Search Results - "Viola, Kirsten L"

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease by Yang, Yun, Tapias, Victor, Acosta, Diana, Xu, Hui, Chen, Huanlian, Bhawal, Ruchika, Anderson, Elizabeth T., Ivanova, Elena, Lin, Hening, Sagdullaev, Botir T., Chen, Jianer, Klein, William L., Viola, Kirsten L., Gandy, Sam, Haroutunian, Vahram, Beal, M. Flint, Eliezer, David, Zhang, Sheng, Gibson, Gary E.

“…Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits called plaques and tangles are neuropathological hallmarks of…”
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Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers by De Felice, Fernanda G, Vieira, Marcelo N.N, Bomfim, Theresa R, Decker, Helena, Velasco, Pauline T, Lambert, Mary P, Viola, Kirsten L, Zhao, Wei-Qin, Ferreira, Sergio T, Klein, William L

“…Synapse deterioration underlying severe memory loss in early Alzheimer's disease (AD) is thought to be caused by soluble amyloid beta (Aβ) oligomers…”
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Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease by Ding, Yu, Zhao, Jiahui, Zhang, Xunle, Wang, Shanshan, Viola, Kirsten L, Chow, Frances E, Zhang, Yang, Lippa, Carol, Klein, William L, Gong, Yuesong

“…β-Amyloid protein (Aβ) putatively plays a seminal role in synaptic loss in Alzheimer's disease (AD). While there is no consensus regarding the…”
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Alzheimer's Disease-Affected Brain: Presence of Oligomeric Aβ Ligands (ADDLs) Suggests a Molecular Basis for Reversible Memory Loss by Gong, Yuesong, Chang, Lei, Viola, Kirsten L., Lacor, Pascale N., Lambert, Mary P., Finch, Caleb E., Krafft, Grant A., Klein, William L.

“…A molecular basis for memory failure in Alzheimer's disease (AD) has been recently hypothesized, in which a significant role is attributed to small, soluble…”
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The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer's Disease by Viola, Kirsten L, Bicca, Maira A, Bebenek, Adrian M, Kranz, Daniel L, Nandwana, Vikas, Waters, Emily A, Haney, Chad R, Lee, Maxwell, Gupta, Abhay, Brahmbhatt, Zachary, Huang, Weijian, Chang, Ting-Tung, Peck, Anderson, Valdez, Clarissa, Dravid, Vinayak P, Klein, William L

“…Improvements have been made in the diagnosis of Alzheimer's disease (AD), manifesting mostly in the development of imaging methods that allow for the detection…”
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An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis by Bartley, Samuel C, Proctor, Madison T, Xia, Hongjie, Ho, Evelyn, Kang, Dong S, Schuster, Kristen, Bicca, Maíra A, Seckler, Henrique S, Viola, Kirsten L, Patrie, Steven M, Kelleher, Neil L, De Mello, Fernando G, Klein, William L

“…Human amyloid beta peptide (Aβ) is a brain catabolite that at nanomolar concentrations can form neurotoxic oligomers (AβOs), which are known to accumulate in…”
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Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis by Viola, Kirsten L., Klein, William L.

“…Protein aggregation is common to dozens of diseases including prionoses, diabetes, Parkinson’s and Alzheimer’s. Over the past 15 years, there has been a…”
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The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade by Cline, Erika N, Bicca, Maíra Assunção, Viola, Kirsten L, Klein, William L

“…The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain damage leading to Alzheimer's disease (AD) was instigated by…”
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Diet‐induced Alzheimer's‐like syndrome in the rabbit by Weiss, Craig, Bertolino, Nicola, Procissi, Daniele, Aleppo, Grazia, Smith, Quinn C., Viola, Kirsten L., Bartley, Samuel C., Klein, William L., Disterhoft, John F.

“…Introduction Although mouse models of Alzheimer's disease (AD) have increased our understanding of the molecular basis of the disease, none of those models…”
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Aβ oligomer induced cognitive impairment and evaluation of ACU193‐MNS‐based MRI in rabbit by Rozema, Nicholas B., Procissi, Daniele, Bertolino, Nicola, Viola, Kirsten L., Nandwana, Vikas, Abdul, Nafay, Pribus, Sophia, Dravid, Vinayak, Klein, William L., Disterhoft, John F., Weiss, Craig

“…Introduction Amyloid‐beta oligomers (AβOs) accumulate in Alzheimer's disease and may instigate neuronal pathology and cognitive impairment. We examined the…”
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Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease by Viola, Kirsten L., Sbarboro, James, Sureka, Ruchi, De, Mrinmoy, Bicca, Maíra A., Wang, Jane, Vasavada, Shaleen, Satpathy, Sreyesh, Wu, Summer, Joshi, Hrushikesh, Velasco, Pauline T., MacRenaris, Keith, Waters, E. Alex, Lu, Chang, Phan, Joseph, Lacor, Pascale, Prasad, Pottumarthi, Dravid, Vinayak P., Klein, William L.

