Search Results - "Vinkenborg, Jan L"

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation by Wang, Jing, Luo, Cheng, Shan, Changliang, You, Qiancheng, Lu, Junyan, Elf, Shannon, Zhou, Yu, Wen, Yi, Vinkenborg, Jan L., Fan, Jun, Kang, Heebum, Lin, Ruiting, Han, Dali, Xie, Yuxin, Karpus, Jason, Chen, Shijie, Ouyang, Shisheng, Luan, Chihao, Zhang, Naixia, Ding, Hong, Merkx, Maarten, Liu, Hong, Chen, Jing, Jiang, Hualiang, He, Chuan

“…Copper is a transition metal that plays critical roles in many life processes. Controlling the cellular concentration and trafficking of copper offers a route…”
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Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis by Vinkenborg, Jan L, Nicolson, Tamara J, Bellomo, Elisa A, Koay, Melissa S, Rutter, Guy A, Merkx, Maarten

“…A series of genetically encoded fluorescent sensors for intracellular Zn 2+ with binding affinities spanning the picomolar and nanomolar ranges show that…”
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Dynamic imaging of cytosolic zinc in Arabidopsis roots combining FRET sensors and RootChip technology by Lanquar, Viviane, Grossmann, Guido, Vinkenborg, Jan L, Merkx, Maarten, Thomine, Sébastien, Frommer, Wolf B

“…Zinc plays a central role in all living cells as a cofactor for enzymes and as a structural element enabling the adequate folding of proteins. In eukaryotic…”
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MagFRET: the first genetically encoded fluorescent Mg2+ sensor by Lindenburg, Laurens H, Vinkenborg, Jan L, Oortwijn, Jorn, Aper, Stijn J A, Merkx, Maarten

“…Magnesium has important structural, catalytic and signaling roles in cells, yet few tools exist to image this metal ion in real time and at subcellular…”
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Rational design of FRET sensor proteins based on mutually exclusive domain interactions by Merkx, Maarten, Golynskiy, Misha V, Lindenburg, Laurens H, Vinkenborg, Jan L

“…Proteins that switch between distinct conformational states are ideal to monitor and control molecular processes within the complexity of biological systems…”
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Reengineering of a fluorescent zinc sensor protein yields the first genetically encoded cadmium probe by Vinkenborg, Jan L, van Duijnhoven, Sander M J, Merkx, Maarten

“…Introduction of a (Cys)(4) metal binding site at the dimerization interface of two fluorescent protein domains yields a chelating FRET sensor protein that…”
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Aptamers for allosteric regulation by Vinkenborg, Jan L, Karnowski, Nora, Famulok, Michael

“…Aptamers are useful for allosteric regulation because they are nucleic acid–based structures in which ligand binding induces conformational changes that may…”
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Enhanced Sensitivity of FRET-Based Protease Sensors by Redesign of the GFP Dimerization Interface by Vinkenborg, Jan L., Evers, Toon H., Reulen, Sanne W. A., Meijer, E. W., Merkx, Maarten

“…Close encounters. Sensor proteins based on fluorescence resonance energy transfer (FRET) often display a modest change in emission ratio upon activation. Here,…”
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Aptamer-Based Affinity Labeling of Proteins by Vinkenborg, Jan L., Mayer, Günter, Famulok, Michael

“…A most able label: Labeled aptamers (see picture) can be cross‐linked to their target structures in a light‐dependent and highly specific manner as a result of…”
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Engineering Protein Switches: Sensors, Regulators, and Spare Parts for Biology and Biotechnology by Golynskiy, Misha V, Koay, Melissa S, Vinkenborg, Jan L, Merkx, Maarten

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Fluorescent imaging of transition metal homeostasis using genetically encoded sensors by Vinkenborg, Jan L, Koay, Melissa S, Merkx, M

“…The ability to image the concentration of transition metals in living cells in real time is important for understanding transition metal (TM) homeostasis and…”
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Evanescent Field Biosensor Using Polymer Slab Waveguide-Based Cartridges for the Optical Detection of Nanoparticles by Teigell Beneitez, Nuria, Missinne, Jeroen, Visser, Emiel W. A., van IJzendoorn, Leo J., Prins, Menno W. J., Schleipen, Jean J. H. B., Vinkenborg, Jan L., Rietjens, Gerard, Verschuuren, Marc A., Krishnamoorthy, Ganeshram, Orsel, Joke G., Van Steenberge, Geert

“…We present a polymer optical waveguide integration technology for the detection of nanoparticles in an evanescent field (EF)-based biosensor. Polymer…”
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Aptamer-basierte Affinitätsmarkierung von Proteinen by Vinkenborg, Jan L., Mayer, Günter, Famulok, Michael

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Dynamic imaging of cytosolic zinc in A rabidopsis roots combining FRET sensors and RootChip technology by Lanquar, Viviane, Grossmann, Guido, Vinkenborg, Jan L., Merkx, Maarten, Thomine, Sébastien, Frommer, Wolf B.

“…Zinc plays a central role in all living cells as a cofactor for enzymes and as a structural element enabling the adequate folding of proteins. In eukaryotic…”
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MagFRET: The First Genetically Encoded Fluorescent Mg.sup.2+ Sensor by Lindenburg, Laurens H, Vinkenborg, Jan L, Oortwijn, Jorn, Aper, Stijn J. A, Merkx, Maarten

“…Magnesium has important structural, catalytic and signaling roles in cells, yet few tools exist to image this metal ion in real time and at subcellular…”
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Engineering Protein Switches: Sensors, Regulators, and Spare Parts for Biology and Biotechnology by Golynskiy, Misha V., Koay, Melissa S., Vinkenborg, Jan L., Merkx, Maarten

“…Switch protein switch! Proteins that switch between distinct conformational states are ideal for monitoring and controlling molecular processes in biological…”
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Aptamer‐basierte Affinitätsmarkierung von Proteinen by Vinkenborg, Jan L., Mayer, Günter, Famulok, Michael

“…Vielseitig anwendbar ist die Aptamer‐basierte Affinitätsmarkierung (ABAL) von Proteinen mit Aptameren. ABAL kann lichtabhängig zur hochspezifischen kovalenten…”
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Genetically encoded FRET sensors to monitor intracellular [Zn.sup.2+] homeostasis by Vinkenborg, Jan L, Nicolson, Tamara J, Koay, Melissa S, Rutter, Guy A, Merkx, Maarten

“…We developed genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon [Zn.sup.2+] binding,…”
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Genetically encoded FRET sensors to monitor intracellular Zn 2+ homeostasis by Rutter, Guy A, Merkx, Maarten, Vinkenborg, Jan L, Nicolson, Tamara J, Bellomo, Elisa A, Koay, Melissa S

“…We developed genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon Zn2+ binding, have…”
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Genetically encoded FRET sensors to monitor intracellular Zn super(2+) homeostasis by Vinkenborg, Jan L, Nicolson, Tamara J, Bellomo, Elisa A, Koay, Melissa S, Rutter, Guy A, Merkx, Maarten

“…We developed genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon Zn2+ binding, have…”
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