Search Results - "Viranga Tillekeratne, L M"

Cofilin Inhibitor Improves Neurological and Cognitive Functions after Intracerebral Hemorrhage by Suppressing Endoplasmic Reticulum Stress Related-Neuroinflammation by Almarghalani, Daniyah A, Bahader, Ghaith A, Ali, Mohammad, Tillekeratne, L M Viranga, Shah, Zahoor A

“…Neuroinflammation after intracerebral hemorrhage (ICH) is a crucial factor that determines the extent of the injury. Cofilin is a cytoskeleton-associated…”
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Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F by Kuganesan, Nishanth, Dlamini, Samkeliso, Tillekeratne, L. M. Viranga, Taylor, William R.

“…p53 is a well-established critical cell cycle regulator. By inducing transcription of the gene encoding p21, p53 inhibits cyclin-dependent kinase…”
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Photoaffinity labeling and bioorthogonal ligation: Two critical tools for designing “Fish Hooks” to scout for target proteins by Karaj, Endri, Sindi, Shaimaa H., Viranga Tillekeratne, L.M.

“…[Display omitted] Small molecules remain an important category of therapeutic agents. Their binding to different proteins can lead to both desired and…”
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Identification and initial characterization of a potent inhibitor of ferroptosis by Kuganesan, Nishanth, Dlamini, Samkeliso, McDaniel, Jade, Tillekeratne, Viranga L. M., Taylor, William R.

“…Ferroptosis is a form of iron‐dependent cell death characterized by elevated lipid peroxides and reactive oxygen species (ROS). Glutathione (GSH) plays an…”
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Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells by Taylor, William R., Fedorka, Sara R., Gad, Ibtissam, Shah, Ronit, Alqahtani, Hanan D., Koranne, Radhika, Kuganesan, Nishanth, Dlamini, Samkeliso, Rogers, Tim, Al-Hamashi, Ayad, Kholodovych, Veronika, Barudi, Yusuf, Junk, Damian, Rashid, Maisha S., Jackson, Mark W., Tillekeratne, L. M. Viranga

“…Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the…”
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Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones by Riddhidev, Banerjee, Endri, Karaj, Sabitri, Lamichhane, Kotsull, Lauren, N., Nishanth, Kuganesan, Dragan, Isailovic, Mary Kay H, Pflum, James, Slama, William, Taylor, L. M. Viranga, Tillekeratne

“…Epigenetic regulation of gene expression using histone deacetylase (HDAC) inhibitors is a promising strategy for developing new anticancer agents. The most…”
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Mutant p53 reactivators protect breast cancer cells from ferroptosis by Rathnayake, Dewmi Sandaru, Dlamini, Samkeliso, Elkalawozgy, Kadry, Tillekeratne, L. M. Viranga, Taylor, William R.

“…Ferroptosis is a novel nonapoptotic form of cell death characterized by iron‐dependent reactive oxygen species‐mediated lipid peroxidation. In several…”
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Electrochemical detection of acetylcholine and choline: application to the quantitative nonradiochemical evaluation of choline transport by Barkhimer, Tatyana V, Kirchhoff, Jon R, Hudson, Richard A, Messer Jr, William S, Viranga Tillekeratne, L. M

“…The development of analytical methods for determining the cholinergic biomarkers acetylcholine (ACh) and choline (Ch) is important for assessing their role in…”
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Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics by Karaj, Endri, Dlamini, Samkeliso, Koranne, Radhika, Sindi, Shaimaa H., Perera, Lalith, Taylor, William R., Viranga Tillekeratne, L.M.

