Search Results - "Vishnivetskiy, Sergey A"

Structural basis of arrestin-3 activation and signaling by Chen, Qiuyan, Perry, Nicole A., Vishnivetskiy, Sergey A., Berndt, Sandra, Gilbert, Nathaniel C., Zhuo, Ya, Singh, Prashant K., Tholen, Jonas, Ohi, Melanie D., Gurevich, Eugenia V., Brautigam, Chad A., Klug, Candice S., Gurevich, Vsevolod V., Iverson, T. M.

“…A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol…”
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Structural Basis of Arrestin Selectivity for Active Phosphorylated G Protein-Coupled Receptors by Karnam, Preethi C, Vishnivetskiy, Sergey A, Gurevich, Vsevolod V

“…Arrestins are a small family of proteins that bind G protein-coupled receptors (GPCRs). Arrestin binds to active phosphorylated GPCRs with higher affinity than…”
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Identification of Receptor Binding-induced Conformational Changes in Non-visual Arrestins by Zhuo, Ya, Vishnivetskiy, Sergey A., Zhan, Xuanzhi, Gurevich, Vsevolod V., Klug, Candice S.

“…The non-visual arrestins, arrestin-2 and arrestin-3, belong to a small family of multifunctional cytosolic proteins. Non-visual arrestins interact with…”
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Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin by Zhuang, Tiandi, Chen, Qiuyan, Cho, Min-Kyu, Vishnivetskiy, Sergey A., Iverson, Tina M., Gurevich, Vsevolod V., Sanders, Charles R.

“…Solution NMR spectroscopy of labeled arrestin-1 was used to explore its interactions with dark-state phosphorylated rhodopsin (P-Rh), phosphorylated opsin…”
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G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs) by Li, Lingyong, Homan, Kristoff T., Vishnivetskiy, Sergey A., Manglik, Aashish, Tesmer, John J.G., Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in homologous desensitization of GPCRs. It is widely assumed that most GRKs selectively…”
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An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins by Chen, Qiuyan, Zhuo, Ya, Sharma, Pankaj, Perez, Ivette, Francis, Derek J., Chakravarthy, Srinivas, Vishnivetskiy, Sergey A., Berndt, Sandra, Hanson, Susan M., Zhan, Xuanzhi, Brooks, Evan K., Altenbach, Christian, Hubbell, Wayne L., Klug, Candice S., Iverson, T.M., Gurevich, Vsevolod V.

“…[Display omitted] •In the presence of IP6 arrestin-2 and arrestin-3 form different oligomers.•IP6 activates arrestin-3, but does not activate arrestin-2.•An…”
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Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding by Bayburt, Timothy H., Vishnivetskiy, Sergey A., McLean, Mark A., Morizumi, Takefumi, Huang, Chih-chin, Tesmer, John J.G., Ernst, Oliver P., Sligar, Stephen G., Gurevich, Vsevolod V.

“…G-protein-coupled receptor (GPCR) oligomerization has been observed in a wide variety of experimental contexts, but the functional significance of this…”
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Functional Role of Arrestin-1 Residues Interacting with Unphosphorylated Rhodopsin Elements by Vishnivetskiy, Sergey A, Weinstein, Liana D, Zheng, Chen, Gurevich, Eugenia V, Gurevich, Vsevolod V

“…Arrestin-1, or visual arrestin, exhibits an exquisite selectivity for light-activated phosphorylated rhodopsin (P-Rh*) over its other functional forms. That…”
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The Role of Arrestin-1 Middle Loop in Rhodopsin Binding by Vishnivetskiy, Sergey A, Huh, Elizabeth K, Karnam, Preethi C, Oviedo, Samantha, Gurevich, Eugenia V, Gurevich, Vsevolod V

“…Arrestins preferentially bind active phosphorylated G protein-coupled receptors (GPCRs). The middle loop, highly conserved in all arrestin subtypes, is…”
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Manipulation of Very Few Receptor Discriminator Residues Greatly Enhances Receptor Specificity of Non-visual Arrestins by Gimenez, Luis E., Vishnivetskiy, Sergey A., Baameur, Faiza, Gurevich, Vsevolod V.

