemented within the VEGA ZZ suite of software for performing distributed simulations both in local and…”
Get full text

A Comprehensive Mapping of the Druggable Cavities within the SARS-CoV-2 Therapeutically Relevant Proteins by Combining Pocket and Docking Searches as Implemented in Pockets 2.0 by Gervasoni, Silvia, Vistoli, Giulio, Talarico, Carmine, Manelfi, Candida, Beccari, Andrea R, Studer, Gabriel, Tauriello, Gerardo, Waterhouse, Andrew Mark, Schwede, Torsten, Pedretti, Alessandro

“…(1) Background: Virtual screening studies on the therapeutically relevant proteins of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) require…”
Get full text