Search Results - "Vionnet, Christine"
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ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy
Published in Cell reports (Cambridge) (28-09-2021)“…The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis. To better…”
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mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1
Published in Nature communications (10-08-2022)“…The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and proliferation, supporting anabolic reactions and…”
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A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts
Published in International journal of molecular sciences (20-06-2022)“…Wound healing pathologies are an increasing problem in ageing societies. Chronic, non-healing wounds, which cause high morbidity and severely reduce the…”
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Topology of 1-Acyl-sn-glycerol-3-phosphate Acyltransferases SLC1 and ALE1 and Related Membrane-bound O-Acyltransferases (MBOATs) of Saccharomyces cerevisiae
Published in The Journal of biological chemistry (21-10-2011)“…In yeast, phosphatidic acid, the biosynthetic precursor for all glycerophospholipids and triacylglycerols, is made de novo by the…”
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A novel pathway of ceramide metabolism in Saccharomyces cerevisiae
Published in Biochemical journal (01-10-2012)“…The hydrolysis of ceramides in yeast is catalysed by the alkaline ceramidases Ypc1p and Ydc1p, two highly homologous membrane proteins localized to the ER…”
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Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop
Published in PLoS genetics (01-07-2016)“…While most yeast enzymes for the biosynthesis of glycerophospholipids, sphingolipids and ergosterol are known, genes for several postulated transporters…”
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Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides
Published in Molecular microbiology (01-03-2009)“…All mature Saccharomyces cerevisiae sphingolipids comprise inositolphosphorylceramides containing C26:0 or C24:0 fatty acids and either phytosphingosine or…”
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Topology of the microsomal glycerol-3-phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae
Published in Molecular microbiology (01-12-2012)“…Summary All glycerophospholipids are made from phosphatidic acid, which, according to the traditional view, is generated at the cytosolic surface of the ER. In…”
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Ethanolaminephosphate Side Chain Added to Glycosylphosphatidylinositol (GPI) Anchor by Mcd4p Is Required for Ceramide Remodeling and Forward Transport of GPI Proteins from Endoplasmic Reticulum to Golgi
Published in The Journal of biological chemistry (21-07-2006)“…Glycosylphosphatidylinositol (GPI) anchors of mammals as well as yeast contain ethanolaminephosphate side chains on the α1–4- and the α1–6-linked mannoses of…”
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Human Homologues of LAG1 Reconstitute Acyl-CoA-dependent Ceramide Synthesis in Yeast
Published in The Journal of biological chemistry (26-09-2003)“…Lag1p and Lac1p are two highly homologous membrane proteins of the endoplasmic reticulum. lag1Δ lac1Δ double mutants in Saccharomyces cerevisiae lack an…”
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Incorporation of Ceramides into Saccharomyces cerevisiae Glycosylphosphatidylinositol-Anchored Proteins Can Be Monitored In Vitro
Published in Eukaryotic Cell (01-03-2009)“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Deletion of GPI7, a Yeast Gene Required for Addition of a Side Chain to the Glycosylphosphatidylinositol (GPI) Core Structure, Affects GPI Protein Transport, Remodeling, and Cell Wall Integrity
Published in The Journal of biological chemistry (21-05-1999)“…Gpi7 was isolated by screening for mutants defective in the surface expression of glycosylphosphatidylinositol (GPI) proteins. Gpi7 mutants are deficient in…”
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The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
Published in Cell reports (Cambridge) (24-09-2024)“…Autophagy initiation is regulated by the ULK1 kinase complex. To gain insights into functions of the holo-complex, we generated a deep interactome by combining…”
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Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall
Published in Molecular biology of the cell (01-11-2014)“…Temperature-sensitive cdc1(ts) mutants are reported to stop the cell cycle upon a shift to 30°C in early G2, that is, as small budded cells having completed…”
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CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae
Published in Molecular microbiology (01-09-2007)“…After glycosylphosphatidylinositols (GPIs) are added to GPI proteins of Saccharomyces cerevisiae, the fatty acid in sn-2 of the diacylglycerol moiety can be…”
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Structural characterization of suppressor lipids by high-resolution mass spectrometry
Published in Rapid communications in mass spectrometry (30-10-2016)“…Rationale Suppressor lipids were originally identified in 1993 and reported to encompass six lipid classes that enable Saccharomyces cerevisiae to live without…”
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Yeast Cells Lacking All Known Ceramide Synthases Continue to Make Complex Sphingolipids and to Incorporate Ceramides into Glycosylphosphatidylinositol (GPI) Anchors
Published in The Journal of biological chemistry (25-02-2011)“…In yeast, the inositolphosphorylceramides mostly contain C26:0 fatty acids. Inositolphosphorylceramides were considered to be important for viability because…”
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Topology of the microsomal glycerol‐3‐phosphate acyltransferase Gpt2p / Gat1p of S accharomyces cerevisiae
Published in Molecular microbiology (01-12-2012)“…Summary All glycerophospholipids are made from phosphatidic acid, which, according to the traditional view, is generated at the cytosolic surface of the ER …”
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