Search Results - "Virgil, Scott"

Asymmetric Synthesis of QUINAP via Dynamic Kinetic Resolution by Bhat, Vikram, Wang, Su, Stoltz, Brian M, Virgil, Scott C

“…A palladium-catalyzed, atroposelective C–P coupling process has been developed for the asymmetric synthesis of QUINAP and its derivatives in high enantiomeric…”
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Asymmetric Total Synthesis of Havellockate by Hafeman, Nicholas J., Chan, Melinda, Fulton, Tyler J., Alexy, Eric J., Loskot, Steven A., Virgil, Scott. C., Stoltz, Brian M.

“…The first total synthesis of the furanobutenolide-derived cembranoid diterpenoid havellockate is disclosed. Our convergent strategy employs a Julia–Kocienski…”
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Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters via Ir-Catalyzed Regio‑, Diastereo‑, and Enantioselective Allylic Alkylation and Applications in Sequential Pd Catalysis by Liu, Wen-Bo, Reeves, Corey M, Virgil, Scott C, Stoltz, Brian M

“…Highly congested vicinal stereocenters comprised of tertiary and all-carbon quaternary centers were generated via Ir-catalyzed asymmetric allylic alkylation of…”
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Cyclic Alkyl Amino Carbene (CAAC) Ruthenium Complexes as Remarkably Active Catalysts for Ethenolysis by Marx, Vanessa M., Sullivan, Alexandra H., Melaimi, Mohand, Virgil, Scott C., Keitz, Benjamin K., Weinberger, David S., Bertrand, Guy, Grubbs, Robert H.

“…An expanded family of ruthenium‐based metathesis catalysts bearing cyclic alkyl amino carbene (CAAC) ligands was prepared. These catalysts exhibited…”
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Highly Active Platinum Catalysts for Nitrile and Cyanohydrin Hydration: Catalyst Design and Ligand Screening via High-Throughput Techniques by Xing, Xiangyou, Xu, Chen, Chen, Bo, Li, Chengcheng, Virgil, Scott C, Grubbs, Robert H

“…Nitrile hydration provides access to amides that are indispensable to researchers in chemical and pharmaceutical industries. Prohibiting the use of this…”
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Total Synthesis of Hypersampsone M by Samkian, Adrian E., Virgil, Scott C., Stoltz, Brian M.

“…We report the first total synthesis of hypersampsone M, an archetypal member of the homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs)…”
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Catalytic Enantioselective Stereoablative Alkylation of 3-Halooxindoles: Facile Access to Oxindoles with C3 All-Carbon Quaternary Stereocenters by Ma, Sandy, Han, Xiaoqing, Krishnan, Shyam, Virgil, Scott C, Stoltz, Brian M

“…From 2 to 1! Racemic tertiary halooxindoles proceed to enantioenriched oxindoles bearing all‐carbon quaternary stereocenters as a result of a catalytic…”
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Synthesis and Activity of Six-Membered Cyclic Alkyl Amino Carbene–Ruthenium Olefin Metathesis Catalysts by Samkian, Adrian E, Xu, Yan, Virgil, Scott C, Yoon, Ki-Young, Grubbs, Robert H

“…Ru–cyclic alkyl amino carbene (Ru–CAAC) olefin metathesis catalysts perform extraordinarily in metathesis macrocyclization and ethenolysis, but previous…”
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A Convergent Total Synthesis of (+)-Ineleganolide by Gross, Benjamin M., Han, Seo-Jung, Virgil, Scott C., Stoltz, Brian M.