“…Based on the identification of residues that determine receptor selectivity of arrestins and the analysis of the evolution in the arrestin family, we…”
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Biological Role of Arrestin-1 Oligomerization by Samaranayake, Srimal, Vishnivetskiy, Sergey A, Shores, Camilla R, Thibeault, Kimberly C, Kook, Seunghyi, Chen, Jeannie, Burns, Marie E, Gurevich, Eugenia V, Gurevich, Vsevolod V

“…Members of the arrestin superfamily have great propensity of self-association, but the physiological significance of this phenomenon is unclear. To determine…”
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Conformation of receptor-bound visual arrestin by Kim, Miyeon, Vishnivetskiy, Sergey A, Van Eps, Ned, Alexander, Nathan S, Cleghorn, Whitney M, Zhan, Xuanzhi, Hanson, Susan M, Morizumi, Takefumi, Ernst, Oliver P, Meiler, Jens, Gurevich, Vsevolod V, Hubbell, Wayne L

“…Arrestin-1 (visual arrestin) binds to light-activated phosphorylated rhodopsin (P-Rh*) to terminate G-protein signaling. To map conformational changes upon…”
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Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice by Meister, Jaroslawna, Bone, Derek B J, Godlewski, Grzegorz, Liu, Ziyi, Lee, Regina J, Vishnivetskiy, Sergey A, Gurevich, Vsevolod V, Springer, Danielle, Kunos, George, Wess, Jürgen

“…Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New…”
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Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains by Zhan, Xuanzhi, Perez, Alejandro, Gimenez, Luis E., Vishnivetskiy, Sergey A., Gurevich, Vsevolod V.

“…Although arrestins bind dozens of non-receptor partners, the interaction sites for most signaling proteins remain unknown. Here we report the identification of…”
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G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro by Inagaki, Sayaka, Ghirlando, Rodolfo, Vishnivetskiy, Sergey A, Homan, Kristoff T, White, Jim F, Tesmer, John J. G, Gurevich, Vsevolod V, Grisshammer, Reinhard

“…G protein-coupled receptor kinases (GRKs) play an important role in the desensitization of G protein-mediated signaling of G protein-coupled receptors (GPCRs)…”
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The functional cycle of visual arrestins in photoreceptor cells by Gurevich, Vsevolod V., Hanson, Susan M., Song, Xiufeng, Vishnivetskiy, Sergey A., Gurevich, Eugenia V.

“…Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. Its highly selective binding to light-activated phosphorylated…”
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Role of Receptor-attached Phosphates in Binding of Visual and Non-visual Arrestins to G Protein-coupled Receptors by Gimenez, Luis E., Kook, Seunghyi, Vishnivetskiy, Sergey A., Ahmed, M. Rafiuddin, Gurevich, Eugenia V., Gurevich, Vsevolod V.

“…Arrestins are a small family of proteins that regulate G protein-coupled receptors (GPCRs). Arrestins specifically bind to phosphorylated active receptors,…”
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Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors by Prokop, Susanne, Perry, Nicole A., Vishnivetskiy, Sergey A., Toth, Andras D., Inoue, Asuka, Milligan, Graeme, Iverson, Tina M., Hunyady, Laszlo, Gurevich, Vsevolod V.

“…Non-visual arrestins interact with hundreds of different G protein-coupled receptors (GPCRs). Here we show that by introducing mutations into elements that…”
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Regulation of Arrestin Binding by Rhodopsin Phosphorylation Level by Vishnivetskiy, Sergey A., Raman, Dayanidhi, Wei, Junhua, Kennedy, Matthew J., Hurley, James B., Gurevich, Vsevolod V.

“…Arrestins ensure the timely termination of receptor signaling. The role of rhodopsin phosphorylation in visual arrestin binding was established more than 20…”
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Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1 by Samaranayake, Srimal, Song, Xiufeng, Vishnivetskiy, Sergey A, Chen, Jeannie, Gurevich, Eugenia V, Gurevich, Vsevolod V

“…We determined the effects of different expression levels of arrestin-1-3A mutant with enhanced binding to light-activated rhodopsin that is independent of…”
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