Search Results - "Visor, GC"

Glass Vials for Small Volume Parenterals: Influence of Drug and Manufacturing Processes on Glass Delamination by Ennis, Richard D., Pritchard, Ray, Nakamura, Carey, Coulon, Michael, Yang, Taiyin, Visor, Gary C., Lee, William A.

“…Purpose: Studies were initiated to examine the effect of formulation and process variables on the delamination process and also the influence of the glass…”
Get full text

Revisiting the Solubility Concept of Pharmaceutical Compounds by Blasko, Andrei, Leahy-Dios, Alana, Nelson, William O., Austin, Steven A., Killion, Robert B., Visor, Gary C., Massey, Ian J.

Get full text

Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs by Cundy, K C, Sue, I L, Visor, G C, Marshburn, J, Nakamura, C, Lee, W A, Shaw, J P

“…The effect of formulation on oral bioavailability of the antiviral nucleotide analogue adefovir from the prodrug adefovir dipivoxil was examined in beagle…”
Get more information

Enhanced chemical stability of the intracellular prodrug, 1-[(( S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, relative to its parent compound, cidofovir by Oliyai, Reza, Lee, William A, Visor, Gary C, Yuan, Lung-Chi

“…Degradation kinetics of cyclic HPMPC (cHPMPC), 1-[(( S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, and its parent compound cidofovir (also…”
Get full text

Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog by Aspe, E, Guy, R H, Lee, W A, Kennedy, J A, Visor, G C, Ennis, R D

“…The in vitro flux (4-8 h) of cidofovir (1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine) was measured across full-thickness hairless mouse skin to…”
Get more information

Stability of interleukin 1β (IL-1β) in aqueous solution : analytical methods, kinetics, products, and solution formulation implications by GU, L. C, ERDOS, E. A, HI-SHI CHIANG, CALDERWOOD, T, TSAI, K, VISOR, G. C, DUFFY, J, HSU, W.-C, FOSTER, L. C

“…The thermal stability of IL-1 beta in aqueous solution as a function of temperature (5-60 degrees C), pH (2-9), buffer (acetate, citrate, tris, and phosphate),…”
Get full text

Characterization of metal-ion-nucleotide based particulate matter in solutions of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) by Yuan, L C, Visor, G C

“…The antiviral drug 9-[2-(phosphonomethoxy)ethyl]adenine, PMEA, was developed as an intravenous product for the treatment of human immunodeficiency virus…”
Get more information

Stability of cidofovir in 0.9% sodium chloride injection and in 5% dextrose injection by Yuan, LC, Samuels, GJ, Visor, GC

“…The stability of cidofovir in i.v. admixtures under refrigerator and room temperature conditions was studied. Admixtures of cidofovir 0.21 and 8.12 mg/mL in…”
Get full text

An unexpected pH effect on the stability of moexipril lyophilized powder by STRICKLEY, R. G, VISOR, G. C, LIN, L.-H, GU, L

“…Because of the limited stability of moexipril (RS-10085; 1) in aqueous solution, lyophilized parenteral formulations were evaluated as a function of pH in this…”
Get full text

Intranasal delivery of nicardipine in the rat by Visor, G C, Bajka, E, Benjamin, E

“…The intranasal absorption of nicardipine hydrochloride was characterized in an in vivo rat model system in which the normal mechanisms of mucociliary clearance…”
Get more information

Water soluble complexes of the antiviral drugs, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine and acyclovir: the role of hydrophobicity in complex formation by Kenley, R A, Jackson, S E, Winterle, J S, Shunko, Y, Visor, G C

“…We investigated water-soluble complexes of various ligands with the antiviral drugs, 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir) and…”
Get more information

Electrochemistry of purine derivatives. 2: Correlation of anodic differential pulse peak potentials with Hammett substituent constants by Kenley, R A, Jackson, S E, Martin, J C, Visor, G C

“…Differential pulse voltammetry was used to measure anodic peak potentials at the glassy carbon electrode (in pH 2 to 11 aqueous buffer versus Ag/AgCl) for 14…”
Get more information

Multidimensional column-switching liquid chromatographic method for dissolution testing of enprostil soft elastic gelatin capsules by Kenley, R A, Chaudhry, S, Visor, G C

“…Enprostil (methyl 7-[(1 R,2R,3R)-3-hydroxy-2-[(E)-(3R)-3-hydroxy-4- phenoxy-1-butenyl]-5-oxocyclopentyl]-4,5-heptadienoate), an E-type prostaglandin exhibiting…”
Get more information

Electrochemistry of purine derivatives. 1: Direct determination for the antiviral drug 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine by anodic differential pulse voltammetry by Visor, G C, Jackson, S E, Kenley, R A, Lee, G C

“…Differential pulse voltammetry at a stationary glassy carbon electrode was used for the sensitive and selective analysis of a potent new antiviral analogue of…”
Get more information

Fluorescence immunoassay by Visor, G C, Schulman, S G

Get more information

HPLC Analysis of thimerosal in ophthalmic solution. Comparing electrochemical with spectrophotometric detectors by VISOR, G. C, KENLEY, R. A, FLEITMAN, J. S, NEU, D. A, PARTRIDGE, I. W

“…Electrochemical and spectrophotometric detectors for the reversed phase HPLC analysis of thimerosal in an ophthalmic formulation were evaluated with respect to…”
Get full text

Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections by Visor, G C, Lin, L H, Jackson, S E, Winterle, J S, Lee, G, Kenley, R A

“…The stability of 9-[(1,3-dihydroxy-2-propoxymethyl]) guanine sodium (ganciclovir sodium, also known as DHPG sodium) in two infusion solutions was studied…”
Get more information

Preclinical development and characterization of an intravenous dosage form for the ACE inhibitor RS-10029 by Visor, G C, Lin, L H, Henry, P, Singer, L

“…Preclinical development of an intravenous dosage form for the ACE inhibitor RS-10029 involved the formulation and characterization of the drug's…”
Get more information

Quantitative evaluation of the stability and delivery of interleukin-1B by infusion by Visor, G C, Tsai, K P, Duffy, J, Miller, M D, Calderwood, T, Knepp, V M

“…The stability and delivery of IL-1 beta has been characterized in a polypropylene based syringe pump infusion system and in polyvinyl chloride based infusion…”
Get more information

Development and characterization of a lyophilized dosage form of IL-1 beta by Visor, G C, Tsai, K P, Miller, M D, Duffy, J, Calderwood, T, Lokensgard, D, Killian, J, Malefyt, T, Gu, L, Massey, I

“…The development and characterization of a lyophilized dosage form for recombinant Interleukin-1 beta is described. Included in the evaluation of the drug…”
Get more information