“…One way to image the molecular pathology in Alzheimer's disease is by positron emission tomography using probes that target amyloid fibrils. However, these…”
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Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice by Rodriguez, Guadalupe, Eren, Mesut, Haupfear, Isabel, Viola, Kirsten L., Cline, Erika N., Miyata, Toshio, Klein, William L., Vaughan, Douglas E., Dong, Hongxin

“…Rationale Extracellular proteolytic activity plays an important role in memory formation and the preservation of cognitive function. Previous studies have…”
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Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers by Pitt, Jason, Wilcox, Kyle C, Tortelli, Vanessa, Diniz, Luan Pereira, Oliveira, Maira S, Dobbins, Cassandra, Yu, Xiao-Wen, Nandamuri, Sathwik, Gomes, Flávia C A, DiNunno, Nadia, Viola, Kirsten L, De Felice, Fernanda G, Ferreira, Sergio T, Klein, William L

“…Synaptopathy underlying memory deficits in Alzheimer's disease (AD) is increasingly thought to be instigated by toxic oligomers of the amyloid beta peptide…”
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Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer’s patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability by Kelly, Louise, Seifi, Mohsen, Ma, Ruolin, Mitchell, Scott J., Rudolph, Uwe, Viola, Kirsten L., Klein, William L., Lambert, Jeremy J., Swinny, Jerome D.

“…Aims Amyloid β‐oligomers (AβO) are potent modulators of Alzheimer's pathology, yet their impact on one of the earliest brain regions to exhibit signs of the…”
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Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer’s Disease by Kandi, Soumya, Cline, Erika N., Rivera, Brianna M., Viola, Kirsten L., Zhu, Jiuhe, Condello, Carlo, LeDuc, Richard D., Klein, William L., Kelleher, Neil L., Patrie, Steven M.

“…Numerous Aβ proteoforms, identified in the human brain, possess differential neurotoxic and aggregation propensities. These proteoforms contribute in unknown…”
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Monoclonal antibodies that target pathological assemblies of Aβ by Lambert, Mary P, Velasco, Pauline T, Chang, Lei, Viola, Kirsten L, Fernandez, Sara, Lacor, Pascale N, Khuon, Daliya, Gong, Yuesong, Bigio, Eileen H, Shaw, Pamela, De Felice, Fernanda G, Krafft, Grant A, Klein, William L

“…Amyloid beta (Aβ) immunotherapy for Alzheimer's disease has shown initial success in mouse models of Alzheimer's disease and in human patients. However,…”
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Synaptic targeting by Alzheimer's-related amyloid beta oligomers by Lacor, Pascale N, Buniel, Maria C, Chang, Lei, Fernandez, Sara J, Gong, Yuesong, Viola, Kirsten L, Lambert, Mary P, Velasco, Pauline T, Bigio, Eileen H, Finch, Caleb E, Krafft, Grant A, Klein, William L

“…The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form new memories. For many years, this dementia was attributed to…”
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Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease by Wakeman, Dustin R., Weed, Michael R., Perez, Sylvia E., Cline, Erika N., Viola, Kirsten L., Wilcox, Kyle C., Moddrelle, David S., Nisbett, Ernell Z., Kurian, Anish M., Bell, Amanda F., Pike, Ricaldo, Jacobson, Peer B., Klein, William L., Mufson, Elliott J., Lawrence, Matthew S., Elsworth, John D.

“…Aims An obstacle to developing new treatment strategies for Alzheimer's disease (AD) has been the inadequate translation of findings in current AD transgenic…”
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A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers by Sebollela, Adriano, Cline, Erika N., Popova, Izolda, Luo, Kevin, Sun, Xiaoxia, Ahn, Jay, Barcelos, Milena A., Bezerra, Vanessa N., Lyra e Silva, Natalia M., Patel, Jason, Pinheiro, Nathalia R., Qin, Lei A., Kamel, Josette M., Weng, Anthea, DiNunno, Nadia, Bebenek, Adrian M., Velasco, Pauline T., Viola, Kirsten L., Lacor, Pascale N., Ferreira, Sergio T., Klein, William L.

“…Brain accumulation of soluble oligomers of the amyloid‐β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease…”
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Self-Assembly of Aβ1 - 42 into Globular Neurotoxins by Chromy, Brett A, Nowak, Richard J, Lambert, Mary P, Viola, Kirsten L, Chang, Lei, Velasco, Pauline T, Jones, Bryan W, Fernandez, Sara J, Lacor, Pascale N, Horowitz, Peleg, Finch, Caleb E, Krafft, Grant A, Klein, William L

“…Amyloid β 1−42 (Aβ1 - 42) is a self-associating peptide that becomes neurotoxic upon aggregation. Toxicity originally was attributed to the presence of large,…”
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