Influence of the −675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden

Elevated plasminogen activator inhibitor 1 (PAI‐1) levels are associated with venous thromboembolism, although their significance is unclear. PAI‐1 levels are influenced by a PAI‐1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI‐1 activity. We investigated whether the...

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Bibliographic Details
Published in:	British journal of haematology Vol. 110; no. 1; pp. 135 - 138
Main Authors:	Visanji, J. M., Seargent, J., Tahri, D., Croft, S. A., Makris, M., Preston, F. E., Peake, I. R., Daly, M. E.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-07-2000 Blackwell Blackwell Publishing Ltd
Subjects:	4G/5G Adult Age of Onset Aged Alleles Biological and medical sciences Case-Control Studies Chi-Square Distribution Confidence Intervals dimorphism Factor V Female Genotype Hematologic and hematopoietic diseases Hematology Humans Male Medical sciences Middle Aged Odds Ratio PAI‐1 Plasminogen Activator Inhibitor 1 - genetics Platelet diseases and coagulopathies Polymorphism, Genetic Risk thromboembolism Thrombophilia - blood Thrombophilia - genetics venous Human Factor V Leiden Transcription promoter Cardiovascular disease Dimorphism Thrombosis Vascular disease Plasminogen activator inhibitor 1 Gene Risk factor Genetics Thromboembolism Coagulopathy
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Summary:	Elevated plasminogen activator inhibitor 1 (PAI‐1) levels are associated with venous thromboembolism, although their significance is unclear. PAI‐1 levels are influenced by a PAI‐1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI‐1 activity. We investigated whether the 4G allele influenced thrombotic risk by studying 99 symptomatic factor V (FV) Leiden heterozygotes and 99 healthy subjects. The 4G allele was more prevalent among cases than among healthy subjects (χ2 = 8·00, P = 0·005) and the odds ratio (OR) for thrombosis associated with either heterozygosity or homozygosity for the 4G allele was 2·43 (P = 0·011). We conclude that carriership of the 4G allele was more prevalent in patients who already carried factor V Leiden than in control subjects without factor V Leiden.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.2000.02152.x