Search Results - "Visser, Gerard W.M."

Immuno‐PET: A Navigator in Monoclonal Antibody Development and Applications by van Dongen, Guus A.M.S., Visser, Gerard W.M., Lub‐de Hooge, Marjolijn N., de Vries, Elisabeth G., Perk, Lars R.

“…Learning Objectives After completing this course, the reader will be able to: Discuss the technical advances that have led to recent rapid developments in…”
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Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p -isothiocyanatobenzyl-desferrioxamine by van Dongen, Guus A M S, Vosjan, Maria J W D, Perk, Lars R, Visser, Gerard W M, Budde, Marianne, Jurek, Paul, Kiefer, Garry E

“…The positron emitter zirconium-89 ( 89 Zr) has very attractive properties for positron emission tomography (PET) imaging of intact monoclonal antibodies (mAbs)…”
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Inert coupling of IRDye800CW and zirconium-89 to monoclonal antibodies for single- or dual-mode fluorescence and PET imaging by Cohen, Ruth, Vugts, Danielle J, Stigter-van Walsum, Marijke, Visser, Gerard W M, van Dongen, Guus A M S

“…IRDye800CW and zirconium-89 ( 89 Zr) have very attractive properties for optical imaging and positron emission tomography (PET) imaging, respectively. Here we…”
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The Promise of Immuno-PET in Radioimmunotherapy by Verel, Iris, Visser, Gerard W.M, van Dongen, Guus A

“…Immuno-PET as a quantitative imaging procedure before or concomitant with radioimmunotherapy is an attractive option to improve confirmation of tumor targeting…”
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Long-lived positron emitters zirconium-89 and iodine-124 for scouting of therapeutic radioimmunoconjugates with PET by Verel, Iris, Visser, Gerard W M, Boerman, Otto C, van Eerd, Julliette E M, Finn, Ron, Boellaard, Ronald, Vosjan, Maria J W D, Stigter-van Walsum, Marijke, Snow, Gordon B, van Dongen, Guus A M S

“…Antibody-PET imaging might be of value for the selection of radioimmunotherapy (RIT) candidates to confirm tumor targeting and to estimate radiation doses to…”
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Targeting of a hydrophilic photosensitizer by use of internalizing monoclonal antibodies: A new possibility for use in photodynamic therapy by Vrouenraets, Maarten B., Visser, Gerard W.M., Loup, Christophe, Meunier, Bernard, Stigter, Marijke, Oppelaar, Hugo, Stewart, Fiona A., Snow, Gordon B., van Dongen, Guus A.M.S.

“…Coupling of photosensitizers to tumor‐selective monoclonal antibodies (MAbs) is an attractive option for improving the selectivity of photodynamic therapy…”
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Monoclonal Antibodies Labeled with Rhenium-186 Using the MAG3 Chelate: Relationship between the Number of Chelated Groups and Biodistribution Characteristics by van Gog, Frank B, Visser, Gerard W.M, Klok, Rob, van der Schors, Roel, Snow, Gordon B, van Dongen, Guus A.M.S

“…Our previous studies on the preparation of 186Re-MAb conjugates for clinical radioimmunotherapy (RIT) were extended with the aim to derive conjugates which…”
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Development of novel ADCs: conjugation of tubulysin analogues to trastuzumab monitored by dual radiolabeling by Cohen, Ruth, Vugts, Danielle J, Visser, Gerard W M, Stigter-van Walsum, Marijke, Bolijn, Marije, Spiga, Marco, Lazzari, Paolo, Shankar, Sreejith, Sani, Monica, Zanda, Matteo, van Dongen, Guus A M S

“…Tubulysins are highly toxic tubulin-targeting agents with a narrow therapeutic window that are interesting for application in antibody-drug conjugates (ADC)…”
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p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging by Perk, Lars R., Vosjan, Maria J. W. D., Visser, Gerard W. M., Budde, Marianne, Jurek, Paul, Kiefer, Garry E., van Dongen, Guus A. M. S.

