Search Results - "Vink, A. A."

Truncating Titin ( TTN) Variants in Chemotherapy-Induced Cardiomyopathy by Linschoten, M., BSc, Teske, A.J., MD, PhD, Baas, A.F., MD, PhD, Vink, A., MD, PhD, Dooijes, D., PhD, Baars, H.F., MD, Asselbergs, F.W., MD, PhD

“…Highlights • Truncating titin variants are found in chemotherapy-induced cardiomyopathy • Phenotypic expression after chemotherapy illustrates a second-hit…”
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The impact of lentiviral vector genome size and producer cell genomic to gag-pol mRNA ratios on packaging efficiency and titre by Sweeney, Nathan P., Vink, Conrad A.

“…Lentiviral vectors are showing success in the clinic, but producing enough vector to meet the growing demand is a major challenge. Furthermore, next-generation…”
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PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems by Vink, Jochem N A, Baijens, Jan H L, Brouns, Stan J J

“…The adaptive CRISPR-Cas immune system stores sequences from past invaders as spacers in CRISPR arrays and thereby provides direct evidence that links invaders…”
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Visualisation of dCas9 target search in vivo using an open-microscopy framework by Martens, Koen J. A., van Beljouw, Sam P. B., van der Els, Simon, Vink, Jochem N. A., Baas, Sander, Vogelaar, George A., Brouns, Stan J. J., van Baarlen, Peter, Kleerebezem, Michiel, Hohlbein, Johannes

“…CRISPR-Cas9 is widely used in genomic editing, but the kinetics of target search and its relation to the cellular concentration of Cas9 have remained elusive…”
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The effect of music therapy compared with general recreational activities in reducing agitation in people with dementia: a randomised controlled trial by Vink, A. C., Zuidersma, M., Boersma, F., de Jonge, P., Zuidema, S. U., Slaets, J. P. J.

“…Objective This study aimed to compare the effects of music therapy with general recreational day activities in reducing agitation in people with dementia,…”
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Manual vs. automatic assessment of the QT-interval and corrected QT by Neumann, Benjamin, Vink, A Suzanne, Hermans, Ben J M, Lieve, Krystien V V, Cömert, Didem, Beckmann, Britt-Maria, Clur, Sally-Ann B, Blom, Nico A, Delhaas, Tammo, Wilde, Arthur A M, Kääb, Stefan, Postema, Pieter G, Sinner, Moritz F

“…Abstract Aims Sudden cardiac death (SCD) is challenging to predict. Electrocardiogram (ECG)-derived heart rate-corrected QT-interval (QTc) is used for SCD-risk…”
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Clinical Progression of High-Grade Cervical Intraepithelial Neoplasia: Estimating the Time to Preclinical Cervical Cancer From Doubly Censored National Registry Data by VINK, Margaretha A, BOGAARDS, Johannes A, VAN KEMENADE, Folkert J, DE MELKER, Hester E, MEIJER, Chris J. L. M, BERKHOF, Johannes

“…Little is known about the time span of progression from high-grade cervical intraepithelial neoplasia (CIN2/3) to invasive cervical cancer. Estimation of this…”
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Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study by Vink, Eva E, Goldschmeding, Roel, Vink, Aryan, Weggemans, Callista, Bleijs, Ronald L A W, Blankestijn, Peter J

“…Renal denervation (RDN) is a promising novel treatment for resistant hypertension. Effectiveness of treatment is, however, highly variable and unpredictable…”
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Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs by Vink, Henk A., Ramekers, Dyan, Thomeer, Hans G. X. M., Versnel, Huib

“…Severe hearing loss or deafness is often caused by cochlear hair cell loss and can be mitigated by a cochlear implant (CI). CIs target the auditory nerve,…”
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HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency by Sertkaya, Helin, Ficarelli, Mattia, Sweeney, Nathan P., Parker, Hannah, Vink, Conrad A., Swanson, Chad M.

