Search Results - "Virus Research"

COVID-19 Vaccine: A comprehensive status report by Kaur, Simran Preet, Gupta, Vandana

“…•Platforms for COVID-19 vaccine development.•Clinical Trials in COVID-19 and their results.•Use of preformed antibodies.•Vaccine development and its…”
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Gut microbiota and Covid-19- possible link and implications by Dhar, Debojyoti, Mohanty, Abhishek

“…•Covid-19 disease show gastrointestinal symptoms in some patients hinting at a role of gut-lung axis.•Gut microbiota diversity and its role in immunity…”
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Co-infection with respiratory pathogens among COVID-2019 cases by Zhu, Xiaojuan, Ge, Yiyue, Wu, Tao, Zhao, Kangchen, Chen, Yin, Wu, Bin, Zhu, Fengcai, Zhu, Baoli, Cui, Lunbiao

“…•We describe the presence of 24 respiratory pathogens as co-infections in COVID-19 patients.•Most of these co-infections occurred 1–4 days after the onset of…”
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Natural product-derived phytochemicals as potential agents against coronaviruses: A review by Mani, Janice S., Johnson, Joel B., Steel, Jason C., Broszczak, Daniel A., Neilsen, Paul M., Walsh, Kerry B., Naiker, Mani

“…[Display omitted] •Naturally derived compounds provide a potential wealth of antiviral agents.•We reviewed the literature on phytochemicals against different…”
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The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway by Li, Jin-Yan, Liao, Ce-Heng, Wang, Qiong, Tan, Yong-Jun, Luo, Rui, Qiu, Ye, Ge, Xing-Yi

“…•ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 strongly inhibited type I interferon (IFN-β) activation and NF-κB pathway.•ORF6 and ORF8, but not…”
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iSCAN: An RT-LAMP-coupled CRISPR-Cas12 module for rapid, sensitive detection of SARS-CoV-2 by Ali, Zahir, Aman, Rashid, Mahas, Ahmed, Rao, Gundra Sivakrishna, Tehseen, Muhammad, Marsic, Tin, Salunke, Rahul, Subudhi, Amit K., Hala, Sharif M., Hamdan, Samir M., Pain, Arnab, Alofi, Fadwa S., Alsomali, Afrah, Hashem, Anwar M., Khogeer, Asim, Almontashiri, Naif A.M., Abedalthagafi, Malak, Hassan, Norhan, Mahfouz, Magdy M.

“…•RT-LAMP coupled with CRISPR-Cas12 provides a sensitive and specific virus detection platform.•iSCAN sensitivity and specificity are comparable with…”
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Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control by Jung, Kwonil, Saif, Linda J., Wang, Qiuhong

“…•Porcine epidemic diarrhea virus (PEDV) causes acute diarrhea, dehydration and high mortality in neonatal pig.•S INDEL and non-S INDEL strains were detected…”
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African swine fever – A review of current knowledge by Blome, Sandra, Franzke, Kati, Beer, Martin

“…•African swine fever emerged in several European and Asian countries.•Review of current knowledge of African swine fever (ASF).•Focus on ASF virology, clinical…”
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Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis by Millet, Jean Kaoru, Whittaker, Gary R.

“…•Coronavirus spike proteins can be cleaved by a multitude of host cell proteases.•Proteolytic activation of spike is a crucial step to activate its…”
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IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection by Gadotti, Ana Carolina, de Castro Deus, Marina, Telles, Joao Paulo, Wind, Rafael, Goes, Marina, Garcia Charello Ossoski, Roberta, de Padua, Alessandra Michalski, de Noronha, Lucia, Moreno-Amaral, Andrea, Baena, Cristina Pellegrino, Tuon, Felipe Francisco

“…•Inflammatory innate immunity can be described as prognostic factors.•The balancing between Th1 and Th2 response can be associated with mortality in patients…”
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Porcine circoviruses: current status, knowledge gaps and challenges by Opriessnig, Tanja, Karuppannan, Anbu K., Castro, Alessandra M.M.G., Xiao, Chao-Ting

