Search Results - "Visscher, P. M."

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood by LEE, S. H, YANG, J, GODDARD, M. E, VISSCHER, P. M, WRAY, N. R

“…Genetic correlations are the genome-wide aggregate effects of causal variants affecting multiple traits. Traditionally, genetic correlations between complex…”
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L by Benyamin, B, Pourcain, BSt, Davis, O S, Davies, G, Hansell, N K, Brion, M-JA, Kirkpatrick, R M, Cents, R A M, Franić, S, Miller, M B, Haworth, C M A, Meaburn, E, Price, T S, Evans, D M, Timpson, N, Kemp, J, Ring, S, McArdle, W, Medland, S E, Yang, J, Harris, S E, Liewald, D C, Scheet, P, Xiao, X, Hudziak, J J, de Geus, E J C, Jaddoe, V W V, Starr, J M, Verhulst, F C, Pennell, C, Tiemeier, H, Iacono, W G, Palmer, L J, Montgomery, G W, Martin, N G, Boomsma, D I, Posthuma, D, McGue, M, Wright, M J, Davey Smith, G, Deary, I J, Plomin, R, Visscher, P M

“…Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational…”
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DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12 by Trzaskowski, M, Yang, J, Visscher, P M, Plomin, R

“…Two genetic findings from twin research have far-reaching implications for understanding individual differences in the development of brain function as indexed…”
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Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses by Visscher, P M, Goddard, M E, Derks, E M, Wray, N R

“…In this article, we review some of the data that contribute to our understanding of the genetic architecture of psychiatric disorders. These include results…”
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Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia by Lips, E S, Cornelisse, L N, Toonen, R F, Min, J L, Hultman, C M, Holmans, P A, O'Donovan, M C, Purcell, S M, Smit, A B, Verhage, M, Sullivan, P F, Visscher, P M, Posthuma, D

“…Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ∼1%. Previous studies have implicated…”
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Genome-wide association studies establish that human intelligence is highly heritable and polygenic by Davies, G, Tenesa, A, Payton, A, Yang, J, Harris, S E, Liewald, D, Ke, X, Le Hellard, S, Christoforou, A, Luciano, M, McGhee, K, Lopez, L, Gow, A J, Corley, J, Redmond, P, Fox, H C, Haggarty, P, Whalley, L J, McNeill, G, Goddard, M E, Espeseth, T, Lundervold, A J, Reinvang, I, Pickles, A, Steen, V M, Ollier, W, Porteous, D J, Horan, M, Starr, J M, Pendleton, N, Visscher, P M, Deary, I J

“…General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in…”
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Assessing the genetic overlap between BMI and cognitive function by Marioni, R E, Yang, J, Dykiert, D, Mõttus, R, Campbell, A, Davies, G, Hayward, C, Porteous, D J, Visscher, P M, Deary, I J

“…Obesity and low cognitive function are associated with multiple adverse health outcomes across the life course. They have a small phenotypic correlation ( r…”
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Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain by Richards, A L, Jones, L, Moskvina, V, Kirov, G, Gejman, P V, Levinson, D F, Sanders, A R, Purcell, S, Visscher, P M, Craddock, N, Owen, M J, Holmans, P, O'Donovan, M C

“…It is widely thought that alleles that influence susceptibility to common diseases, including schizophrenia, will frequently do so through effects on gene…”
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Localized Negative Genetic Correlation Constrains Microevolution of Coat Color in Wild Sheep by Gratten, J, Wilson, A.J, McRae, A.F, Beraldi, D, Visscher, P.M, Pemberton, J.M, Slate, J

“…The evolutionary changes that occur over a small number of generations in natural populations often run counter to what is expected on the basis of the…”
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Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data by Chen, Guo-Bo, Lee, Sang Hong, Brion, Marie-Jo A, Montgomery, Grant W, Wray, Naomi R, Radford-Smith, Graham L, Visscher, Peter M

