Search Results - "Vinogradova, Lyubov"

Synthesis and Antibacterial Evaluation of Ciprofloxacin Congeners with Spirocyclic Amine Periphery by Lukin, Alexei, Komarova, Kristina, Vinogradova, Lyubov, Rogacheva, Elizaveta, Kraeva, Lyudmila, Krasavin, Mikhail

“…The synthesis of novel fluoroquinolones, congeners of ciprofloxacin, which was inspired by earlier work on spirocyclic ciprofloxacin, is described. An…”
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5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens by Rogacheva, Elizaveta, Kraeva, Lyudmila, Lukin, Alexey, Vinogradova, Lyubov, Komarova, Kristina, Chudinov, Mikhail, Gureev, Maxim, Chupakhin, Evgeny

“…A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing…”
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Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead by Lukin, Alexei, Komarova, Kristina, Vinogradova, Lyubov, Dogonadze, Marine, Vinogradova, Tatiana, Yablonsky, Piotr, Kazantsev, Alexander, Krasavin, Mikhail

“…A small set of twelve compounds of a nitrofuran carboxamide chemotype was elaborated from a readily available 2,6-diazaspiro[3.4]octane building block,…”
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Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity by Vinogradova, Lyubov, Lukin, Alexey, Komarova, Kristina, Zhuravlev, Maxim, Fadeev, Artem, Chudinov, Mikhail, Rogacheva, Elizaveta, Kraeva, Lyudmila, Gureev, Maxim, Porozov, Yuri, Dogonadze, Marine, Vinogradova, Tatiana

“…A series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc…”
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The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis by Komarova, Kristina, Vinogradova, Lyubov, Lukin, Alexey, Zhuravlev, Maxim, Deniskin, Dmitry, Chudinov, Mikhail, Gureev, Maxim, Dogonadze, Marine, Zabolotnykh, Natalia, Vinogradova, Tatiana, Lavrova, Anastasia, Yablonskiy, Petr

“…A series of 21 new 7'H-spiro[azetidine-3,5'-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed…”
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Discovery and In Vivo Efficacy of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 4-(2-Aminoethyl)-N-(3,5-dimethylphenyl)piperidine-1-carboxamide Hydrochloride (AP163) for the Treatment of Psychotic Disorders by Krasavin, Mikhail, Peshkov, Anatoly A., Lukin, Alexey, Komarova, Kristina, Vinogradova, Lyubov, Smirnova, Daria, Kanov, Evgeny V., Kuvarzin, Savelii R., Murtazina, Ramilya Z., Efimova, Evgeniya V., Gureev, Maxim, Onokhin, Kirill, Zakharov, Konstantin, Gainetdinov, Raul R.

“…Starting from a screening hit, a set of analogs was synthesized based on a 4-(2-aminoethyl)piperidine core not associated previously with trace…”
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The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof by Komarova, Kristina Yu, Lukin, Alexey Yu, Vinogradova, Lyubov V., Zhuravlev, Maxim E., Dogonadze, Marine Z., Vinogradova, Tatiana I., Gureev, Maxim A., Chudinov, Mikhail V., Dar’in, Dmitry V.

“…The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M . tu- berculosis containing…”
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Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines] by Lukin, Alexey, Vinogradova, Lyubov, Komarova, Kristina, Krasavin, Mikhail

“…[Display omitted] A novel spirocyclic scaffold of 7'H-spiro[azetidine-3,5'-furo[3,4-d]pyrimidine] chemotype was synthesized in N-Boc-protected form. However,…”
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Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation by Lukin, Alexey, Vinogradova, Lyubov, Komarova, Kristina, Kalinin, Stanislav, Krasavin, Mikhail

“…[Display omitted] A fundamentally novel type of molecular probes for the recognition by carbonic anhydrase zinc enzymes which constitute promising target…”
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Convenient, DBU-promoted anti-Markovnikov hydration of 2-methyl-1-(3-arylprop-2-yn-1-yl)-1H-imidazoles in wet NMP by Lukin, Alexei, Nichugovskaya, Anna, Vinogradova, Lyubov, Komarova, Kristina, Balalaie, Saeed, Dar'in, Dmitry, Krasavin, Mikhail

“…[Display omitted] During attempts to involve 5-methyl-2-phenyl-1-(3-phenyl-prop-2-yn-1-yl)-1H-imidazole in a base-promoted, allene-mediated cyclization of the…”
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Urea derivatives of spirocyclic piperidines endowed with antibacterial activity by Lukin, Alexei, Komarova, Kristina, Vinogradova, Lyubov, Rogacheva, Elizaveta, Kraeva, Lyudmila, Dogonadge, Marine, Vinogradova, Tatiana, Krasavin, Mikhail

“…[Display omitted] Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test…”
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Scaffold hopping in the oxadiazole antibiotic structure leads to more active compounds by Vinogradova, Lyubov V., Komarova, Kristina Yu, Chudinov, Mikhail V., Rogacheva, Elizaveta V., Kraeva, Lyudmila A., Lukin, Alexey Yu

“…[Display omitted] Isosteric replacement of the oxadiazole ring by amide bond in the structure of new non-β-lactam antibiotics led to compounds with higher…”
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A multifunctional additive for heavy concretes by Barannikov, Mikhail V., Polyakov, Igor’ V., Vinogradova, Lyubov’ A., Polyakov, Vyacheslav S.

“…Introduction. Faster construction and commissioning of industrial and civil facilities is a main factor affecting their operational characteristics at the…”
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