“…•Porcine circoviruses (PCVs) are widespread and expanding.•The pathogenic potential and impact on pig production is different for each PCV.•Current knowledge…”
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Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63 by Weng, Jing-Ru, Lin, Chen-Sheng, Lai, Hsueh-Chou, Lin, Yu-Ping, Wang, Ching-Ying, Tsai, Yu-Chi, Wu, Kun-Chang, Huang, Su-Hua, Lin, Cheng-Wen

“…•Sambucus FormosanaNakai extract reduced cytopathicity and virus yield in HCoV-NL63-infected cells.•Among phenolic acid constituents, caffeic acid, chlorogenic…”
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Classical swine fever virus: the past, present and future by Ganges, Llilianne, Crooke, Helen R., Bohórquez, Jose Alejandro, Postel, Alexander, Sakoda, Yoshihiro, Becher, Paul, Ruggli, Nicolas

“…•A comprehensive overview of the recent advances in fundamental CSFV research.•Recent advances in diagnostics and vaccine development.•Genetic diversity of…”
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Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19 by Kumar, Raman, Rathi, Himani, Haq, Afrozul, Wimalawansa, Sunil J., Sharma, Alpana

“…•COVID-19 is a global pandemic caused due to SARS-CoV-2.•Etiopathogenesis of SARS-CoV-2 in severe and critical COVID-19 cases showed exaggerated immune…”
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Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development by Samrat, Subodh Kumar, Tharappel, Anil M., Li, Zhong, Li, Hongmin

“…•SARS-CoV-2 binds more strongly to ACE2 as compare to SARS-CoV.•The viral Spike protein is most important target for vaccine design.•Antibody dependent…”
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The structure and functions of coronavirus genomic 3′ and 5′ ends by Yang, Dong, Leibowitz, Julian L.

“…•Models of conserved 5′ and 3′ betacoronavirus cis-acting RNA secondary structures are presented.•The 5′ cis-acting sequences required for coronavirus…”
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The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta by Rashid, Farooq, Dzakah, Emmanuel Enoch, Wang, Haiying, Tang, Shixing

“…•SARS-CoV-2 orf8 genotypes, orf8L and orf8S induced ER stress pathways.•SARS-CoV-2 orf8 genotypes, orf8L and orf8S antagonized interferon Beta…”
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Pervasive transmission of E484K and emergence of VUI-NP13L with evidence of SARS-CoV-2 co-infection events by two different lineages in Rio Grande do Sul, Brazil by Francisco Jr, Ronaldo da Silva, Benites, L. Felipe, Lamarca, Alessandra P., de Almeida, Luiz G.P., Hansen, Alana Witt, Gularte, Juliana Schons, Demoliner, Meriane, Gerber, Alexandra L., de C Guimarães, Ana Paula, Antunes, Ana Karolina Eisen, Heldt, Fagner Henrique, Mallmann, Larissa, Hermann, Bruna, Ziulkoski, Ana Luiza, Goes, Vyctoria, Schallenberger, Karoline, Fillipi, Micheli, Pereira, Francini, Weber, Matheus Nunes, de Almeida, Paula Rodrigues, Fleck, Juliane Deise, Vasconcelos, Ana Tereza R., Spilki, Fernando Rosado

“…•The novel variant B.1.1.28 (E484 K) previously described in Rio de Janeiro is currently spread across the southernmost state of Brazil.•The novel variant…”
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Immunological co-ordination between gut and lungs in SARS-CoV-2 infection by Ahlawat, Shruti, Asha, Sharma, Krishna Kant

“…•SARS-CoV-2 is currently causing a major pandemic called COVID-19.•SARS-CoV-2 affects almost any organ due to the presence of ACE2 receptor.•Immunological…”
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Porcine epidemic diarrhea in China by Wang, Dang, Fang, Liurong, Xiao, Shaobo

“…•Porcine epidemic diarrhea (PED) has become a major threat to the pig farming industry in China.•Epidemic PEDV variants tend to be more pathogenic and cause a…”
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