Search Results - "Violeta JONUŠIENĖ"

Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells by Nemeikaitė-Čėnienė, Aušra, Misevičienė, Lina, Marozienė, Audronė, Jonušienė, Violeta, Čėnas, Narimantas

“…NADPH:thioredoxin reductase (TrxR) is considered a potential target for anticancer agents. Several nitroheterocyclic sulfones, such as Stattic and Tri-1,…”
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Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity by Nemeikaitė-Čėnienė, Aušra, Šarlauskas, Jonas, Jonušienė, Violeta, Marozienė, Audronė, Misevičienė, Lina, Yantsevich, Aliaksei V, Čėnas, Narimantas

“…Derivatives of tirapazamine and other heteroaromatic oxides (ArN→O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action is…”
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Aerobic Cytotoxicity of Aromatic N- Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1) by Nemeikaitė-Čėnienė, Aušra, Šarlauskas, Jonas, Misevičienė, Lina, Marozienė, Audronė, Jonušienė, Violeta, Lesanavičius, Mindaugas, Čėnas, Narimantas

“…Derivatives of tirapazamine and other heteroaromatic oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities, which are typically…”
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NOTCH1, NOTCH3, NOTCH4, and JAG2 protein levels in human endometrial cancer by Sasnauskienė, Aušra, Jonušienė, Violeta, Krikštaponienė, Aurelija, Butkytė, Stasė, Dabkevičienė, Daiva, Kanopienė, Daiva, Kazbarienė, Birutė, Didžiapetrienė, Janina

“…Notch signaling is a conserved developmental pathway, which plays an important role in the regulation of cell proliferation, differentiation and death…”
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Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer by Lachej, Nadežda, Jonušienė, Violeta, Mažeikė, Augustina, Sasnauskienė, Aušra, Dabkevičienė, Daiva, Šimienė, Julija, Sužiedėlis, Kęstutis, Didžiapetrienė, Janina

“…Endometrial cancer is the  sixth most frequent type of cancer among women worldwide. Type  I adenocarcinomas account for 80-85% of endometrial cancer cases and…”
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Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116 by Kukcinaviciute, Egle, Jonusiene, Violeta, Sasnauskiene, Ausra, Dabkeviciene, Daiva, Eidenaite, Eigile, Laurinavicius, Arvydas

“…5‐fluorouracil (5‐FU) and oxaliplatin (OxaPt) are the main chemotherapeutics for colorectal cancer (CRC). Chemotherapy response rates for advanced CRC remain…”
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Association between Notch signaling pathway and cancer by Lachej, Nadežda, Didžiapetrienė, Janina, Kazbarienė, Birutė, Kanopienė, Daiva, Jonušienė, Violeta

“…Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and…”
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Implementation of postgenomic technologies for cancer research. Institutional experience by Martina RUDGALVYTĖ, Diana STANČIŪTĖ, Kristina BIELSKIENĖ, Violeta JONUŠIENĖ, Vida KIRVELIENĖ, Kęstutis SUŽIEDĖLIS, Vydmantas ATKOČIUS, Konstantinas Povilas VALUCKAS

“…Advance in molecular biology and the new technologies for biomedical research are being rapidly introduced into the research of complex pathologies worldwide…”
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Damage targeted to the mitochondrial interior induces autophagy, cell cycle arrest and, only at high doses, apoptosis by Sasnauskiene, Ausra, Kadziauskas, Jurgis, Vezelyte, Neringa, Jonusiene, Violeta, Kirveliene, Vida

“…It is generally accepted that permeabilization of the outer mitochondrial membrane is a crucial event in the induction of apoptosis. In order to know how the…”
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Differential effects of 5‐fluorouracil and oxaliplatin on autophagy in chemoresistant colorectal cancer cells by Zitkute, Vilmante, Kukcinaviciute, Egle, Jonusiene, Violeta, Starkuviene, Vytaute, Sasnauskiene, Ausra

