Search Results - "Vissers, Joseph H.A"

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling by Mattiroli, Francesca, Vissers, Joseph H.A., van Dijk, Willem J., Ikpa, Pauline, Citterio, Elisabetta, Vermeulen, Wim, Marteijn, Jurgen A., Sixma, Titia K.

“…Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting…”
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A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth by Vissers, Joseph H.A., Manning, Samuel A., Kulkarni, Aishwarya, Harvey, Kieran F.

“…Libraries of transgenic Drosophila melanogaster carrying RNA interference (RNAi) constructs have been used extensively to perform large-scale functional…”
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The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate by Vissers, Joseph H.A., Froldi, Francesca, Schröder, Jan, Papenfuss, Anthony T., Cheng, Louise Y., Harvey, Kieran F.

“…The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scalloped (Sd) and Nervous…”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells by Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“…Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification…”
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Inter-subunit interactions that coordinate Rad51's activities by Grigorescu, Arabela A, Vissers, Joseph H.A, Ristic, Dejan, Pigli, Ying Z, Lynch, Thomas W, Wyman, Claire, Rice, Phoebe A

“…Rad51 is the central catalyst of homologous recombination in eukaryotes and is thus critical for maintaining genomic integrity. Recent crystal structures of…”
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Abstract B10: Evaluating YAP and TAZ as therapeutic targets for treating malignant mesothelioma with Hippo pathway disruptions by Kulkarni, Aishwarya S., Vissers, Joseph H.A., Harvey, Kieran F.

“…Malignant mesotheliomas (MMs) are tumors originating from the mesothelial lining of internal organs. Hippo pathway disruptions are common in MMs; up to 50% of…”
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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer by Vervoort, Stephin J., Welsh, Sarah A., Devlin, Jennifer R., Barbieri, Elisa, Knight, Deborah A., Offley, Sarah, Bjelosevic, Stefan, Costacurta, Matteo, Todorovski, Izabela, Kearney, Conor J., Sandow, Jarrod J., Fan, Zheng, Blyth, Benjamin, McLeod, Victoria, Vissers, Joseph H.A., Pavic, Karolina, Martin, Ben P., Gregory, Gareth, Demosthenous, Elena, Zethoven, Magnus, Kong, Isabella Y., Hawkins, Edwin D., Hogg, Simon J., Kelly, Madison J., Newbold, Andrea, Simpson, Kaylene J., Kauko, Otto, Harvey, Kieran F., Ohlmeyer, Michael, Westermarck, Jukka, Gray, Nathanael, Gardini, Alessandro, Johnstone, Ricky W.

“…Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints during the transcription cycle…”
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The JNK and Hippo pathways control epithelial integrity and prevent tumor initiation by regulating an overlapping transcriptome by Mitchell, Katrina A, Vissers, Joseph H A, Pojer, Jonathan M, Brooks, Elliot, Hilmi, Abdul Jabbar Saiful, Papenfuss, Anthony T, Schröder, Jan, Harvey, Kieran F

“…Epithelial organs maintain their integrity and prevent tumor initiation by actively removing defective cells, such as those that have lost apicobasal polarity…”
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The emerging role of Polycomb repressors in the response to DNA damage by Vissers, Joseph H A, van Lohuizen, Maarten, Citterio, Elisabetta

“…Polycomb group (PcG) genes encode chromatin modifiers that are involved in the maintenance of cell identity and in proliferation, processes that are often…”
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A rare diagnostically challenging case of CIC-DUX4 sarcoma arising in the neck by Aranza, Stefanie, Roydhouse, Christina, Mitchell, Catherine, Vissers, Joseph H.A., Lo, Wing-Yee, Grimmond, Sean M., Kho, Jane

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Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi by Vissers, Joseph H A, Dent, Lucas G, House, Colin M, Kondo, Shu, Harvey, Kieran F

“…Abstract The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the context of organ…”
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Human USP3 Is a Chromatin Modifier Required for S Phase Progression and Genome Stability by Nicassio, Francesco, Corrado, Nadia, Vissers, Joseph H.A., Areces, Liliana B., Bergink, Steven, Marteijn, Jurgen A., Geverts, Bart, Houtsmuller, Adriaan B., Vermeulen, Wim, Di Fiore, Pier Paolo, Citterio, Elisabetta

