Search Results - "Vinkers, CH"

Representation and Outcomes of Individuals With Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials by Taipale, Heidi, Schneider-Thoma, Johannes, Pinzón-Espinosa, Justo, Radua, Joaquim, Efthimiou, Orestis, Vinkers, Christiaan H, Mittendorfer-Rutz, Ellenor, Cardoner, Narcís, Pintor, Luis, Tanskanen, Antti, Tomlinson, Anneka, Fusar-Poli, Paolo, Cipriani, Andrea, Vieta, Eduard, Leucht, Stefan, Tiihonen, Jari, Luykx, Jurjen J

“…Most evidence about efficacy and safety of antipsychotics in schizophrenia spectrum disorders relies on randomized clinical trials (RCTs). However, owing to…”
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HPA Axis Genes, and Their Interaction with Childhood Maltreatment, are Related to Cortisol Levels and Stress-Related Phenotypes by Gerritsen, Lotte, Milaneschi, Yuri, Vinkers, Christiaan H, van Hemert, Albert M, van Velzen, Laura, Schmaal, Lianne, Penninx, Brenda Wjh

“…Stress responses are controlled by the hypothalamus pituitary adrenal (HPA)-axis and maladaptive stress responses are associated with the onset and maintenance…”
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A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking by Higgins-Chen, Albert T, Thrush, Kyra L, Wang, Yunzhang, Minteer, Christopher J, Kuo, Pei-Lun, Wang, Meng, Niimi, Peter, Sturm, Gabriel, Lin, Jue, Moore, Ann Zenobia, Bandinelli, Stefania, Vinkers, Christiaan H, Vermetten, Eric, Rutten, Bart P F, Geuze, Elbert, Okhuijsen-Pfeifer, Cynthia, van der Horst, Marte Z, Schreiter, Stefanie, Gutwinski, Stefan, Luykx, Jurjen J, Picard, Martin, Ferrucci, Luigi, Crimmins, Eileen M, Boks, Marco P, Hägg, Sara, Hu-Seliger, Tina T, Levine, Morgan E

“…Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show technical…”
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Increased responses of the reward circuitry to positive task feedback following acute stress in healthy controls but not in siblings of schizophrenia patients by van Leeuwen, J.M.C., Vink, M., Joëls, M., Kahn, R.S., Hermans, E.J., Vinkers, C.H.

“…Acute stress is known to affect the way we process rewards. For example, during, or directly after stress, activity within key brain areas of the reward…”
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Discontinuation of psychotropic medication: a synthesis of evidence across medication classes by Vinkers, Christiaan H., Kupka, Ralph W., Penninx, Brenda W., Ruhé, Henricus G., van Gaalen, Jakob M., van Haaren, Paul C. F., Schellekens, Arnt F. A., Jauhar, Sameer, Ramos-Quiroga, Josep A., Vieta, Eduard, Tiihonen, Jari, Veldman, Stijn E., Veling, Wim, Vis, Roeland, de Wit, Laura E., Luykx, Jurjen J.

“…Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some point…”
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The STRESS-NL database: A resource for human acute stress studies across the Netherlands by Bonapersona, Born, FJ, Bakvis, P., Branje, S., Elzinga, B., Evers, AWM, van Eysden, M., Fernandez, G., Habets, PC, Hartman, CA, Hermans, EJ, Meeus, W., van Middendorp, H., Nelemans, S., Oei, NY, Oldehinkel, AJ, Roelofs, K., de Rooij, SR, Smeets, T., Tollenaar, MS, Joëls, M., Vinkers, CH

“…Stress initiates a cascade of (neuro)biological, physiological, and behavioral changes, allowing us to respond to a challenging environment. The human response…”
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Efficacy and effectiveness of antipsychotics in schizophrenia: network meta-analyses combining evidence from randomised controlled trials and real-world data by Efthimiou, Orestis, Taipale, Heidi, Radua, Joaquim, Schneider-Thoma, Johannes, Pinzón-Espinosa, Justo, Ortuño, Maria, Vinkers, Christiaan H, Mittendorfer-Rutz, Ellenor, Cardoner, Narcís, Tanskanen, Antti, Fusar-Poli, Paolo, Cipriani, Andrea, Vieta, Eduard, Leucht, Stefan, Tiihonen, Jari, Luykx, Jurjen J

“…There is debate about the generalisability of results from randomised clinical trials (RCTs) to real-world settings. Studying outcomes of treatments for…”
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Antipsychotic use is associated with a blunted cortisol stress response: A study in euthymic bipolar disorder patients and their unaffected siblings by Houtepen, L.C, Boks, M.P.M, Kahn, R.S, Joëls, M, Vinkers, C.H

“…Abstract There is ample evidence that the acute stress response is altered in schizophrenia and bipolar disorder. However, it is not clear whether such changes…”
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The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders by Olivier, Jocelien D A, Vinkers, Christiaan H, Olivier, Berend

“…There is ample evidence that genetic factors play an important role in anxiety disorders. In support, human genome-wide association studies have implicated…”
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Differences in sexual behaviour in male and female rodents: role of serotonin by Olivier, Berend, Chan, Johnny S W, Snoeren, Eelke M, Olivier, Jocelien D A, Veening, Jan G, Vinkers, Christiaan H, Waldinger, Marcel D, Oosting, Ronald S

“…Serotonin plays an important role in both male and female sexual behaviour. In general, reduction of 5-HT function facilitates, whereas enhancement inhibits…”
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Olfactory bulbectomy induces rapid and stable changes in basal and stress-induced locomotor activity, heart rate and body temperature responses in the home cage by Vinkers, C.H, Breuer, M.E, Westphal, K.G.C, Korte, S.M, Oosting, R.S, Olivier, B, Groenink, L

“…Abstract Background: Olfactory bulbectomy (OBX) in rats causes several behavioral and neurochemical changes. However, the extent and onset of physiological and…”
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Stress-induced hyperthermia is reduced by rapid-acting anxiolytic drugs independent of injection stress in rats by Vinkers, Christiaan H., de Jong, Noëlle M., Kalkman, Cor J., Westphal, Koen G.C., van Oorschot, Ruud, Olivier, Berend, Korte, S. Mechiel, Groenink, Lucianne

“…Stress-induced hyperthermia (SIH) is the transient rise in body temperature after encountering a stressor. The SIH response can be blocked by administration of…”
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Kv7 channel modulators reduce the stress-induced hyperthermia response and cause locomotor sedation in rats by Narain, Surnaina S., Mirza, Naheed R., Olivier, Berend, Vinkers, Christiaan H.

“…Kv7 channels (KCNQ) are potassium ion channels that are important in controlling neuronal excitability, which have been implicated in psychiatric disorders…”
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Role of dopamine D sub(1) and D sub(2) receptors in CRF-induced disruption of sensorimotor gating by Vinkers, CH, Risbrough, V B, Geyer, MA, Caldwell, S, Low, MJ, Hauger, R L

“…Corticotropin-releasing factor (CRF), a neuropeptide released during stress, has been reported to modulate startle behavior, including reducing the threshold…”
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Direct-to-consumer communication on prescription only medicines via the internet in the Netherlands, a pilot study. Opinion of the pharmaceutical industry, patient associations and support groups by Fabius, A Mariette, Cheung, Ka-Chun, Rijcken, Cristianne J F, Vinkers, Christiaan H, Talsma, Herre

“…Investigation of the current application of direct-to-consumer (DTC) communication on prescription only medicines via the Intemet in the Netherlands…”
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