Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives

Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives

In this “plastic era” with the increased use of plastic in day today's life the accumulation of its degraded products like microplastics or plastic additives such as Bisphenol A(BPA) is also increasing. BPA is an endocrine-disrupting chemical used as a plasticizing agent in clear plastic, build...

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Bibliographic Details
Published in:Environmental research Vol. 215; no. Pt 2; p. 114198
Main Authors: Sharma, Poonam, Vishwakarma, Reena, Varjani, Sunita, Gautam, Krishna, Gaur, Vivek K., Farooqui, Alvina, Sindhu, Raveendran, Binod, Parameswaran, Awasthi, Mukesh Kumar, Chaturvedi, Preeti, Pandey, Ashok
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-12-2022
Subjects:
Benzhydryl Compounds - analysis
Bioremediation
Endocrine disruptors
Endocrine Disruptors - analysis
Endocrine Disruptors - toxicity
Epoxy Resins
Microplastics
Omics-assisted remediation
Phenols
Plastic containers
Plastics
Risk Assessment
Xenobiotic remediation
Endocrine disruptors
Omics-assisted remediation
Bioremediation
Plastic containers
Xenobiotic remediation
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Summary:In this “plastic era” with the increased use of plastic in day today's life the accumulation of its degraded products like microplastics or plastic additives such as Bisphenol A(BPA) is also increasing. BPA is an endocrine-disrupting chemical used as a plasticizing agent in clear plastic, building materials, coatings, and epoxy resin. Several enzymes including laccases and lipases have been studied for the reduction of BPA toxicity. Over the decades of encountering these toxicants, microorganisms have evolved to degrade different classes of plastic additives. Since the degradation of BPA is a long process thus meta-omics approaches have been employed to identify the active microbiota and microbial dynamics involved in the mitigation of BPA. It is also necessary to investigate the impact of processing activities on transit of BPA in food items and to limit its entrance in food world. This review summarizes a comprehensive overview on BPA sources, toxicity, bio-based mitigation approaches along with a deeper understanding of multi-omics approaches for its reduction and risk analysis. Knowledge gaps and opportunities have been comprehensively compiled that would aid the state-of-the-art information in the available literature for the researchers to further address this issue.
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2022.114198