“…We report the total synthesis of the furanobutenolide-derived diterpenoid (+)-ineleganolide. The synthetic approach relies on a convergent strategy based on…”
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Total Synthesis of Aleutianamine by Yu, Hao, Sercel, Zachary P, Rezgui, Samir P, Farhi, Jonathan, Virgil, Scott C, Stoltz, Brian M

“…Aleutianamine is a recently isolated pyrroloiminoquinone natural product that displays potent and selective biological activity toward human pancreatic cancer…”
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Stereospecific Enzymatic Conversion of Boronic Acids to Amines by Hanley, Deirdre, Li, Zi-Qi, Gao, Shilong, Virgil, Scott C., Arnold, Frances H., Alfonzo, Edwin

“…Boronic acids and esters are highly regarded for their safety, unique reactivity, and versatility in synthesizing a wide range of small molecules,…”
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Enantioselective Nickel-Catalyzed α‑Spirocyclization of Lactones by Stanko, Allison M., Ramirez, Melissa, de Almenara, Adrian J., Virgil, Scott C., Stoltz, Brian M.

“…Herein we report a strategy for the enantioselective synthesis of spirocycles containing all-carbon quaternary centers via nickel-catalyzed intramolecular…”
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Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis by Welin, Eric R, Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M, McDermott, Martina S J, Conklin, Dylan, Gilmore, Christopher D, Tadross, Pamela M, Haley, Christopher K, Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U, Allan, Kevin M, Virgil, Scott C, Slamon, Dennis J, Stoltz, Brian M

“…The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer…”
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Divergent total syntheses of pyrroloiminoquinone alkaloids enabled by the development of a Larock/Buchwald-Hartwig annulation/cyclization by Rezgui, Samir P, Farhi, Jonathan, Yu, Hao, Sercel, Zachary P, Virgil, Scott C, Stoltz, Brian M

“…Pyrroloiminoquinone alkaloids are a large class of natural products that display a wide range of biological activities. Synthetic approaches to these natural…”
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The Total Synthesis of (−)-Scabrolide A by Hafeman, Nicholas J, Loskot, Steven A, Reimann, Christopher E, Pritchett, Beau P, Virgil, Scott C, Stoltz, Brian M

“…The first total synthesis of the norcembranoid diterpenoid scabrolide A is disclosed. The route begins with the synthesis of two chiral pool-derived fragments,…”
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Potassium tert-Butoxide-Catalyzed Dehydrogenative C–H Silylation of Heteroaromatics: A Combined Experimental and Computational Mechanistic Study by Liu, Wen-Bo, Schuman, David P, Yang, Yun-Fang, Toutov, Anton A, Liang, Yong, Klare, Hendrik F. T, Nesnas, Nasri, Oestreich, Martin, Blackmond, Donna G, Virgil, Scott C, Banerjee, Shibdas, Zare, Richard N, Grubbs, Robert H, Houk, K. N, Stoltz, Brian M

“…We recently reported a new method for the direct dehydrogenative C–H silylation of hetero­aromatics utilizing Earth-abundant potassium tert-butoxide. Herein we…”
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Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams by Behenna, Douglas C., Liu, Yiyang, Yurino, Taiga, Kim, Jimin, White, David E., Virgil, Scott C., Stoltz, Brian M.

“…The enantioselective synthesis of nitrogen-containing heterocycles ( N -heterocycles) represents a substantial chemical research effort and resonates across…”
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Nickel-catalyzed enantioselective allylic alkylation of lactones and lactams with unactivated allylic alcohols by Ngamnithiporn, Aurapat, Jette, Carina I, Bachman, Shoshana, Virgil, Scott C, Stoltz, Brian M

“…The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver products bearing an all-carbon quaternary…”
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Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (−)-Aspewentins A, B, and C by Liu, Yiyang, Virgil, Scott C., Grubbs, Robert H., Stoltz, Brian M.

“…The direct α‐vinylation of carbonyl compounds to form a quaternary stereocenter is a challenging transformation. It was discovered that δ‐oxocarboxylic acids…”
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Total Synthesis of Strempeliopidine and Non-Natural Stereoisomers through a Convergent Petasis Borono–Mannich Reaction by Rand, Alexander W., Gonzalez, Kevin J., Reimann, Christopher E., Virgil, Scott C., Stoltz, Brian M.

“…Strempeliopidine is a member of the monoterpenoid bisindole alkaloid family, a class of natural products that have been shown to elicit an array of biological…”
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