Search Results - "Vink, Chris S"

Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells by Chen, Michael J., Li, Yan, De Obaldia, Maria Elena, Yang, Qi, Yzaguirre, Amanda D., Yamada-Inagawa, Tomoko, Vink, Chris S., Bhandoola, Avinash, Dzierzak, Elaine, Speck, Nancy A.

“…Hematopoietic stem cells (HSCs) and an earlier wave of definitive erythroid/myeloid progenitors (EMPs) differentiate from hemogenic endothelial cells in the…”
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Gata2 is required for HSC generation and survival by de Pater, Emma, Kaimakis, Polynikis, Vink, Chris S, Yokomizo, Tomomasa, Yamada-Inagawa, Tomoko, van der Linden, Reinier, Kartalaei, Parham Solaimani, Camper, Sally A, Speck, Nancy, Dzierzak, Elaine

“…Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC) generation is of particular importance for current hematopoietic…”
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Hematopoietic (stem) cell development — how divergent are the roads taken? by Kauts, Mari‐Liis, Vink, Chris S., Dzierzak, Elaine

“…The development of the hematopoietic system during early embryonic stages occurs in spatially and temporally distinct waves. Hematopoietic stem cells (HSC),…”
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Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation by Solaimani Kartalaei, Parham, Yamada-Inagawa, Tomoko, Vink, Chris S, de Pater, Emma, van der Linden, Reinier, Marks-Bluth, Jonathon, van der Sloot, Anthon, van den Hout, Mirjam, Yokomizo, Tomomasa, van Schaick-Solernó, M Lucila, Delwel, Ruud, Pimanda, John E, van IJcken, Wilfred F J, Dzierzak, Elaine

“…Hematopoietic stem cells (HSCs) are generated via a natural transdifferentiation process known as endothelial to hematopoietic cell transition (EHT). Because…”
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Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development by Munro, David AD, Wineberg, Yishay, Tarnick, Julia, Vink, Chris S, Li, Zhuan, Pridans, Clare, Dzierzak, Elaine, Kalisky, Tomer, Hohenstein, Peter, Davies, Jamie A

“…The origins and functions of kidney macrophages in the adult have been explored, but their roles during development remain largely unknown. Here we…”
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In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate by Eich, Christina, Arlt, Jochen, Vink, Chris S, Solaimani Kartalaei, Parham, Kaimakis, Polynikis, Mariani, Samanta A, van der Linden, Reinier, van Cappellen, Wiggert A, Dzierzak, Elaine

“…Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play…”
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Embryonic Origins of the Hematopoietic System: Hierarchies and Heterogeneity by Vink, Chris S., Mariani, Samanta A., Dzierzak, Elaine

“…The hierarchical framework of the adult blood system as we know it from current medical and hematology textbooks, displays a linear branching network of…”
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Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors by Kaimakis, Polynikis, de Pater, Emma, Eich, Christina, Solaimani Kartalaei, Parham, Kauts, Mari-Liis, Vink, Chris S., van der Linden, Reinier, Jaegle, Martine, Yokomizo, Tomomasa, Meijer, Dies, Dzierzak, Elaine

“…The Gata2 transcription factor is a pivotal regulator of hematopoietic cell development and maintenance, highlighted by the fact that Gata2 haploinsufficiency…”
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De novo hematopoietic (stem) cell generation — A differentiation or stochastic process? by Vink, Chris S., Popravko, Anna, Dzierzak, Elaine

“…The hematopoietic system is one of the earliest tissues to develop. De novo generation of hematopoietic progenitor and stem cells occurs through a…”
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The (intra-aortic) hematopoietic cluster cocktail: what is in the mix? by Vink, Chris S., Dzierzak, Elaine

“…•Marker combinations identify hematopoietic cells emerging from the embryonic aorta•IAHC cells are phenotypically, transcriptionally, and functionally…”
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BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo by Crisan, Mihaela, Solaimani Kartalaei, Parham, Neagu, Alex, Karkanpouna, Sofia, Yamada-Inagawa, Tomoko, Purini, Caterina, Vink, Chris S., van der Linden, Reinier, van Ijcken, Wilfred, Chuva de Sousa Lopes, Susana M., Monteiro, Rui, Mummery, Christine, Dzierzak, Elaine