“…Purpose Immuno-PET is an emerging imaging tool for the selection of high potential antibodies (mAbs) for imaging and therapy. The positron emitter zirconium-89…”
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(89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab by Perk, Lars R, Visser, Gerard W M, Vosjan, Maria J W D, Stigter-van Walsum, Marijke, Tijink, Bernard M, Leemans, C René, van Dongen, Guus A M S

“…Immuno-PET as a scouting procedure before radioimmunotherapy (RIT) aims at confirming tumor targeting and accurately estimating radiation dose delivery to both…”
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(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy by Tijink, Bernard M, Perk, Lars R, Budde, Marianne, Stigter-van Walsum, Marijke, Visser, Gerard W M, Kloet, Reina W, Dinkelborg, Ludger M, Leemans, C René, Neri, Dario, van Dongen, Guus A M S

“…The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical…”
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Synthesis of Phosphine and Antibody–Azide Probes for in Vivo Staudinger Ligation in a Pretargeted Imaging and Therapy Approach by Vugts, Danielle J, Vervoort, Annelies, Stigter-van Walsum, Marijke, Visser, Gerard W. M, Robillard, Marc S, Versteegen, Ron M, Vulders, Roland C. M, Herscheid, J. (Koos) D. M, van Dongen, Guus A. M. S

“…The application of intact monoclonal antibodies (mAbs) as targeting agents in nuclear imaging and radioimmunotherapy is hampered by the slow pharmacokinetics…”
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Basic principles, applications in oncology and improved selectivity of photodynamic therapy by Vrouenraets, Maarten B, Visser, Gerard W M, Snow, Gordon B, van Dongen, Guus A M S

“…Photodynamic therapy (PDT) is a promising approach for the treatment of superficially localized tumors. This review starts with a summary of the basic…”
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Preparation and evaluation of (89)Zr-Zevalin for monitoring of (90)Y-Zevalin biodistribution with positron emission tomography by Perk, Lars R, Visser, Otto J, Stigter-van Walsum, M, Vosjan, Maria J W D, Visser, Gerard W M, Zijlstra, Josée M, Huijgens, Peter C, van Dongen, Guus A M S

“…To evaluate whether (89)Zr can be used as a PET surrogate label for quantification of (90)Y-ibritumomab tiuxetan ((90)Y-Zevalin) biodistribution and dosimetry…”
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Nanocolloidal albumin-IRDye 800CW: a near-infrared fluorescent tracer with optimal retention in the sentinel lymph node by Heuveling, Derrek A., Visser, Gerard W. M., de Groot, Mattijs, de Boer, Johannes F., Baclayon, Marian, Roos, Wouter H., Wuite, Gijs J. L., Leemans, C. René, de Bree, Remco, van Dongen, Guus A. M. S.

“…Purpose At present, the only approved fluorescent tracer for clinical near-infrared fluorescence-guided sentinel node (SN) detection is indocyanine green…”
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Inert coupling of IRDye800CW to monoclonal antibodies for clinical optical imaging of tumor targets by Cohen, Ruth, Stammes, Marieke A, de Roos, Inge HC, Stigter-van Walsum, Marijke, Visser, Gerard WM, van Dongen, Guus AMS

“…Background Photoimmunodetection, in which monoclonal antibodies [mAbs] are labeled with fluorescent dyes, might have clinical potential for early detection and…”
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89 Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results by Heuveling, Derrek A., Visser, Gerard W.M., Baclayon, Marian, Roos, Wouter H., Wuite, Gijs J.L., Hoekstra, Otto S., Leemans, C. René, de Bree, Remco, van Dongen, Guus A.M.S.

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Targeting of aluminum (III) phthalocyanine tetrasulfonate by use of internalizing monoclonal antibodies : Improved efficacy in photodynamic therapy by VROUENRAETS, Maarten B, VISSER, Gerard W. M, STIGTER, Marijke, OPPELAAR, Hugo, SNOW, Gordon B, VAN DONGEN, Guus A. M. S

“…The use of monoclonal antibodies (MAbs) directed against tumor-associated antigens for targeting of photosensitizers is an interesting option to improve the…”
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The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule by van Uhm, Janneke IM, Visser, Gerard WM, van der Schans, Marcel J, Geldof, Albert A, Meuleman, Eric JH, Nieuwenhuijzen, Jakko A

“…Background Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of…”
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Comparison of aluminium (III) phthalocyanine tetrasulfonate‐ and meta‐tetrahydroxyphenylchlorin‐monoclonal antibody conjugates for their efficacy in photodynamic therapy in vitro by Vrouenraets, Maarten B., Visser, Gerard W.M., Stigter, Marÿke, Oppelaar, Hugo, Snow, Gordon B., van Dongen, Guus A.M.S.

“…A challenge in photodynamic therapy (PDT) is to improve the tumour selectivity of the photosensitizers by using monoclonal antibodies (MAbs). With this aim, we…”
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