“…Protein ubiquitination is critical for numerous cellular functions, including DNA damage response pathways [1, 2]. Histones are the most abundant monoubiquitin…”
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Targeting homologous recombination deficiency in uterine leiomyosarcoma by Dall, Genevieve, Vandenberg, Cassandra J, Nesic, Ksenija, Ratnayake, Gayanie, Zhu, Wenying, Vissers, Joseph H A, Bedő, Justin, Penington, Jocelyn, Wakefield, Matthew J, Kee, Damien, Carmagnac, Amandine, Lim, Ratana, Shield-Artin, Kristy, Milesi, Briony, Lobley, Amanda, Kyran, Elizabeth L, O'Grady, Emily, Tram, Joshua, Zhou, Warren, Nugawela, Devindee, Stewart, Kym Pham, Caldwell, Reece, Papadopoulos, Lia, Ng, Ashley P, Dobrovic, Alexander, Fox, Stephen B, McNally, Orla, Power, Jeremy D, Meniawy, Tarek, Tan, Teng Han, Collins, Ian M, Klein, Oliver, Barnett, Stephen, Olesen, Inger, Hamilton, Anne, Hofmann, Oliver, Grimmond, Sean, Papenfuss, Anthony T, Scott, Clare L, Barker, Holly E

“…Uterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of < 10%…”
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A Matched Molecular and Clinical Analysis of the Epithelioid Haemangioendothelioma Cohort in the Stafford Fox Rare Cancer Program and Contextual Literature Review by Abdelmogod, Arwa, Papadopoulos, Lia, Riordan, Stephen, Wong, Melvin, Weltman, Martin, Lim, Ratana, McEvoy, Christopher, Fellowes, Andrew, Fox, Stephen, Bedő, Justin, Penington, Jocelyn, Pham, Kym, Hofmann, Oliver, Vissers, Joseph H. A., Grimmond, Sean, Ratnayake, Gayanie, Christie, Michael, Mitchell, Catherine, Murray, William K., McClymont, Kelly, Luk, Peter, Papenfuss, Anthony T., Kee, Damien, Scott, Clare L., Goldstein, David, Barker, Holly E.

“…Background: Epithelioid haemangioendothelioma (EHE) is an ultra-rare malignant vascular tumour with a prevalence of 1 per 1,000,000. It is typically…”
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Clinical Impact of Comprehensive Molecular Profiling in Adolescents and Young Adults with Sarcoma by Andrew, Eden C, Lewin, Jeremy, Desai, Jayesh, Orme, Lisa, Hamilton, Anne, Bae, Susie, Zhu, Wenying, Nicolson, Shannon, Varghese, Leila N, Mitchell, Camilla B, Vissers, Joseph H A, Xu, Huiling, Grimmond, Sean M, Fox, Stephen B, Luen, Stephen J

“…Sarcomas are a heterogenous group of tumours that commonly carry poor prognosis with limited therapeutic options. Adolescents and young adults (AYAs) with…”
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Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3 by Thilakasiri, Pathum, O'Keefe, Ryan N, To, Sarah Q, Chisanga, David, Eissmann, Moritz F, Carli, Annalisa LE, Duscio, Belinda, Baloyan, David, Dmello, Rhynelle S, Williams, David, Mariadason, John, Poh, Ashleigh R, Pal, Bhupinder, Kile, Benjamin T, Vissers, Joseph Ha, Harvey, Kieran F, Buchert, Michael, Shi, Wei, Ernst, Matthias, Chand, Ashwini L

“…Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In the context of gastric cancer, YAP1 is a biomarker for poor…”
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Novel RET Fusion RET-SEPTIN9 Predicts Response to Selective RET Inhibition With Selpercatinib in Malignant Pheochromocytoma by Mweempwa, Angela, Xu, Huiling, Vissers, Joseph H A, Tothill, Richard W, Pattison, Andrew D, Fellowes, Andrew P, Thomas, David M, Richardson, Gary, Hicks, Rodney J, Grimmond, Sean M, Fox, Stephen B, Luen, Stephen J, Desai, Jayesh, Solomon, Benjamin J

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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells by Lancini, Cesare, van den Berk, Paul C.M., Vissers, Joseph H.A., Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

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A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation by Westerman, Bart A, Braat, A Koen, Taub, Nicole, Potman, Marko, Vissers, Joseph H A, Blom, Marleen, Verhoeven, Els, Stoop, Hans, Gillis, Ad, Velds, Arno, Nijkamp, Wouter, Beijersbergen, Roderick, Huber, Lukas A, Looijenga, Leendert H J, van Lohuizen, Maarten

“…Despite intense investigation of intrinsic and extrinsic factors that regulate pluripotency, the process of initial fate commitment of embryonic stem (ES)…”
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The many faces of ubiquitinated histone H2A: insights from the DUBs by Vissers, Joseph Ha, Nicassio, Francesco, van Lohuizen, Maarten, Di Fiore, Pier Paolo, Citterio, Elisabetta

“…Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in…”
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