“…Many lentiviral vectors used for gene therapy are derived from HIV-1. An optimal vector genome would include only the viral sequences required for transduction…”
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Efficient CRISPR-Cas13d-Based Antiviral Strategy to Combat SARS-CoV-2 by Hussein, Mouraya, Andrade Dos Ramos, Zaria, Vink, Monique A, Kroon, Pascal, Yu, Zhenghao, Enjuanes, Luis, Zuñiga, Sonia, Berkhout, Ben, Herrera-Carrillo, Elena

“…The current SARS-CoV-2 pandemic forms a major global health burden. Although protective vaccines are available, concerns remain as new virus variants continue…”
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Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study by Groen, M. H. A, Slieker, F. J. B, Vink, A., de Borst, G. J., Simons, M. V., Ebbini, E. S., Doevendans, P. A., Hazenberg, C. E. V. B., van Es, R.

“…High-intensity focused ultrasound (HIFU) is a potential noninvasive thermal ablation method for the treatment of peripheral artery disease. Dual-mode…”
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Music therapy for people with dementia by Vink, A C, Birks, J S, Bruinsma, M S, Scholten, R J S

“…Dementia is a clinical syndrome with a number of different causes which is characterised by deterioration in cognitive functions. Research is pursuing a…”
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Single cell variability of CRISPR‐Cas interference and adaptation by McKenzie, Rebecca E, Keizer, Emma M, Vink, Jochem N A, van Lopik, Jasper, Büke, Ferhat, Kalkman, Vera, Fleck, Christian, Tans, Sander J, Brouns, Stan J J

“…While CRISPR‐Cas defence mechanisms have been studied on a population level, their temporal dynamics and variability in individual cells have remained unknown…”
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Using CAPTURE to detect spacer acquisition in native CRISPR arrays by McKenzie, Rebecca E., Almendros, Cristóbal, Vink, Jochem N. A., Brouns, Stan J. J.

“…CRISPR–Cas systems are able to acquire immunological memories (spacers) from bacteriophages and plasmids in order to survive infection; however, this often…”
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Imaging the intracranial atherosclerotic vessel wall using 7T MRI: initial comparison with histopathology by van der Kolk, A G, Zwanenburg, J J M, Denswil, N P, Vink, A, Spliet, W G M, Daemen, M J A P, Visser, F, Klomp, D W J, Luijten, P R, Hendrikse, J

“…Several studies have attempted to characterize intracranial atherosclerotic plaques by using MR imaging sequences. However, dedicated validation of these…”
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Growth patterns and cerebroplacental hemodynamics in fetuses with congenital heart disease by Mebius, M. J., Clur, S. A. B., Vink, A. S., Pajkrt, E., Kalteren, W. S., Kooi, E. M. W., Bos, A. F., du Marchie Sarvaas, G. J., Bilardo, C. M.

“…ABSTRACT Objectives Congenital heart disease (CHD) has been associated with reduced fetal head circumference (HC), although the underlying pathophysiology…”
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The Potential of Stem Cell Therapy to Repair White Matter Injury in Preterm Infants: Lessons Learned From Experimental Models by Vaes, Josine E G, Vink, Marit A, de Theije, Caroline G M, Hoebeek, Freek E, Benders, Manon J N L, Nijboer, Cora H A

“…Diffuse white matter injury (dWMI) is a major cause of morbidity in the extremely preterm born infant leading to life-long neurological impairments, including…”
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The Prognostic Value of Biomarkers in Non-ST-Elevation Acute Coronary Syndrome Patients that are Treated by an Early Invasive Strategy: Insights from the OPTIMA-2 Trial by Fagel, Nick D, Vink, Maarten A, Heestermans, Antonius A C M, Riezebos, Robert K

“…Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) consists of a heterogenic population and improvement in identification of a specific risk…”
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Lentiviral vectors can be used for full-length dystrophin gene therapy by Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier

“…Duchenne Muscular Dystrophy (DMD) is caused by a lack of dystrophin expression in patient muscle fibres. Current DMD gene therapy strategies rely on the…”
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