“…[Display omitted] •Structure-activity relationship of imidazole chalcone mimics.•Cytotoxic with IC50 values in the upper nanomolar to low micromolar…”
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Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue by Almaliti, Jehad, Al-Hamashi, Ayad A, Negmeldin, Ahmed T, Hanigan, Christin L, Perera, Lalith, Pflum, Mary Kay H, Casero, Robert A, Tillekeratne, L. M. Viranga

“…A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were…”
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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics by Al-Hamashi, Ayad A., Koranne, Radhika, Dlamini, Samkeliso, Alqahtani, Abdulateef, Karaj, Endri, Rashid, Maisha S., Knoff, Joseph R., Dunworth, Matthew, Pflum, Mary Kay H., Casero, Robert A., Perera, Lalith, Taylor, William R., Tillekeratne, L.M. Viranga

“…[Display omitted] •Synthesis of chalcone mimics containing an imidazole-based metal-binding group intended for HDAC inhibition.•Compounds showed cytotoxicity…”
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Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts by Ahmed, Salahuddin, Riegsecker, Sharayah, Beamer, Maria, Rahman, Ayesha, Bellini, Joseph V., Bhansali, Pravin, Tillekeratne, L.M. Viranga

“…In the present study, we evaluated the effect of largazole (LAR), a marine-derived class I HDAC inhibitor, on tumor necrosis factor-α (TNF-α)-induced…”
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Electrochemical and Electrocatalytic Properties of Imidazole Analogues of the Redox Cofactor Pyrroloquinoline Quinone by Lumibao, Claudine Y., Tillekeratne, L. M. Viranga, Kirchhoff, Jon R., Fouchard, David M. D., Hudson, Richard A.

“…The electrochemical and electrocatalytic properties of two synthetic imidazole analogues of the redox cofactor pyrroloquinoline quinone (PQQ) were evaluated…”
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Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner by Fedorka, Sara R, So, Kevin, Al-Hamashi, Ayad A, Gad, Ibtissam, Shah, Ronit, Kholodovych, Veronika, Alqahtani, Hanan D, Taylor, William R, Tillekeratne, L M Viranga

“…In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin…”
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Potential SARS-CoV-2 main protease inhibitors by Banerjee, Riddhidev, Perera, Lalith, Tillekeratne, L.M. Viranga

“…[Display omitted] •The SARS-CoV-2 main protease is a prime drug target.•Coronavirus main proteases share a structurally conserved substrate-binding region.•The…”
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Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups by Bhansali, Pravin, Hanigan, Christin L., Perera, Lalith, Casero, Robert A., Tillekeratne, L.M. Viranga

“…Several largazole analogues with modified surface recognition cap groups were synthesized and their HDAC inhibitory activities were determined. The C7-epimer…”
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Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents by Cai, Shuang, Mukherjee, Jhindan, Tillekeratne, L.M. Viranga, Hudson, Richard A., Kirchhoff, Jon R.

“…Two symmetrical bis-catechol substituted hexamethonium and decamethonium analogues were found to inhibit high-affinity choline transport in mouse brain…”
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Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis by Karaj, Endri, Sindi, Shaimaa H., Kuganesan, Nishanth, Perera, Lalith, Taylor, William, Tillekeratne, L. M. Viranga

“…Once considered potential liabilities, the modern era witnesses a renaissance of interest in covalent inhibitors in drug discovery. The available toolbox of…”
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Synthesis and characterization of luminescent cadmium selenide/zinc selenide/zinc sulfide cholinomimetic quantum dots by Gégout, Claire, McAtee, Maria L, Bennett, Nichole M, Viranga Tillekeratne, L M, Kirchhoff, Jon R

“…Luminescent quantum dots conjugated with highly selective molecular recognition ligands are widely used for targeting and imaging biological structures. In…”
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In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications by Wendland, Tom R., Muntean, Brian S., Kaur, Jaskiran, Mukherjee, Jhindan, Chen, Jie, Tan, Xinxuan, Attygalle, Dinesh, Collins, Robert W., Kirchhoff , Jon R., Tillekeratne , L. M. Viranga

“…Thiolated o‐quinone‐capped electrocatalysts modeled on the naturally occurring o‐quinone cofactor pyrroloquinoline quinone (PQQ) were designed and synthesized…”
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