“…As custom arrays are cheaper than generic GWAS arrays, larger sample size is achievable for gene discovery. Custom arrays can tag more variants through denser…”
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A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing by Davies, G, Harris, S E, Reynolds, C A, Payton, A, Knight, H M, Liewald, D C, Lopez, L M, Luciano, M, Gow, A J, Corley, J, Henderson, R, Murray, C, Pattie, A, Fox, H C, Redmond, P, Lutz, M W, Chiba-Falek, O, Linnertz, C, Saith, S, Haggarty, P, McNeill, G, Ke, X, Ollier, W, Horan, M, Roses, A D, Ponting, C P, Porteous, D J, Tenesa, A, Pickles, A, Starr, J M, Whalley, L J, Pedersen, N L, Pendleton, N, Visscher, P M, Deary, I J

“…Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated…”
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708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits by Thomson, P A, Parla, J S, McRae, A F, Kramer, M, Ramakrishnan, K, Yao, J, Soares, D C, McCarthy, S, Morris, S W, Cardone, L, Cass, S, Ghiban, E, Hennah, W, Evans, K L, Rebolini, D, Millar, J K, Harris, S E, Starr, J M, MacIntyre, D J, McIntosh, A M, Watson, J D, Deary, I J, Visscher, P M, Blackwood, D H, McCombie, W R, Porteous, D J

“…A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and…”
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Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits by Rietveld, Cornelius A., Conley, Dalton, Eriksson, Nicholas, Esko, Tõnu, Medland, Sarah E., Vinkhuyzen, Anna A. E., Yang, Jian, Boardman, Jason D., Chabris, Christopher F., Dawes, Christopher T., Domingue, Benjamin W., Hinds, David A., Johannesson, Magnus, Kiefer, Amy K., Laibson, David, Magnusson, Patrik K. E., Mountain, Joanna L., Oskarsson, Sven, Rostapshova, Olga, Teumer, Alexander, Tung, Joyce Y., Visscher, Peter M., Benjamin, Daniel J., Cesarini, David, Koellinger, Philipp D.

“…A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their…”
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Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome by Benyamin, B, Sørensen, T. I. A, Schousboe, K, Fenger, M, Visscher, P. M, Kyvik, K. O

“…Aims/hypothesis The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor…”
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A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42 by MACGREGOR, S, VISSCHER, P. M, KNOTT, S. A, THOMSON, P, PORTEOUS, D. J, MILLAR, J. K, DEVON, R. S, BLACKWOOD, D, MUIR, W. J

“…In this study, we report a genome scan for psychiatric disease susceptibility loci in 13 Scottish families. We follow up one of the linkage peaks on chromosome…”
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Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936 by Houlihan, L. M., Harris, S. E., Luciano, M., Gow, A. J., Starr, J. M., Visscher, P. M., Deary, I. J.

“…As the proportion of older people in societies has increased, research into the determinants of cognitive ageing has risen in importance. Genetic influences…”
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Twin study of genetic and environmental influences on adult body size, shape, and composition by SCHOUSBOE, K, VISSCHER, P. M, ERBAS, B, KYVIK, K. O, HOPPER, J. L, HENRIKSEN, J. E, HEITMANN, B. L, SØRENSEN, T. I. A

“…To investigate the genetic and environmental influences on adult body size, shape, and composition in women and men, and to assess the impact of age. In this…”
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Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins by Hur, Y.M, Kaprio, J, Iacono, W.G, Boomsma, D.I, McGue, M, Silventoinen, K, Martin, N.G, Luciano, M, Visscher, P.M, Rose, R.J, He, M, Ando, J, Ooki, S, Nonaka, K, Lin, C.C.H, Lajunen, H.R

“…Objective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were…”
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Estimation of pedigree errors in the UK dairy population using microsatellite markers and the impact on selection by Visscher, P M, Woolliams, J A, Smith, D, Williams, J L

“…The proportion of cows in the UK dairy herd whose sires were misidentified was estimated using DNA markers. Genetic marker genotypes were determined on 568…”
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Confidence intervals in QTL mapping by bootstrapping by Visscher, P.M. (University of Edinburgh, Edinburgh, Scotland.), Thompson, R, Haley, C.S

“…The determination of empirical confidence intervals for the location of quantitative trait loci(QTLs) was investigated using simulation. Empirical confidence…”
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