Search Results - "Visor, Gary C."

Glass Vials for Small Volume Parenterals: Influence of Drug and Manufacturing Processes on Glass Delamination by Ennis, Richard D., Pritchard, Ray, Nakamura, Carey, Coulon, Michael, Yang, Taiyin, Visor, Gary C., Lee, William A.

“…Purpose: Studies were initiated to examine the effect of formulation and process variables on the delamination process and also the influence of the glass…”
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Enhanced chemical stability of the intracellular prodrug, 1-[(( S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, relative to its parent compound, cidofovir by Oliyai, Reza, Lee, William A, Visor, Gary C, Yuan, Lung-Chi

“…Degradation kinetics of cyclic HPMPC (cHPMPC), 1-[(( S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, and its parent compound cidofovir (also…”
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Stability of interleukin 1β (IL-1β) in aqueous solution : analytical methods, kinetics, products, and solution formulation implications by GU, L. C, ERDOS, E. A, HI-SHI CHIANG, CALDERWOOD, T, TSAI, K, VISOR, G. C, DUFFY, J, HSU, W.-C, FOSTER, L. C

“…The thermal stability of IL-1 beta in aqueous solution as a function of temperature (5-60 degrees C), pH (2-9), buffer (acetate, citrate, tris, and phosphate),…”
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Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys by CUNDY, K. C, FISHBACK, J. A, JENG-PYNG SHAW, LEE, M. L, SOIKE, K. F, VISOR, G. C, LEE, W. A

“…The bioavailability of PMEA from three oral formulations of the prodrug bis(POM)-PMEA has been evaluated in fasted male cynomolgus monkeys. The formulations…”
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Revisiting the Solubility Concept of Pharmaceutical Compounds by Blasko, Andrei, Leahy-Dios, Alana, Nelson, William O., Austin, Steven A., Killion, Robert B., Visor, Gary C., Massey, Ian J.

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Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs by Cundy, K C, Sue, I L, Visor, G C, Marshburn, J, Nakamura, C, Lee, W A, Shaw, J P

“…The effect of formulation on oral bioavailability of the antiviral nucleotide analogue adefovir from the prodrug adefovir dipivoxil was examined in beagle…”
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Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog by Aspe, E, Guy, R H, Lee, W A, Kennedy, J A, Visor, G C, Ennis, R D

“…The in vitro flux (4-8 h) of cidofovir (1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine) was measured across full-thickness hairless mouse skin to…”
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Characterization of metal-ion-nucleotide based particulate matter in solutions of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) by Yuan, L C, Visor, G C

“…The antiviral drug 9-[2-(phosphonomethoxy)ethyl]adenine, PMEA, was developed as an intravenous product for the treatment of human immunodeficiency virus…”
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Stability of cidofovir in 0.9% sodium chloride injection and in 5% dextrose injection by Yuan, LC, Samuels, GJ, Visor, GC

“…The stability of cidofovir in i.v. admixtures under refrigerator and room temperature conditions was studied. Admixtures of cidofovir 0.21 and 8.12 mg/mL in…”
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An unexpected pH effect on the stability of moexipril lyophilized powder by STRICKLEY, R. G, VISOR, G. C, LIN, L.-H, GU, L

“…Because of the limited stability of moexipril (RS-10085; 1) in aqueous solution, lyophilized parenteral formulations were evaluated as a function of pH in this…”
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Water soluble complexes of the antiviral drugs, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine and acyclovir: the role of hydrophobicity in complex formation by Kenley, R A, Jackson, S E, Winterle, J S, Shunko, Y, Visor, G C

“…We investigated water-soluble complexes of various ligands with the antiviral drugs, 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir) and…”
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Electrochemistry of purine derivatives. 2: Correlation of anodic differential pulse peak potentials with Hammett substituent constants by Kenley, R A, Jackson, S E, Martin, J C, Visor, G C

“…Differential pulse voltammetry was used to measure anodic peak potentials at the glassy carbon electrode (in pH 2 to 11 aqueous buffer versus Ag/AgCl) for 14…”
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Multidimensional column-switching liquid chromatographic method for dissolution testing of enprostil soft elastic gelatin capsules by Kenley, R A, Chaudhry, S, Visor, G C

“…Enprostil (methyl 7-[(1 R,2R,3R)-3-hydroxy-2-[(E)-(3R)-3-hydroxy-4- phenoxy-1-butenyl]-5-oxocyclopentyl]-4,5-heptadienoate), an E-type prostaglandin exhibiting…”
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Fluorescence immunoassay by Visor, G C, Schulman, S G

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HPLC Analysis of thimerosal in ophthalmic solution. Comparing electrochemical with spectrophotometric detectors by VISOR, G. C, KENLEY, R. A, FLEITMAN, J. S, NEU, D. A, PARTRIDGE, I. W

“…Electrochemical and spectrophotometric detectors for the reversed phase HPLC analysis of thimerosal in an ophthalmic formulation were evaluated with respect to…”
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Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections by Visor, G C, Lin, L H, Jackson, S E, Winterle, J S, Lee, G, Kenley, R A

“…The stability of 9-[(1,3-dihydroxy-2-propoxymethyl]) guanine sodium (ganciclovir sodium, also known as DHPG sodium) in two infusion solutions was studied…”
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