Search Results - "Viscusi, John"

A Phase 1 Dose Escalation Study of Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Patients with Myeloid Malignancies by Patel, Manish R., Monga, Varun, Jauhari, Shekeab, Stevens, Don, Masarova, Lucia, McKean, Meredith, Mauro, David, Viscusi, John, Scherle, Peggy, Bhagwat, Neha, Moore, Andrew, Sun, William, Chiaverelli, Rachel, Mintah, Eric, Nath, Rajneesh, Stein, Eytan M., Palmisiano, Neil, Sutamtewagul, Grerk, Verstovsek, Srdan

“…Background: PRMT5 is overexpressed in certain myeloid malignancies and catalyzes symmetric arginine dimethylation of protein substrates that regulate…”
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Abstract P039: A phase 1 dose escalation study of protein arginine methyltransferase 5 (PRMT5) inhibitor PRT543 in patients with advanced solid tumors and lymphoma by McKean, Meredith, Patel, Manish R., Wesolowski, Robert, Ferrarotto, Renata, Stein, Eytan M., Shoushtari, Alexander N., Mauro, David, Viscusi, John, Scherle, Peggy, Bhagwat, Neha, Sun, William, Chiaverelli, Rachel, Mintah, Eric, Jauhari, Shekeab, Finn, Laura, Palmisiano, Neil D., Baiocchi, Robert A.

“…Abstract Background: PRMT5 catalyzes symmetric arginine dimethylation of protein substrates with important roles in cancer cell growth/survival. PRT543 is a…”
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Abstract P044: A phase 1 dose escalation study of protein arginine methyltransferase 5 (PRMT5) brain penetrant inhibitor PRT811 in patients with advanced solid tumors, including recurrent high-grade gliomas by Falchook, Gerald S., Glass, Jon, Monga, Varun, Giglio, Pierre, Mauro, David, Viscusi, John, Scherle, Peggy, Bhagwat, Neha, Sun, William, Chiaverelli, Rachel, Mintah, Eric, Clements, Lydia, Johanns, Tanner M., McKean, Meredith

“…Abstract Background: PRMT5 catalyzes symmetric arginine dimethylation of protein substrates with important roles in cancer cell growth/survival, including…”
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1141-198 Etoricoxib has no adverse effects on biomarkers of cardiovascular risk in patients with osteoarthritis by DiBattiste, Peter M, Chen, Cong, Viscusi, John, Curtis, Sean P, Cannon, Christopher P

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A Comparison of Cardiovascular Biomarkers in Patients Treated for Three Months with Etoricoxib, Celecoxib, Ibuprofen, and Placebo by Cannon, Christopher P., Chen, Cong, Curtis, Sean P., Viscusi, John, Ahmed, Tuli, DiBattiste, Peter M.

“…ABSTRACT Objectives.  Selective cyclooxygenase (COX)‐2 inhibitors are effective analgesic and anti‐inflammatory agents with improved gastrointestinal safety…”
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Effects of losartan vs. captopril on aldosterone and sodium retention score in elderly symptomatic heart failure patients — elite raas substudy by Segal, Robert, Ikeda, Leila, Klinger, George, Viscusi, John, Preston, Peter, Sharma, Divakar, Pitt, Bertram, Cody, Robert, for the ELITE Investigators

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Regulation through Litigation by Viscusi, Kip W

“…Recent high-profile lawsuits involving cigarettes, guns, breast implants, and other products have created new frictions between litigation and regulation…”
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