“…Macroautophagy (hereafter autophagy) is one of the adaptive pathways that contribute to cancer cell chemoresistance. Despite the fact that autophagy can both…”
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The role of p62 in cell death and survival of 5-fluorouracil and oxaliplatin-resistant colorectal cancer cells by Zitkute, Vilmante, Jasinevicius, Andrius, Vaitiekaite, Guoda, Kukcinaviciute, Egle, Aleksandraviciute, Bernadeta, Eidenaite, Eigile, Sudeikis, Lukas, Jonusiene, Violeta, Sasnauskiene, Ausra

“…The protein sequestosome 1 (p62/SQSTM1) is primarily known as a selective autophagy cargo receptor, but due to its multidomain structure, it also has roles in…”
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The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116 by Dabkeviciene, Daiva, Jonusiene, Violeta, Zitkute, Vilmante, Zalyte, Egle, Grigaitis, Pranas, Kirveliene, Vida, Sasnauskiene, Ausra

“…Colorectal cancer is one of the most common malignant diseases and is a leading cause of cancer mortality in the Western world. Primary or acquired resistance…”
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Exogenous interleukin-1α signaling negatively impacts acquired chemoresistance and alters cell adhesion molecule expression pattern in colorectal carcinoma cells HCT116 by Grigaitis, Pranas, Jonusiene, Violeta, Zitkute, Vilmante, Dapkunas, Justas, Dabkeviciene, Daiva, Sasnauskiene, Ausra

“…•Exogenous IL-1α-pretreated HCT116 cells are more sensitive to 5-fluorouracil (5-FU).•IL-1α-pretreatment also increases chemosensitivity of a 5-FU-resistant…”
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Apoptosis, autophagy and cell cycle arrest following photodamage to mitochondrial interior by Sasnauskiene, Ausra, Kadziauskas, Jurgis, Vezelyte, Neringa, Jonusiene, Violeta, Kirveliene, Vida

“…Cell death induced by oxidative insult targeted to mitochondrial interior of A431 cells was investigated. For stimulated production of ROS in the inner space…”
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Components of NOTCH Signaling for Uterine Cancer Patients’ Prognosis by Lachej, Nadezda, Dabkeviciene, Daiva, Simiene, Julija, Sabaliauskaite, Rasa, Jonusiene, Violeta, Brasiunas, Vytautas, Sasnauskiene, Ausra, Vaicekauskaite, Ieva, Brasiuniene, Birute, Kanopiene, Daiva, Suziedelis, Kestutis, Didziapetriene, Janina

“…New molecular biomarkers that could have an independent prognostic value in endometrial cancer are currently under investigation. Recently, it was suggested…”
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Down-regulated expression of Notch signaling molecules in human endometrial cancer by Jonusiene, Violeta, Sasnauskiene, Ausra, Lachej, Nadezda, Kanopiene, Daiva, Dabkeviciene, Daiva, Sasnauskiene, Sofija, Kazbariene, Birute, Didziapetriene, Janina

“…Notch signaling pathway is a highly conserved developmental pathway, which plays an important role in the regulation of cellular proliferation, differentiation…”
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Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells by Savickiene, Jurate, Treigyte, Grazina, Jonusiene, Violeta, Bruzaite, Renata, Borutinskaite, Veronika-Viktorija, Navakauskiene, Ruta

“…Aberrant DNA methylation is a critical epigenetic process involved in gene expression of tumor cells. Diverse DNA methyltransferase inhibitors are being…”
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The cloning and characterization of Tetrahymena pyriformis translation elongation factor 1b alpha and gamma subunits by Jonusiene, Violeta, Sasnauskiene, Sofija, Juodka, Benediktas

“…The multi-subunit eukaryotic translation elongation factor 1 (eEF1) consists of two functionally distinct parts: G-protein eEF1A and guanine nucleotide…”
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