“…Hematopoietic stem cells (HSC), the self-renewing cells of the adult blood differentiation hierarchy, are generated during embryonic stages. The first HSCs are…”
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Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head by Li, Zhuan, Vink, Chris S., Mariani, Samanta A., Dzierzak, Elaine

“…Hematopoietic cell generation in the midgestation mouse embryo occurs through the natural transdifferentiation of temporally and spatially restricted set of…”
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CNS macrophages differentially rely on an intronic Csf1r enhancer for their development by Munro, David A D, Bradford, Barry M, Mariani, Samanta A, Hampton, David W, Vink, Chris S, Chandran, Siddharthan, Hume, David A, Pridans, Clare, Priller, Josef

“…The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, collectively termed border-associated…”
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Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation by Porcheri, Cristina, Golan, Ohad, Calero‐Nieto, Fernando J, Thambyrajah, Roshana, Ruiz‐Herguido, Cristina, Wang, Xiaonan, Catto, Francesca, Guillén, Yolanda, Sinha, Roshani, González, Jessica, Kinston, Sarah J, Mariani, Samanta A, Maglitto, Antonio, Vink, Chris S, Dzierzak, Elaine, Charbord, Pierre, Göttgens, Bertie, Espinosa, Lluis, Sprinzak, David, Bigas, Anna

“…Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is…”
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A role for macrophages in hematopoiesis in the embryonic head by Li, Zhuan, Mariani, Samanta A., Rodriguez-Seoane, Carmen, He, Wenyan, Ning, Xiaowei, Liu, Bing, Vink, Chris S., Dzierzak, Elaine

“…Along with the aorta-gonad-mesonephros region, the head is a site of hematopoietic stem and progenitor cell (HS/PC) development in the mouse embryo…”
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BMP signalling differentially regulates distinct haematopoietic stem cell types by Crisan, Mihaela, Kartalaei, Parham Solaimani, Vink, Chris S., Yamada-Inagawa, Tomoko, Bollerot, Karine, van IJcken, Wilfred, van der Linden, Reinier, de Sousa Lopes, Susana M. Chuva, Monteiro, Rui, Mummery, Christine, Dzierzak, Elaine

“…Adult haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewable repopulating ability, but with different…”
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Hematopoietic (stem) cell development—how divergent are the roads taken? by Kauts, Mari‐Liis, Vink, Chris S., Dzierzak, Elaine

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Localization and characterization of hematopoietic cells in the mouse embryonic head by Li, Zhuan, Vink, Chris S, Mariani, Samanta, Dzierzak, Elaine

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Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation by Maglitto, Antonio, Mariani, Samanta A., de Pater, Emma, Rodriguez-Seoane, Carmen, Vink, Chris S., Piao, Xianhua, Lukke, Mari-Liis, Dzierzak, Elaine

“…Integrated molecular signals regulate cell fate decisions in the embryonic aortic endothelium to drive hematopoietic stem cell (HSC) generation during…”
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Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes by Nasrallah, Rabab, Fast, Eva M., Solaimani, Parham, Knezevic, Kathy, Eliades, Alexia, Patel, Rahima, Thambyrajah, Roshana, Unnikrishnan, Ashwin, Thoms, Julie, Beck, Dominik, Vink, Chris S., Smith, Aileen, Wong, Jason, Shepherd, Mairi, Kent, David, Roychoudhuri, Rahul, Paul, Fabian, Klippert, Julia, Hammes, Annette, Willnow, Thomas, Göttgens, Bertie, Dzierzak, Elaine, Zon, Leonard I., Lacaud, George, Kouskoff, Valerie, Pimanda, John E.

“…Enhancers are the primary determinants of cell identity, and specific promoter/enhancer combinations of Endoglin (ENG) have been shown to target blood and…”
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