Search Results - "Visakorpi, T."

Changes in circulating microRNA levels associated with prostate cancer by Bryant, R J, Pawlowski, T, Catto, J W F, Marsden, G, Vessella, R L, Rhees, B, Kuslich, C, Visakorpi, T, Hamdy, F C

“…Background: The aim of this study was to investigate the hypothesis that changes in circulating microRNAs (miRs) represent potentially useful biomarkers for…”
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Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer by Martens-Uzunova, E S, Jalava, S E, Dits, N F, van Leenders, G J L H, Møller, S, Trapman, J, Bangma, C H, Litman, T, Visakorpi, T, Jenster, G

“…Prostate cancer (PCa) is the most frequent male malignancy and the second most common cause of cancer-related death in Western countries. Current clinical and…”
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Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy by Woodcock, D. J., Riabchenko, E., Taavitsainen, S., Kankainen, M., Gundem, G., Brewer, D. S., Ellonen, P., Lepistö, M., Golubeva, Y. A., Warner, A. C., Tolonen, T., Jasu, J., Isaacs, W. B., Emmert-Buck, M. R., Nykter, M., Visakorpi, T., Bova, G. S., Wedge, D. C.

“…The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer…”
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Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer by Urbanucci, A, Sahu, B, Seppälä, J, Larjo, A, Latonen, L M, Waltering, K K, Tammela, T L J, Vessella, R L, Lähdesmäki, H, Jänne, O A, Visakorpi, T

“…Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression…”
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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse by Taavitsainen, S., Engedal, N., Cao, S., Handle, F., Erickson, A., Prekovic, S., Wetterskog, D., Tolonen, T., Vuorinen, E. M., Kiviaho, A., Nätkin, R., Häkkinen, T., Devlies, W., Henttinen, S., Kaarijärvi, R., Lahnalampi, M., Kaljunen, H., Nowakowska, K., Syvälä, H., Bläuer, M., Cremaschi, P., Claessens, F., Visakorpi, T., Tammela, T. L. J., Murtola, T., Granberg, K. J., Lamb, A. D., Ketola, K., Mills, I. G., Attard, G., Wang, W., Nykter, M., Urbanucci, A.

“…Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ…”
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Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer by Jalava, S E, Urbanucci, A, Latonen, L, Waltering, K K, Sahu, B, Jänne, O A, Seppälä, J, Lähdesmäki, H, Tammela, T L J, Visakorpi, T

“…The androgen receptor (AR) signaling pathway is involved in the emergence of castration-resistant prostate cancer (CRPC). Here, we identified several…”
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Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies by Veskimäe, K, Scaravilli, M, Niininen, W, Karvonen, H, Jaatinen, S, Nykter, M, Visakorpi, T, Mäenpää, J, Ungureanu, D, Staff, S

“…Ovarian cancer has the highest mortality rate of all gynecologic malignancies. Identification of new biomarkers is highly needed due to its late diagnosis and…”
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The expression of SOCS is altered in rheumatoid arthritis by Isomäki, P., Alanärä, T., Isohanni, P., Lagerstedt, A., Korpela, M., Moilanen, T., Visakorpi, T., Silvennoinen, O.

“…Objectives. Cytokines play a key pathogenic role in rheumatoid arthritis (RA). Several cytokines signal through the JAK-STAT pathway, which is negatively…”
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2519 Role of miR-32 in prostate cancer by Latonen, L, Saravilli, M, Zhang, F, Ruusuvuori, P, Poutanen, M, Visakorpi, T

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Tumor features and survival after radical prostatectomy among antidiabetic drug users by Joentausta, R M, Kujala, P M, Visakorpi, T, Tammela, T L J, Murtola, T J

“…Background: To evaluate the association between use of metformin and other antidiabetic drugs with tumor characteristics and survival in surgically managed…”
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Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers by GEORGITSI, M, KARHU, A, WINQVIST, R, VISAKORPI, T, WALTERING, K, VAHTERISTO, P, LAUNONEN, V, AALTONEN, L. A

“…Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene were recently identified in individuals with pituitary adenoma…”
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miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression by Zoni, E, van der Horst, G, van de Merbel, A F, Chen, L, Rane, J K, Pelger, R C M, Collins, A T, Visakorpi, T, Snaar-Jagalska, B E, Maitland, N J, van der Pluijm, G

“…Altered microRNA (miRNA; miR) expression is associated with tumor formation and progression of various solid cancers. A major challenge in miRNA expression…”
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20 miR-25 is a key regulator of prostate cancer invasiveness by modulation of the cross-talk between Notch and TGF-β signaling by Zoni, E, van de Merbel, A.F, van der Horst, G, Rane, J, Visakorpi, T, Snaar, E.B, Maitland, N, van der Pluijm, G

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Androgen receptor gene and hormonal therapy failure of prostate cancer by Koivisto, P, Kolmer, M, Visakorpi, T, Kallioniemi, OP

“…Androgen receptor (AR) is a nuclear transcription factor that binds male sex steroids and mediates the biological effects of these hormones to the target…”
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12: Proffered Paper: The life history of lethal metastatic prostate cancer (The UK prostate cancer working group of the International Cancer Genome Consortium) by Wedge, D.C, Gundem, G, Van Loo, P, Brewer, D, Leinonen, K, Eeles, R, Cooper, C, Visakorpi, T, McDermott, U, Bova, G.S

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Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells by Makkonen, H, Jääskeläinen, T, Pitkänen-Arsiola, T, Rytinki, M, Waltering, K K, Mättö, M, Visakorpi, T, Palvimo, J J

“…Transcriptional control by androgens via androgen receptor (AR) is strongly involved in prostate cancer development, but the critical target genes have…”
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The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth by BERNARD, D, GIL, J, DUMONT, P, RIZZO, S, MONTI, D, QUATANNENS, B, HUDSON, D, VISAKORPI, T, FUKS, F, DE LAUNOIT, Y

“…The incidence of prostate cancer is increasing in western countries because of population aging. Prostate cancer begins as an androgen-dependent disease, but…”
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Amplification of EIF3S3 Gene Is Associated with Advanced Stage in Prostate Cancer by Saramäki, Outi, Willi, Niels, Bratt, Ola, Gasser, Thomas C., Koivisto, Pasi, Nupponen, Nina N., Bubendorf, Lukas, Visakorpi, Tapio

“…Gain of the long arm of chromosome 8 (8q) is one of the most common gains found in the advanced prostate cancer by comparative genomic hybridization. We have…”
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Overexpression and gene amplification of BAG-IL in hormone-refractory prostate cancer by MÄKI, H. E, SARAMÄKI, O. R, SHATKINA, L, MARTIKAINEN, P. M, TAMMELA, T. L. J, VAN WEERDEN, W. M, VESSELLA, R. L, CATO, A. C. B, VISAKORPI, T

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Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation by Visakorpi, T, Kallioniemi, O P, Heikkinen, A, Koivula, T, Isola, J

“…Mutations in the p53 gene resulting in the accumulation of altered p53 proteins with prolonged half-life have been found in a large variety of human…”
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