Search Results - "Vishwanath, Divakar"

Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells by Vishwanath, Divakar, Xi, Zhang, Ravish, Akshay, Mohan, Arunkumar, Basappa, Shreeja, Krishnamurthy, Niranjan Pattehalli, Gaonkar, Santosh L, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Histone deacetylases (HDACs) are an attractive drug target for the treatment of human breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being…”
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Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells by Kim, Na Young, Vishwanath, Divakar, Xi, Zhang, Nagaraja, Omantheswara, Swamynayaka, Ananda, Kumar Harish, Keshav, Basappa, Shreeja, Madegowda, Mahendra, Pandey, Vijay, Sethi, Gautam, Lobie, Peter E, Ahn, Kwang Seok, Basappa, Basappa

“…Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a…”
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Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase by Vishwanath, Divakar, Girimanchanaika, Swamy S, Dukanya, Dukanya, Rangappa, Shobith, Yang, Ji-Rui, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1…”
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Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells by Kim, Na Young, Dukanya, Dukanya, Sethi, Gautam, Girimanchanaika, Swamy S, Yang, Jirui, Nagaraja, Omantheswara, Swamynayaka, Ananda, Vishwanath, Divakar, Venkantesha, Keerthikumara, Basappa, Shreeja, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Madegowda, Mahendra, Sukhorukov, Alexey, Pandey, Vijay, Lobie, Peter E., Basappa, Basappa, Ahn, Kwang Seok

“…•To overcome drug-resistant breast cancer, it is essential to develop compounds that induce apoptosis and paraptosis.•BSO-07 triggered G1 phase arrest, cleaved…”
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Electrochemical Synthesis of Versatile Pyrimidine and Oxadiazoles Tethered Triazoles as Inhibitors of VEGFR-2 in Human Breast Cancer Cells by Akshay Ravish, Tejaswini P. Siddappa, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Shreeja Basappa, Niranjan Pattehalli Krishnamurthy, Peter E. Lobie, Vijay Pandey, Basappa Basappa

“…Metastasis, the dissemination of tumor cells, stands as the second most prominent contributor to mortality arising from breast cancer. To counteract this…”
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Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF-κB in Human Breast Cancer Cells by Ravish, Akshay, Narasimhachar, Bhanuprakash C, Xi, Zhang, Vishwanath, Divakar, Mohan, Arunkumar, Gaonkar, Santosh L, Chandrashekara, Paduvalahippe Gowdegowda, Ahn, Kwang Seok, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Nuclear factor kappa B (NF-κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine- and piperazine-linked…”
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Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells by Basappa, Basappa, Poonacha, Lisha K, Xi, Zhang, Vishwanath, Divakar, Yang, Ji-Rui, Nagaraja, Omantheswara, Swamynayaka, Ananda, Madegowda, Mahendra, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Gurudatt, Doddahosuru Mahadevappa, Pandey, Vijay, Shivananju, Nanjundaswamy, Ahn, Kwang Seok, Sethi, Gautam, Lobie, Peter E, Shubha, Priya Babu

“…Small molecules are being used to inhibit cyclin dependent kinase (CDK) enzymes in cancer treatment. There is evidence that CDK is a drug-target for cancer…”
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Isoxazole based nucleosides induce autophagy through the production of ROS and the suppression of the β-catenin pathway in human colorectal carcinoma cells by Kim, Na Young, Vishwanath, Divakar, Basappa, Shreeja, Harish, Keshav Kumar, Madegowda, Mahendra, Rangappa, Kanchugarakoppal S., Basappa, Basappa, Ahn, Kwang Seok

“…β-catenin is frequently implicated in signaling pathways that regulate autophagy, and the production of reactive oxygen species (ROS) has been linked to…”
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New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis by Barash, Uri, Rangappa, Shobith, Mohan, Chakrabhavi Dhananjaya, Vishwanath, Divakar, Boyango, Ilanit, Basappa, Basappa, Vlodavsky, Israel, Rangappa, Kanchugarakoppal S.

“…Compelling evidence ties heparanase, an endoglycosidase that cleaves heparan sulfate side (HS) chains of proteoglycans, with all steps of tumor development,…”
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Discovery of Hybrid Thiouracil–Coumarin Conjugates as Potential Novel Anti-SARS-CoV‑2 Agents Targeting the Virus’s Polymerase “RdRp” as a Confirmed Interacting Biomolecule by Vishwanath, Divakar, Shete-Aich, Anita, Honnegowda, Manjunath B., Anand, Mahesh Padukudru, Chidambaram, Saravana Babu, Sapkal, Gajanan, Basappa, Basappa, Yadav, Pragya D.

“…The coronavirus (COVID-19) pandemic, along with its various strains, has emerged as a global health crisis that has severely affected humankind and posed a…”
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