Search Results - "Vishnubalaji, Radhakrishnan"

Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling by Vishnubalaji, Radhakrishnan, Alajez, Nehad M.

“…TGFβ signaling plays crucial role during development and cancer, however the role for TGFβ signaling in regulating the noncoding part of the human genome in…”
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Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response by Vishnubalaji, Radhakrishnan, Shaath, Hibah, Alajez, Nehad M

“…The global spread of COVID-19, caused by pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for an imminent response…”
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Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19 by Shaath, Hibah, Vishnubalaji, Radhakrishnan, Elkord, Eyad, Alajez, Nehad M

“…Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity. The precise identification of immune cell subsets in bronchoalveolar…”
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Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential by Al-Nbaheen, May, Vishnubalaji, Radhakrishnan, Ali, Dalia, Bouslimi, Amel, Al-Jassir, Fawzi, Megges, Matthias, Prigione, Alessandro, Adjaye, James, Kassem, Moustapha, Aldahmash, Abdullah

“…Human stromal (mesenchymal) stem cells (hMSCs) are multipotent stem cells with ability to differentiate into mesoderm-type cells e.g. osteoblasts and…”
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Long non-coding RNA (lncRNA) transcriptional landscape in breast cancer identifies LINC01614 as non-favorable prognostic biomarker regulated by TGFβ and focal adhesion kinase (FAK) signaling by Vishnubalaji, Radhakrishnan, Shaath, Hibah, Elkord, Eyad, Alajez, Nehad M.

“…Long non-coding RNAs (lncRNAs) represent a class of epigenetic regulators implicated in a number of physiological and pathological conditions. Herein, we…”
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Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy by Shaath, Hibah, Vishnubalaji, Radhakrishnan, Elango, Ramesh, Khattak, Shahryar, Alajez, Nehad M.

“…Cumulative evidence suggests added benefit for neoadjuvant chemotherapy (NAC) in a subset of triple-negative breast cancer (TNBC) patients. Herein we…”
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Comparative investigation of the differentiation capability of bone-marrow- and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis by Vishnubalaji, Radhakrishnan, Al-Nbaheen, May, Kadalmani, Balamuthu, Aldahmash, Abdullah, Ramesh, Thiyagarajan

“…Mesenchymal stem cells (MSCs) hold promise for cell-based therapy in regenerative medicine. To date, MSCs have been obtained from conventional bone marrow via…”
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Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq by Vishnubalaji, Radhakrishnan, Alajez, Nehad M.

“…Triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy (NAC) represents a major clinical challenge; therefore, delineating tumor…”
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Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation by Vishnubalaji, Radhakrishnan, Abdel-Razeq, Hikmat, Gehani, Salahddin, Albagha, Omar M. E., Alajez, Nehad M.

“…Triple-negative breast cancer (TNBC) patients exhibiting pathological complete response (pCR) have better clinical outcomes compared to those with residual…”
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Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells by Alsalhi, Mohamad S, Devanesan, Sandhanasamy, Alfuraydi, Akram A, Vishnubalaji, Radhakrishnan, Munusamy, Murugan A, Murugan, Kadarkarai, Nicoletti, Marcello, Benelli, Giovanni

“…The present study focused on a simple and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) with multipurpose anticancer and antimicrobial…”
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Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes by Vishnubalaji, Radhakrishnan, Alajez, Nehad M

“…Breast cancer (BC) is a heterogeneous disease, which is primarily classified according to hormone receptors and HER2 expression. Despite the many advances in…”
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Integrated Transcriptome and Pathway Analyses Revealed Multiple Activated Pathways in Breast Cancer by Vishnubalaji, Radhakrishnan, Sasidharan Nair, Varun, Ouararhni, Khalid, Elkord, Eyad, Alajez, Nehad M.

“…Breast cancer (BC) is the leading cause of cancer-related death in women. Therefore, a better understanding of BC biology and signaling pathways might lead to…”
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Long non-coding RNA AC099850.4 correlates with advanced disease state and predicts worse prognosis in triple-negative breast cancer by Vishnubalaji, Radhakrishnan, Alajez, Nehad M.

“…Our understanding of the function of long non-coding RNAs (lncRNAs) in health and disease states has evolved over the past decades due to the many advances in…”
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Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent manner by Elsafadi, Mona, Manikandan, Muthurangan, Almalki, Sami, Mahmood, Amer, Shinwari, Tasneem, Vishnubalaji, Radhakrishnan, Mobarak, Mohammad, Alfayez, Musaad, Aldahmash, Abdullah, Kassem, Moustapha, Alajez, Nehad M.

“…Colorectal cancer (CRC) is the fourth most common cancer type globally. Investigating the signaling pathways that maintain cancer cell phenotype can identify…”
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MicroRNAome profiling of breast cancer unveils hsa-miR-5683 as a tumor suppressor microRNA predicting favorable clinical outcome by Abohalawa, Bushra Yasin, Shaath, Hibah, Elango, Ramesh, Vishnubalaji, Radhakrishnan, Rashid, Sameera, Al-Sarraf, Reem, Akhtar, Mohammed, Alajez, Nehad M.

“…Breast cancer is a heterogeneous disease with diverse molecular subtypes, underscoring a better understanding of its molecular features and underlying…”
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Therapeutic targeting of the TPX2/TTK network in colorectal cancer by Shaath, Hibah, Vishnubalaji, Radhakrishnan, Elango, Ramesh, Velayutham, Dinesh, Jithesh, Puthen Veettil, Alajez, Nehad M

“…While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic…”
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Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition by Elango, Ramesh, Vishnubalaji, Radhakrishnan, Shaath, Hibah, Alajez, Nehad M.

“…Background DNA methylation plays a crucial role in multiple cellular processes such as gene regulation, chromatin stability, and genetic imprinting. In…”
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Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxel by Elango, Ramesh, Vishnubalaji, Radhakrishnan, Shaath, Hibah, Alajez, Nehad M.

“…Triple-negative breast cancer (TNBC) patients exhibit variable responses to chemotherapy, suggesting an underlying molecular heterogeneity. In the current…”
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Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B by Vishnubalaji, Radhakrishnan, Elango, Ramesh, Al-Toub, Mashael, Manikandan, Muthurangan, Al-Rikabi, Ammar, Harkness, Linda, Ditzel, Nicholas, Atteya, Muhammad, Hamam, Rimi, Alfayez, Musaad, Aldahmash, Abdullah, Kassem, Moustapha, Alajez, Nehad M.

“…Bone marrow stromal (Mesenchymal) stem cells (MSCs) are multipotent bone cells capable of differentiating into mesoderm-type cells, such as osteoblasts and…”
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Transcriptome profiling and network enrichment analyses identify subtype-specific therapeutic gene targets for breast cancer and their microRNA regulatory networks by Elango, Ramesh, Rashid, Sameera, Vishnubalaji, Radhakrishnan, Al-Sarraf, Reem, Akhtar, Mohammed, Ouararhni, Khalid, Decock, Julie, Albagha, Omar M. E., Alajez, Nehad M.

“…Previous studies have suggested that breast cancer (BC) from the Middle East and North Africa (MENA) is presented at younger age with advanced tumor stage,…”
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