Search Results - "Virtanen, Salla I"

Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening by Virtanen, Salla I., Niinivehmas, Sanna P., Pentikäinen, Olli T.

“…[Display omitted] •The results show significant differences between the different implicit water models.•Performance of different implicit water models is…”
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The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms by Beyer, Hannes M, Virtanen, Salla I, Aranko, A Sesilja, Mikula, Kornelia M, Lountos, George T, Wlodawer, Alexander, Ollila, O H Samuli, Iwaï, Hideo

“…Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes…”
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Inverse Conformational Selection in Lipid–Protein Binding by Bacle, Amélie, Buslaev, Pavel, Garcia-Fandino, Rebeca, Favela-Rosales, Fernando, Mendes Ferreira, Tiago, Fuchs, Patrick F. J, Gushchin, Ivan, Javanainen, Matti, Kiirikki, Anne M, Madsen, Jesper J, Melcr, Josef, Milán Rodríguez, Paula, Miettinen, Markus S, Ollila, O. H. Samuli, Papadopoulos, Chris G, Peón, Antonio, Piggot, Thomas J, Piñeiro, Ángel, Virtanen, Salla I

“…Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology…”
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Heterogeneous dynamics in partially disordered proteins by Virtanen, Salla I, Kiirikki, Anne M, Mikula, Kornelia M, Iwaï, Hideo, Ollila, O H Samuli

“…Importance of disordered protein regions is increasingly recognized in biology, but their characterization remains challenging due to the lack of suitable…”
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Efficient Virtual Screening Using Multiple Protein Conformations Described as Negative Images of the Ligand-Binding Site by Virtanen, Salla I, Pentikäinen, Olli T

“…The protein structure-based virtual screening is typically accomplished using a molecular docking procedure. However, docking is a fairly slow process that is…”
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Comparison of Virtual High-Throughput Screening Methods for the Identification of Phosphodiesterase-5 Inhibitors by Niinivehmas, Sanna P, Virtanen, Salla I, Lehtonen, Jukka V, Postila, Pekka A, Pentikäinen, Olli T

“…Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects…”
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Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression by Hughes, Travis S., Langer, Stephen J., Virtanen, Salla I., Chavez, Raymond A., Watkins, Linda R., Milligan, Erin D., Leinwand, Leslie A.

“…Background One method for the delivery of therapeutic proteins to the spinal cord is to inject nonviral gene vectors including plasmid DNA into the…”
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