Search Results - "Virginia M.-Y. Lee"

Protein transmission in neurodegenerative disease by Peng, Chao, Trojanowski, John Q., Lee, Virginia M.-Y.

“…Most neurodegenerative diseases are characterized by the intracellular or extracellular aggregation of misfolded proteins such as amyloid-β and tau in…”
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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases by Guo, Jing L, Lee, Virginia M Y

“…Numerous neurodegenerative diseases show deposition of protein aggregates, which are thought to cause neuronal damage. This Review discusses how cell-to-cell…”
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Spreading of pathology in neurodegenerative diseases: a focus on human studies by Brettschneider, Johannes, Tredici, Kelly Del, Lee, Virginia M.-Y., Trojanowski, John Q.

“…Key Points Many neurodegenerative diseases share a common pathological hallmark: the accumulation of characteristic proteins into insoluble aggregates in…”
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Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies by Irwin, David J., Lee, Virginia M.-Y., Trojanowski, John Q.

“…Key Points Notable heterogeneity exists in the neuropathological substrates that underlie dementia in the setting of Parkinson's disease dementia (PDD)…”
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Stages of pTDP-43 pathology in amyotrophic lateral sclerosis by Brettschneider, Johannes, Del Tredici, Kelly, Toledo, Jon B., Robinson, John L., Irwin, David J., Grossman, Murray, Suh, EunRan, Van Deerlin, Vivianna M., Wood, Elisabeth M., Baek, Young, Kwong, Linda, Lee, Edward B., Elman, Lauren, McCluskey, Leo, Fang, Lubin, Feldengut, Simone, Ludolph, Albert C., Lee, Virginia M.-Y., Braak, Heiko, Trojanowski, John Q.

“…Objective To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral…”
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Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles by Guo, Jing L., Lee, Virginia M.-Y.

“…Neurofibrillary tangles (NFTs) in Alzheimer disease and related tauopathies are composed of insoluble hyperphosphorylated Tau protein, but the mechanisms…”
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Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy by Spiller, Krista J., Restrepo, Clark R., Khan, Tahiyana, Dominique, Myrna A., Fang, Terry C., Canter, Rebecca G., Roberts, Christopher J., Miller, Kelly R., Ransohoff, Richard M., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8…”
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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders by Trojanowski, John Q, Ballatore, Carlo, Lee, Virginia M.-Y

“…Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in Alzheimer's disease (AD) and related tauopathies, which are characterized…”
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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice by Luk, Kelvin C., Kehm, Victoria, Carroll, Jenna, Zhang, Bin, O'Brien, Patrick, Trojanowski, John Q., Lee, Virginia M.-Y.

“…Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions, known as Lewy bodies and Lewy neurites, and the massive loss of…”
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Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects by Shaw, Leslie M., Vanderstichele, Hugo, Knapik-Czajka, Malgorzata, Clark, Christopher M., Aisen, Paul S., Petersen, Ronald C., Blennow, Kaj, Soares, Holly, Simon, Adam, Lewczuk, Piotr, Dean, Robert, Siemers, Eric, Potter, William, Lee, Virginia M.-Y., Trojanowski, John Q.

“…Objective Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects…”
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Therapeutic strategies for the treatment of tauopathies: Hopes and challenges by Khanna, Mansi R, Kovalevich, Jane, Lee, Virginia M.-Y, Trojanowski, John Q, Brunden, Kurt R

“…Abstract A group of neurodegenerative diseases referred to as tauopathies are characterized by the presence of brain cells harboring inclusions of pathological…”
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Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies by Peng, Chao, Gathagan, Ronald J., Lee, Virginia M.-Y.

“…The deposition of misfolded β-sheet enriched amyloid protein is a shared feature of many neurodegenerative diseases. Recent studies demonstrated the existence…”
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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology by Bassil, Fares, Brown, Hannah J., Pattabhiraman, Shankar, Iwasyk, Joe E., Maghames, Chantal M., Meymand, Emily S., Cox, Timothy O., Riddle, Dawn M., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.

“…Studies have shown an overlap of Aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of Alzheimer’s disease (AD) and Parkinson’s disease…”
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Deep clinical and neuropathological phenotyping of Pick disease by Irwin, David J., Brettschneider, Johannes, McMillan, Corey T., Cooper, Felicia, Olm, Christopher, Arnold, Steven E., Van Deerlin, Vivianna M., Seeley, William W., Miller, Bruce L., Lee, Edward B., Lee, Virginia M.-Y., Grossman, Murray, Trojanowski, John Q.

“…Objective To characterize sequential patterns of regional neuropathology and clinical symptoms in a well‐characterized cohort of 21 patients with…”
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Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections by Iba, Michiyo, McBride, Jennifer D., Guo, Jing L., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.

“…Filamentous tau inclusions are hallmarks of Alzheimer’s disease (AD) and other neurodegenerative tauopathies. An increasing number of studies implicate the…”
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Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo by Porta, Sílvia, Xu, Yan, Restrepo, Clark R., Kwong, Linda K., Zhang, Bin, Brown, Hannah J., Lee, Edward B., Trojanowski, John Q., Lee, Virginia M.-Y.

“…The stereotypical distribution of TAR DNA-binding 43 protein (TDP-43) aggregates in frontotemporal lobar degeneration (FTLD-TDP) suggests that pathological…”
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Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43 by Walker, Adam K., Spiller, Krista J., Ge, Guanghui, Zheng, Allen, Xu, Yan, Zhou, Melissa, Tripathy, Kalyan, Kwong, Linda K., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Accumulation of phosphorylated cytoplasmic TDP-43 inclusions accompanied by loss of normal nuclear TDP-43 in neurons and glia of the brain and spinal cord are…”
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Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells by Luk, Kelvin C, Song, Cheng, O'Brien, Patrick, Stieber, Anna, Branch, Jonathan R, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M.-Y

“…Cytoplasmic inclusions containing α-synuclein (α-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's…”
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Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia by Uemura, Maiko T, Maki, Takakuni, Ihara, Masafumi, Lee, Virginia M Y, Trojanowski, John Q

“…Pericytes are unique, multi-functional mural cells localized at the abluminal side of the perivascular space in microvessels. Originally discovered in 19th…”
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Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls by Maruyama, Masahiro, Shimada, Hitoshi, Suhara, Tetsuya, Shinotoh, Hitoshi, Ji, Bin, Maeda, Jun, Zhang, Ming-Rong, Trojanowski, John Q., Lee, Virginia M.-Y., Ono, Maiko, Masamoto, Kazuto, Takano, Harumasa, Sahara, Naruhiko, Iwata, Nobuhisa, Okamura, Nobuyuki, Furumoto, Shozo, Kudo, Yukitsuka, Chang, Qing, Saido, Takaomi C., Takashima, Akihiko, Lewis, Jada, Jang, Ming-Kuei, Aoki, Ichio, Ito, Hiroshi, Higuchi, Makoto

“…Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer’s disease (AD) and related…”
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